Crystal Structure of PPARgamma with the ligand JO21

Summary for 4E4K

Related3B3K 3K8S 4E4Q
DescriptorPeroxisome proliferator-activated receptor gamma, (2S)-3-phenyl-2-{[2'-(propan-2-yl)biphenyl-4-yl]oxy}propanoic acid (3 entities in total)
Functional Keywordsbundle of alpha-helices and a small four-stranded beta-sheet, transcription factor, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight66108.54
Primary citation
Laghezza, A.,Pochetti, G.,Lavecchia, A.,Fracchiolla, G.,Faliti, S.,Piemontese, L.,Di Giovanni, C.,Iacobazzi, V.,Infantino, V.,Montanari, R.,Capelli, D.,Tortorella, P.,Loiodice, F.
New 2-(Aryloxy)-3-phenylpropanoic Acids as Peroxisome Proliferator-Activated Receptor alpha/gamma Dual Agonists Able To Upregulate Mitochondrial Carnitine Shuttle System Gene Expression.
J.Med.Chem., 56:60-72, 2013
PubMed: 23171045 (PDB entries with the same primary citation)
DOI: 10.1021/jm301018z
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.333496.4%5.8%15.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report