8J6P
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![BU of 8j6p by Molmil](/molmil-images/mine/8j6p) | Cryo-EM structure of the MK-6892-bound human HCAR2-Gi1 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide, CHOLESTEROL, ... | Authors: | Mao, C, Gao, M, Zang, S, Zhu, Y, Ma, X, Zhang, Y. | Deposit date: | 2023-04-26 | Release date: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (2.55 Å) | Cite: | Orthosteric and allosteric modulation of human HCAR2 signaling complex. Nat Commun, 14, 2023
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7DRT
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![BU of 7drt by Molmil](/molmil-images/mine/7drt) | Human Wntless in complex with Wnt3a | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhong, Q, Zhao, Y, Ye, F, Xiao, Z, Huang, G, Zhang, Y, Lu, P, Xu, W, Zhou, Q, Ma, D. | Deposit date: | 2020-12-29 | Release date: | 2021-07-14 | Last modified: | 2021-09-08 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Cryo-EM structure of human Wntless in complex with Wnt3a. Nat Commun, 12, 2021
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7VZF
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![BU of 7vzf by Molmil](/molmil-images/mine/7vzf) | Cryo-EM structure of amyloid fibril formed by full-length human SOD1 | Descriptor: | Superoxide dismutase [Cu-Zn] | Authors: | Wang, L.Q, Ma, Y.Y, Yuan, H.Y, Zhao, K, Zhang, M.Y, Wang, Q, Huang, X, Xu, W.C, Chen, J, Li, D, Zhang, D.L, Zou, L.Y, Yin, P, Liu, C, Liang, Y. | Deposit date: | 2021-11-16 | Release date: | 2022-06-29 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion. Nat Commun, 13, 2022
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4E4K
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![BU of 4e4k by Molmil](/molmil-images/mine/4e4k) | Crystal Structure of PPARgamma with the ligand JO21 | Descriptor: | (2S)-3-phenyl-2-{[2'-(propan-2-yl)biphenyl-4-yl]oxy}propanoic acid, Peroxisome proliferator-activated receptor gamma | Authors: | Pochetti, G, Montanari, R, Loiodice, F, Fracchiolla, G, Laghezza, A, Carbonara, G, Piemontese, L, Lavecchia, A, Novellino, E. | Deposit date: | 2012-03-13 | Release date: | 2013-01-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | New 2-(Aryloxy)-3-phenylpropanoic Acids as Peroxisome Proliferator-Activated Receptor alpha/gamma Dual Agonists Able To Upregulate Mitochondrial Carnitine Shuttle System Gene Expression. J.Med.Chem., 56, 2013
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4E4Q
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![BU of 4e4q by Molmil](/molmil-images/mine/4e4q) | Crystal structure of PPARgamma with the ligand FS214 | Descriptor: | (2R)-3-phenyl-2-{[2'-(propan-2-yl)biphenyl-4-yl]oxy}propanoic acid, Peroxisome proliferator-activated receptor gamma | Authors: | Pochetti, G, Montanari, R, Loiodice, F, Fracchiolla, G, Laghezza, A, Carbonara, G, Piemontese, L, Lavecchia, A, Novellino, E. | Deposit date: | 2012-03-13 | Release date: | 2013-01-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | New 2-(Aryloxy)-3-phenylpropanoic Acids as Peroxisome Proliferator-Activated Receptor alpha/gamma Dual Agonists Able To Upregulate Mitochondrial Carnitine Shuttle System Gene Expression. J.Med.Chem., 56, 2013
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7CYZ
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![BU of 7cyz by Molmil](/molmil-images/mine/7cyz) | The structure of human ORP3 OSBP-related domain | Descriptor: | Oxysterol-binding protein-related protein 3 | Authors: | Dong, X. | Deposit date: | 2020-09-05 | Release date: | 2020-10-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The crystal structure of ORP3 reveals the conservative PI4P binding pattern. Biochem.Biophys.Res.Commun., 529, 2020
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7DP8
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![BU of 7dp8 by Molmil](/molmil-images/mine/7dp8) | Crystal structure of T2R-TTL-Cevipabulin-eribulin complex | Descriptor: | (1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-20-[(2S)-3-amino-2-hydroxypropyl]-21-methoxy-14-methyl-8,15-dimethylidene-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2.1~3,32~.1~3,33~.1~6,9~.1~12,16~.0~18,22~.0~29,36~.0~31,35~]hentetracontan-24-one (non-preferred name), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-[2,6-bis(fluoranyl)-4-[3-(methylamino)propoxy]phenyl]-5-chloranyl-N-[(2S)-1,1,1-tris(fluoranyl)propan-2-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ... | Authors: | Chen, L.J, Chen, Q, Yu, Y, Yang, J.H. | Deposit date: | 2020-12-18 | Release date: | 2021-07-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.446 Å) | Cite: | Cevipabulin-tubulin complex reveals a novel agent binding site on alpha-tubulin with tubulin degradation effect. Sci Adv, 7, 2021
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1OIB
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![BU of 1oib by Molmil](/molmil-images/mine/1oib) | |
1OVE
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![BU of 1ove by Molmil](/molmil-images/mine/1ove) | The structure of p38 alpha in complex with a dihydroquinolinone | Descriptor: | 1-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERIDIN-4-YL-3,4-DIHYDROQUINOLIN-2(1H)-ONE, GLYCEROL, Mitogen-activated protein kinase 14 | Authors: | Fitzgerald, C.E, Patel, S.B, Becker, J.W, Cameron, P.M, Zaller, D, Pikounis, V.B, O'Keefe, S.J, Scapin, G. | Deposit date: | 2003-03-26 | Release date: | 2003-09-02 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity Nat.Struct.Biol., 10, 2003
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7EAX
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![BU of 7eax by Molmil](/molmil-images/mine/7eax) | Crystal complex of p53-V272M and antimony ion | Descriptor: | ANTIMONY (III) ION, Cellular tumor antigen p53, ZINC ION | Authors: | Lu, M, Tang, Y. | Deposit date: | 2021-03-08 | Release date: | 2022-02-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Repurposing antiparasitic antimonials to noncovalently rescue temperature-sensitive p53 mutations. Cell Rep, 39, 2022
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6IET
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![BU of 6iet by Molmil](/molmil-images/mine/6iet) | The crystal structure of TRIM66 PHD-Bromo domain | Descriptor: | Tripartite motif-containing protein 66, ZINC ION | Authors: | Chen, J. | Deposit date: | 2018-09-17 | Release date: | 2019-09-18 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.101 Å) | Cite: | TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells. Nat Commun, 10, 2019
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6IEU
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![BU of 6ieu by Molmil](/molmil-images/mine/6ieu) | |
8UGC
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![BU of 8ugc by Molmil](/molmil-images/mine/8ugc) | |
6JAU
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![BU of 6jau by Molmil](/molmil-images/mine/6jau) | The complex structure of Pseudomonas aeruginosa MucA/MucB. | Descriptor: | CALCIUM ION, GLYCEROL, HEXAETHYLENE GLYCOL, ... | Authors: | Li, T, He, L.H, Li, C.C, Liu, L, Peng, C.T, Shen, Y.L, Qin, X.F, Xiao, Q.J, Zhu, Y.B, Song, Y.J, Zhao, N.l, Zhao, C, Yang, J, Mu, X.Y, Huang, Q, Bao, R. | Deposit date: | 2019-01-25 | Release date: | 2020-01-29 | Last modified: | 2020-08-19 | Method: | X-RAY DIFFRACTION (1.905 Å) | Cite: | Molecular basis of the lipid-induced MucA-MucB dissociation in Pseudomonas aeruginosa. Commun Biol, 3, 2020
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8DAD
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![BU of 8dad by Molmil](/molmil-images/mine/8dad) | SARS-CoV-2 receptor binding domain in complex with AZ090 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AZ090 Fab Heavy Chain, AZ090 Fab Light Chain, ... | Authors: | Zong, S, Wang, Z, Gaebler, C, Nussenzweig, M. | Deposit date: | 2022-06-13 | Release date: | 2022-08-24 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.85 Å) | Cite: | SARS-CoV-2 receptor binding domain in complex with AZ090 Fab To Be Published
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6JIJ
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8WD5
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![BU of 8wd5 by Molmil](/molmil-images/mine/8wd5) | |
8X0S
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![BU of 8x0s by Molmil](/molmil-images/mine/8x0s) | Crystal structure of r(G4C2)2 | Descriptor: | POTASSIUM ION, RNA (5'-R(*GP*GP*GP*GP*CP*CP*GP*GP*GP*GP*C)-3') | Authors: | Geng, Y, Liu, C, Cai, Q, Zhu, G. | Deposit date: | 2023-11-05 | Release date: | 2024-06-19 | Last modified: | 2024-07-31 | Method: | X-RAY DIFFRACTION (2.956 Å) | Cite: | Crystal structure of a tetrameric RNA G-quadruplex formed by hexanucleotide repeat expansions of C9orf72 in ALS/FTD. Nucleic Acids Res., 52, 2024
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7X28
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![BU of 7x28 by Molmil](/molmil-images/mine/7x28) | MERS-CoV spike complex with S41 neutralizing antibody Fab Class3 (2u1d RBD with 2Fab) | Descriptor: | Spike glycoprotein, antibody S41 heavy chain, antibody S41 light chain | Authors: | Zeng, J.W, Zhang, S.Y, Zhou, H.X, Wang, X.W. | Deposit date: | 2022-02-25 | Release date: | 2023-01-18 | Last modified: | 2023-01-25 | Method: | ELECTRON MICROSCOPY (2.49 Å) | Cite: | Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein. Front Microbiol, 13, 2022
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7XML
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![BU of 7xml by Molmil](/molmil-images/mine/7xml) | Cryo-EM structure of PEIP-Bs_enolase complex | Descriptor: | Enolase, MAGNESIUM ION, Putative gene 60 protein | Authors: | Li, S, Zhang, K. | Deposit date: | 2022-04-26 | Release date: | 2022-07-27 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Bacteriophage protein PEIP is a potent Bacillus subtilis enolase inhibitor. Cell Rep, 40, 2022
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7X26
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![BU of 7x26 by Molmil](/molmil-images/mine/7x26) | S41 neutralizing antibody Fab(MERS-CoV) | Descriptor: | Spike glycoprotein, antibody S41 heavy chain, antibody S41 light chain | Authors: | Zeng, J.W, Zhang, S.Y, Wang, X.W. | Deposit date: | 2022-02-25 | Release date: | 2022-11-09 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (3.685 Å) | Cite: | Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein. Front Microbiol, 13, 2022
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7X2A
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![BU of 7x2a by Molmil](/molmil-images/mine/7x2a) | MERS-CoV spike complex with S41 neutralizing antibody Fab Class1 (1u2d RBD with 1Fab) | Descriptor: | MERS-CoV Spike glycoprotein, antibody S41 heavy chain, antibody S41 light chain | Authors: | Zeng, J.W, Zhang, S.Y, Zhou, H.X, Wang, X.W. | Deposit date: | 2022-02-25 | Release date: | 2022-11-09 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (2.49 Å) | Cite: | Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein. Front Microbiol, 13, 2022
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7X29
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![BU of 7x29 by Molmil](/molmil-images/mine/7x29) | MERS-CoV spike complex with S41 neutralizing antibody Fab Class2 (1u2d RBD with 2Fab) | Descriptor: | Spike glycoprotein, antibody S41 heavy chain, antibody S41 light chain | Authors: | Zeng, J.W, Zhang, S.Y, Zhou, H.X, Wang, X.W. | Deposit date: | 2022-02-25 | Release date: | 2022-11-09 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (2.49 Å) | Cite: | Cryoelectron microscopy structures of a human neutralizing antibody bound to MERS-CoV spike glycoprotein. Front Microbiol, 13, 2022
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8IM0
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![BU of 8im0 by Molmil](/molmil-images/mine/8im0) | mCherry-LaM8 complex | Descriptor: | LaM8, MCherry fluorescent protein | Authors: | Liang, H, Liu, R, Ding, Y. | Deposit date: | 2023-03-05 | Release date: | 2023-06-21 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Structural Insights into the Binding of Red Fluorescent Protein mCherry-Specific Nanobodies. Int J Mol Sci, 24, 2023
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8ILX
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![BU of 8ilx by Molmil](/molmil-images/mine/8ilx) | mCherry-LaM3 complex | Descriptor: | LAM3, MCherry fluorescent protein | Authors: | Liang, H, Liu, R, Ding, Y. | Deposit date: | 2023-03-05 | Release date: | 2023-06-21 | Method: | X-RAY DIFFRACTION (3.29 Å) | Cite: | Structural Insights into the Binding of Red Fluorescent Protein mCherry-Specific Nanobodies. Int J Mol Sci, 24, 2023
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