3WZD
KDR in complex with ligand lenvatinib
Summary for 3WZD
Entry DOI | 10.2210/pdb3wzd/pdb |
Related | 3WZE |
Descriptor | Vascular endothelial growth factor receptor 2, 4-{3-chloro-4-[(cyclopropylcarbamoyl)amino]phenoxy}-7-methoxyquinoline-6-carboxamide, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... (7 entities in total) |
Functional Keywords | kdr receptor kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968 |
Total number of polymer chains | 1 |
Total formula weight | 36821.08 |
Authors | Okamoto, K.,Ikemori_Kawada, M.,Inoue, A.,Matsui, J. (deposition date: 2014-09-24, release date: 2015-05-27) |
Primary citation | Okamoto, K.,Ikemori-Kawada, M.,Jestel, A.,von Konig, K.,Funahashi, Y.,Matsushima, T.,Tsuruoka, A.,Inoue, A.,Matsui, J. Distinct binding mode of multikinase inhibitor lenvatinib revealed by biochemical characterization. ACS MED.CHEM.LETT., 6:89-94, 2015 Cited by PubMed: 25589937DOI: 10.1021/ml500394m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.57 Å) |
Structure validation
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