7F7W

JAK2-JH2

Summary for 7F7W

• Entry DOI: 10.2210/pdb7f7w/pdb
• Descriptor: Tyrosine-protein kinase JAK2, 2-((1-(2-fluoro-4-((4-(1-isopropyl-1H-pyrazol-4-yl)-5-methylpyrimidin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)ethan-1-ol (3 entities in total)
• Functional Keywords: jak2, jh2, inhibitor, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 64199.84

Authors

Niu, L. (deposition date: 2021-06-30, release date: 2022-03-30, Last modification date: 2023-11-29)

• Primary citation: Hu, M.,Yang, T.,Yang, L.,Niu, L.,Zhu, J.,Zhao, A.,Shi, M.,Yuan, X.,Tang, M.,Yang, J.,Pei, H.,Yang, Z.,Chen, Q.,Ye, H.,Niu, T.,Chen, L.; Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2 V617F -induced myeloproliferative neoplasms.; Blood Cancer J, 12:37-37, 2022; PubMed: 35256594; DOI: 10.1038/s41408-022-00628-2

Experimental method

X-RAY DIFFRACTION (1.83 Å)