8KEE
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![BU of 8kee by Molmil](/molmil-images/mine/8kee) | Cyanophage A-1(L) sheath-tube | Descriptor: | sheath, tube | Authors: | Yu, R.C, Li, Q, Zhou, C.Z. | Deposit date: | 2023-08-11 | Release date: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | Structure of the intact tail machine of Anabaena myophage A-1(L). Nat Commun, 15, 2024
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8KEF
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8KEA
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![BU of 8kea by Molmil](/molmil-images/mine/8kea) | Cyanophage A-1(L) baseplate-initiators | Descriptor: | baseplate gp16, central spike, hub, ... | Authors: | Yu, R.C, Li, Q, Zhou, C.Z. | Deposit date: | 2023-08-11 | Release date: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Structure of the intact tail machine of Anabaena myophage A-1(L). Nat Commun, 15, 2024
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5Y20
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![BU of 5y20 by Molmil](/molmil-images/mine/5y20) | |
5YC4
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![BU of 5yc4 by Molmil](/molmil-images/mine/5yc4) | |
5YC3
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4JPW
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![BU of 4jpw by Molmil](/molmil-images/mine/4jpw) | Crystal structure of broadly and potently neutralizing antibody 12a21 in complex with hiv-1 strain 93th057 gp120 mutant | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HEAVY CHAIN OF ANTIBODY 12A21, ... | Authors: | Acharya, P, Luongo, T, Zhou, T, Kwong, P.D. | Deposit date: | 2013-03-19 | Release date: | 2013-04-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.904 Å) | Cite: | Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization. Cell(Cambridge,Mass.), 153, 2013
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7F7W
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![BU of 7f7w by Molmil](/molmil-images/mine/7f7w) | JAK2-JH2 | Descriptor: | 2-((1-(2-fluoro-4-((4-(1-isopropyl-1H-pyrazol-4-yl)-5-methylpyrimidin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)ethan-1-ol, Tyrosine-protein kinase JAK2 | Authors: | Niu, L. | Deposit date: | 2021-06-30 | Release date: | 2022-03-30 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2 V617F -induced myeloproliferative neoplasms. Blood Cancer J, 12, 2022
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6K81
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![BU of 6k81 by Molmil](/molmil-images/mine/6k81) | Crystal structure of human VASH1-SVBP complex | Descriptor: | Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1 | Authors: | Liu, X, Wang, H, Zhang, Y, Feng, Y. | Deposit date: | 2019-06-11 | Release date: | 2020-02-19 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structural insights into tubulin detyrosination by vasohibins-SVBP complex. Cell Discov, 5, 2019
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5VQF
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![BU of 5vqf by Molmil](/molmil-images/mine/5vqf) | Crystal Structure of pro-TGF-beta 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Transforming growth factor beta-1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Zhao, B, Xu, S, Dong, X, Lu, C, Springer, T.A. | Deposit date: | 2017-05-08 | Release date: | 2017-11-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Prodomain-growth factor swapping in the structure of pro-TGF-beta 1. J. Biol. Chem., 293, 2018
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7WJ6
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7WJ7
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7YFW
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![BU of 7yfw by Molmil](/molmil-images/mine/7yfw) | Cyanophage Pam3 fiber | Descriptor: | Pam3 fiber proreins | Authors: | Yang, F, Jiang, Y.L, Zhou, C.Z. | Deposit date: | 2022-07-09 | Release date: | 2023-01-18 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.96 Å) | Cite: | Fine structure and assembly pattern of a minimal myophage Pam3. Proc.Natl.Acad.Sci.USA, 120, 2023
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7YFZ
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![BU of 7yfz by Molmil](/molmil-images/mine/7yfz) | Cyanophage Pam3 baseplate proteins | Descriptor: | Pam3 baseplate wedge gp22, Pam3 baseplate wedge gp23, Pam3 hub gp19, ... | Authors: | Yang, F, Jiang, Y.L, Zhou, C.Z. | Deposit date: | 2022-07-09 | Release date: | 2023-01-18 | Last modified: | 2023-02-01 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Fine structure and assembly pattern of a minimal myophage Pam3. Proc.Natl.Acad.Sci.USA, 120, 2023
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5QBV
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![BU of 5qbv by Molmil](/molmil-images/mine/5qbv) | Crystal structure of human Cathepsin-S with bound ligand | Descriptor: | Cathepsin S, N-[2-chloro-5-(1-{3-[4-(6-chloro-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]propyl}-6-oxo-1,6-dihydropyridazin-3-yl)benzyl]benzamide | Authors: | Bembenek, S.D, Ameriks, M.K, Mirzadegan, T, Yang, H, Shao, C, Burley, S.K. | Deposit date: | 2017-08-04 | Release date: | 2017-12-20 | Last modified: | 2021-11-17 | Method: | X-RAY DIFFRACTION (1.796 Å) | Cite: | Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors Bioorg.Med.Chem.Lett., 20, 2010
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5QBY
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![BU of 5qby by Molmil](/molmil-images/mine/5qby) | Crystal structure of human Cathepsin-S with bound ligand | Descriptor: | Cathepsin S, N-[2-chloro-5-(1-{3-[4-(6-chloro-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]propyl}-6-oxo-1,6-dihydropyrimidin-5-yl)benzyl]-4-fluorobenzamide | Authors: | Bembenek, S.D, Ameriks, M.K, Mirzadegan, T, Yang, H, Shao, C, Burley, S.K. | Deposit date: | 2017-08-04 | Release date: | 2017-12-20 | Last modified: | 2021-11-17 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors Bioorg.Med.Chem.Lett., 20, 2010
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6JJZ
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![BU of 6jjz by Molmil](/molmil-images/mine/6jjz) | Crystal Structure of MAGI2 and Dendrin complex | Descriptor: | ACETATE ION, Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2, ... | Authors: | Lin, Z, Zhang, H, Yang, Z, Ji, Z, Zhang, M, Zhu, J. | Deposit date: | 2019-02-27 | Release date: | 2019-09-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity. Elife, 8, 2019
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7YLO
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![BU of 7ylo by Molmil](/molmil-images/mine/7ylo) | Conversion of indole-3-acetic acid into indole-3-aldehyde in bacteria Metabolic network of tryptophan around the indole-3-aldehyde formation | Descriptor: | Dyp-type peroxidase, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Cheng, J, Luo, Y, Zhu, J, Tan, R, Wang, N, Lebedev, A.A. | Deposit date: | 2022-07-26 | Release date: | 2023-07-05 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Conversion of indole-3-acetic acid into indole-3-aldehyde in bacteria
Metabolic network of tryptophan around the indole-3-aldehyde formation To Be Published
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2YER
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![BU of 2yer by Molmil](/molmil-images/mine/2yer) | Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors | Descriptor: | 1,2-ETHANEDIOL, 5-(HYDROXYMETHYL)-8-(1H-PYRROL-2-YL)-2H-[1,2,4]TRIAZOLO[4,3-A]QUINOLIN-1-ONE, SERINE/THREONINE-PROTEIN KINASE CHK1, ... | Authors: | Read, J.A, Breed, J, Haye, H, McCall, E, Vallentine, A, White, A, Otterbein, L. | Deposit date: | 2011-03-30 | Release date: | 2012-03-14 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Synthesis and Evaluation of Triazolones as Checkpoint Kinase 1 Inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
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2YEX
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![BU of 2yex by Molmil](/molmil-images/mine/2yex) | Synthesis and evaluation of triazolones as checkpoint kinase 1 inhibitors | Descriptor: | 5-METHYL-8-(1H-PYRROL-2-YL)[1,2,4]TRIAZOLO[4,3-A]QUINOLIN-1(2H)-ONE, GLYCEROL, SERINE/THREONINE-PROTEIN KINASE CHK1, ... | Authors: | Read, J.A, Breed, J, Haye, H, McCall, E, Vallentine, A, White, A. | Deposit date: | 2011-03-31 | Release date: | 2012-03-14 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Synthesis and Evaluation of Triazolones as Checkpoint Kinase 1 Inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
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9BFL
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2X8D
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![BU of 2x8d by Molmil](/molmil-images/mine/2x8d) | Discovery of a Novel Class of triazolones as Checkpoint Kinase Inhibitors - Hit to Lead Exploration | Descriptor: | 5-METHYL[1,2,4]TRIAZOLO[4,3-A]QUINOLIN-1(2H)-ONE, SERINE/THREONINE-PROTEIN KINASE CHK1, SULFATE ION | Authors: | Read, J.A, Breed, J, Haye, H, McCall, E, Rowsell, S, Vallentine, A, White, A. | Deposit date: | 2010-03-08 | Release date: | 2010-08-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Discovery of a Novel Class of Triazolones as Checkpoint Kinase Inhibitors-Hit to Lead Exploration. Bioorg.Med.Chem., 20, 2010
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2X8E
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![BU of 2x8e by Molmil](/molmil-images/mine/2x8e) | Discovery of a Novel Class of triazolones as Checkpoint Kinase Inhibitors - Hit to Lead Exploration | Descriptor: | 5-METHYL-8-PYRIDIN-4-YL[1,2,4]TRIAZOLO[4,3-A]QUINOLIN-1(2H)-ONE, SERINE/THREONINE-PROTEIN KINASE CHK1, SULFATE ION | Authors: | Read, J.A, Breed, J, Haye, H, McCall, E, Rowsell, S, Vallentine, A, White, A. | Deposit date: | 2010-03-09 | Release date: | 2010-08-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Discovery of a Novel Class of Triazolones as Checkpoint Kinase Inhibitors-Hit to Lead Exploration. Bioorg.Med.Chem., 20, 2010
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2X8I
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![BU of 2x8i by Molmil](/molmil-images/mine/2x8i) | Discovery of a Novel Class of triazolones as Checkpoint Kinase Inhibitors - Hit to Lead Exploration | Descriptor: | 7-(3-hydroxyphenyl)-5-methyl[1,2,4]triazolo[4,3-a]quinolin-1(2H)-one, GLYCEROL, SERINE/THREONINE-PROTEIN KINASE CHK1, ... | Authors: | Read, J.A, Breed, J, Haye, H, McCall, E, Otterbein, L, Vallentine, A, White, A. | Deposit date: | 2010-03-09 | Release date: | 2010-08-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Discovery of a Novel Class of Triazolones as Checkpoint Kinase Inhibitors-Hit to Lead Exploration. Bioorg.Med.Chem., 20, 2010
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7YRX
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