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8ETM
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BU of 8etm by Molmil
Human triacylglycerol synthesizing enzyme DGAT1 in complex with DGAT1IN1 inhibitor
Descriptor: Diacylglycerol O-acyltransferase 1, [(1S,4r)-4-{4-[(4S)-2-({[4-(trifluoromethoxy)phenyl]methyl}carbamoyl)imidazo[1,2-a]pyridin-6-yl]phenyl}cyclohexyl]acetic acid
Authors:Sui, X, Kun, W, Walther, T, Farese, R, Liao, M.
Deposit date:2022-10-17
Release date:2023-06-07
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis.
Nat Commun, 14, 2023
6XOG
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BU of 6xog by Molmil
Structure of SUMO1-ML786519 adduct bound to SAE
Descriptor: SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ...
Authors:Sintchak, M, Lane, W, Bump, N.
Deposit date:2020-07-07
Release date:2021-03-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.
J.Med.Chem., 64, 2021
6XOH
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BU of 6xoh by Molmil
Structure of SUMO1-ML00789344 adduct bound to SAE
Descriptor: SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ...
Authors:Sintchak, M, Lane, W, Bump, N.
Deposit date:2020-07-07
Release date:2021-03-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.226 Å)
Cite:Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.
J.Med.Chem., 64, 2021
6XOI
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BU of 6xoi by Molmil
Structure of SUMO1-ML00752641 adduct bound to SAE
Descriptor: SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ...
Authors:Sintchak, M, Lane, W, Bump, N.
Deposit date:2020-07-07
Release date:2021-03-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.
J.Med.Chem., 64, 2021
8FDW
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BU of 8fdw by Molmil
Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S2, ...
Authors:Zhang, J, Shi, W, Cai, Y.F, Zhu, H.S, Peng, H.Q, Voyer, J, Volloch, S.R, Cao, H, Mayer, M.L, Song, K.K, Xu, C, Lu, J.M, Chen, B.
Deposit date:2022-12-05
Release date:2023-05-10
Last modified:2023-07-26
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane.
Nature, 619, 2023
4TUM
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BU of 4tum by Molmil
Crystal structure of Ankyrin Repeat Domain of AKR2
Descriptor: Ankyrin repeat domain-containing protein 2
Authors:Gwon, G.H, Cho, Y.
Deposit date:2014-06-24
Release date:2014-09-24
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:An Ankyrin Repeat Domain of AKR2 Drives Chloroplast Targeting through Coincident Binding of Two Chloroplast Lipids.
Dev.Cell, 30, 2014
8EFP
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BU of 8efp by Molmil
CryoEM structure of GSDMB in complex with shigella IpaH7.8
Descriptor: Gasdermin-B, Probable E3 ubiquitin-protein ligase ipaH7.8
Authors:Wang, C, Ruan, J.
Deposit date:2022-09-08
Release date:2023-03-29
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis for GSDMB pore formation and its targeting by IpaH7.8.
Nature, 616, 2023
8ET1
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BU of 8et1 by Molmil
CryoEM structure of GSDMB pore without transmembrane beta-barrel
Descriptor: Isoform 1 of Gasdermin-B
Authors:Wang, C, Ruan, J.
Deposit date:2022-10-15
Release date:2023-03-29
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (4.48 Å)
Cite:Structural basis for GSDMB pore formation and its targeting by IpaH7.8.
Nature, 616, 2023
8ET2
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BU of 8et2 by Molmil
CryoEM structure of the GSDMB pore
Descriptor: Isoform 1 of Gasdermin-B
Authors:Wang, C, Ruan, J.
Deposit date:2022-10-15
Release date:2023-03-29
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (4.96 Å)
Cite:Structural basis for GSDMB pore formation and its targeting by IpaH7.8.
Nature, 616, 2023
7N85
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BU of 7n85 by Molmil
Inner ring spoke from the isolated yeast NPC
Descriptor: Nucleoporin ASM4, Nucleoporin NIC96, Nucleoporin NSP1, ...
Authors:Akey, C.W, Rout, M.P, Ouch, C, Echevarria, I, Fernandez-Martinez, J, Nudelman, I.
Deposit date:2021-06-13
Release date:2022-01-26
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (7.6 Å)
Cite:Comprehensive structure and functional adaptations of the yeast nuclear pore complex.
Cell, 185, 2022
7N84
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BU of 7n84 by Molmil
Double nuclear outer ring from the isolated yeast NPC
Descriptor: Nucleoporin 145c, Nucleoporin NUP120, Nucleoporin NUP133, ...
Authors:Akey, C.W, Rout, M.P, Ouch, C, Echevarria, I, Fernandez-Martinez, J, Nudelman, I.
Deposit date:2021-06-13
Release date:2022-01-26
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (11.6 Å)
Cite:Comprehensive structure and functional adaptations of the yeast nuclear pore complex.
Cell, 185, 2022
7N9F
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BU of 7n9f by Molmil
Structure of the in situ yeast NPC
Descriptor: Dynein light chain 1, cytoplasmic, Nucleoporin 145c, ...
Authors:Villa, E, Singh, D, Ludtke, S.J, Akey, C.W, Rout, M.P, Echeverria, I, Suslov, S.
Deposit date:2021-06-17
Release date:2022-01-26
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (37 Å)
Cite:Comprehensive structure and functional adaptations of the yeast nuclear pore complex.
Cell, 185, 2022
7T3A
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BU of 7t3a by Molmil
GATOR1-RAG-RAGULATOR - Inhibitory Complex
Descriptor: GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3, ...
Authors:Egri, S.B, Shen, K.
Deposit date:2021-12-07
Release date:2022-04-06
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
Mol.Cell, 82, 2022
7T3B
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BU of 7t3b by Molmil
GATOR1-RAG-RAGULATOR - GAP Complex
Descriptor: ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ...
Authors:Egri, S.B, Shen, K.
Deposit date:2021-12-07
Release date:2022-04-06
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
Mol.Cell, 82, 2022
7T3C
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BU of 7t3c by Molmil
GATOR1-RAG-RAGULATOR - Dual Complex
Descriptor: ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ...
Authors:Egri, S.B, Shen, K.
Deposit date:2021-12-07
Release date:2022-04-06
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism.
Mol.Cell, 82, 2022
7B42
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BU of 7b42 by Molmil
Crystal structure of c-MET bound by compound 8
Descriptor: 3-[(3-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine, Hepatocyte growth factor receptor
Authors:Collie, G.W.
Deposit date:2020-12-02
Release date:2020-12-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B3Q
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BU of 7b3q by Molmil
Crystal structure of c-MET bound by compound 1
Descriptor: 1-(phenylmethyl)-5~{H}-pyrrolo[3,2-c]pyridin-4-one, Hepatocyte growth factor receptor, SULFATE ION
Authors:Collie, G.W.
Deposit date:2020-12-01
Release date:2020-12-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B40
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BU of 7b40 by Molmil
Crystal structure of c-MET bound by compound 6
Descriptor: 3-(phenylmethyl)-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine, Hepatocyte growth factor receptor
Authors:Collie, G.W.
Deposit date:2020-12-01
Release date:2020-12-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B3W
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BU of 7b3w by Molmil
Crystal structure of c-MET bound by compound 4
Descriptor: 1,2-ETHANEDIOL, 3-(6-fluoranyl-1~{H}-indazol-4-yl)-4,5-dihydro-1~{H}-pyrrolo[3,4-b]pyrrol-6-one, Hepatocyte growth factor receptor
Authors:Collie, G.W.
Deposit date:2020-12-01
Release date:2020-12-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B43
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BU of 7b43 by Molmil
Crystal structure of c-MET bound by compound 9
Descriptor: 3-[(4-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine, Hepatocyte growth factor receptor
Authors:Collie, G.W.
Deposit date:2020-12-02
Release date:2020-12-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B3Z
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BU of 7b3z by Molmil
Crystal structure of c-MET bound by compound 5
Descriptor: 3-[3-(phenylmethyl)-1~{H}-pyrrolo[2,3-b]pyridin-5-yl]-4,5-dihydro-1~{H}-pyrrolo[3,4-b]pyrrol-6-one, DIMETHYL SULFOXIDE, Hepatocyte growth factor receptor
Authors:Collie, G.W.
Deposit date:2020-12-01
Release date:2020-12-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B3V
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BU of 7b3v by Molmil
Crystal structure of c-MET bound by compound 3
Descriptor: 3-(3-methyl-1~{H}-pyrrolo[2,3-b]pyridin-5-yl)-1~{H}-pyrrolo[3,4-b]pyrrol-6-one, Hepatocyte growth factor receptor
Authors:Collie, G.W.
Deposit date:2020-12-01
Release date:2020-12-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B44
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BU of 7b44 by Molmil
Crystal structure of c-MET bound by compound S1
Descriptor: 5-methoxy-1~{H}-indazole, DIMETHYL SULFOXIDE, Hepatocyte growth factor receptor, ...
Authors:Collie, G.W.
Deposit date:2020-12-02
Release date:2020-12-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B3T
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BU of 7b3t by Molmil
Crystal structure of c-MET bound by compound 2
Descriptor: 3-(phenylmethyl)-1~{H}-pyrrolo[2,3-b]pyridine, CHLORIDE ION, Hepatocyte growth factor receptor, ...
Authors:Collie, G.W.
Deposit date:2020-12-01
Release date:2020-12-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B41
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BU of 7b41 by Molmil
Crystal structure of c-MET bound by compound 7
Descriptor: 3-[(2-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine, Hepatocyte growth factor receptor
Authors:Collie, G.W.
Deposit date:2020-12-02
Release date:2020-12-09
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021

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