3WZD

KDR in complex with ligand lenvatinib

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE LEV A 1201

Chain	Residue
A	GLY841
A	GLY922
A	LEU1035
A	CYS1045
A	ASP1046
A	PHE1047
A	GOL1210
A	HOH3001
A	HOH3002
A	HOH3003
A	ALA866
A	GLU885
A	ILE888
A	VAL899
A	GLU917
A	PHE918
A	CYS919
A	LYS920

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DTT A 1202

Chain	Residue
A	CYS1024
A	ILE1025

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DTT A 1203

Chain	Residue
A	ASP852
A	CYS862
A	ARG863
A	THR864

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DTT A 1204

Chain	Residue
A	ILE1077
A	PHE1078
A	ASP1112
A	GLU1113
A	CYS1116

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DTT A 1205

Chain	Residue
A	CYS1007
A	LEU1164

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1206

Chain	Residue
A	PHE921
A	TYR927
A	SER930
A	HOH3014
A	HOH3029

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1207

Chain	Residue
A	ALA1020
A	ILE1084
A	GLN1085
A	THR1152
A	PHE1153
A	SER1154
A	HOH3090

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1208

Chain	Residue
A	TRP1096
A	SER1100
A	PRO1128
A	ASP1129
A	HOH3129
A	HOH3162

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1209

Chain	Residue
A	PHE921
A	SER1037
A	GLU1038
A	LYS1039
A	ASN1040
A	HOH3082

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1210

Chain	Residue
A	ARG1032
A	ASN1033
A	CYS1045
A	ASP1046
A	LEV1201
A	HOH3001
A	HOH3013

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1211

Chain	Residue
A	GLU1003
A	HIS1004
A	CYS1007
A	ASN1040

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	29
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGAFGQVIeAdafgidktatcrt.....VAVK

Chain	Residue	Details
A	LEU840-LYS868

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNILL

Chain	Residue	Details
A	CYS1024-LEU1036

---

site_id	PS00240
Number of Residues	14
Details	RECEPTOR_TYR_KIN_III Receptor tyrosine kinase class III signature. GhHlNVVNLLGACT

Chain	Residue	Details
A	GLY893-THR906

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"10102632","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18936167","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---