7F7W
JAK2-JH2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Tyrosine-protein kinase JAK2 | polymer | 275 | 31632.3 | 2 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
| 2 | A, B | 2-((1-(2-fluoro-4-((4-(1-isopropyl-1H-pyrazol-4-yl)-5-methylpyrimidin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)ethan-1-ol | non-polymer | 467.6 | 2 | Chemie (36H) | |||
| 3 | water | water | 18.0 | 237 | Chemie (HOH) |
Sequence modifications
A, B: 536 - 810 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Phe 617 | Val 617 | variant |
| Ala 777 | Trp 777 | conflict |
| His 794 | Phe 794 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 63264.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 935.2 | |
| All* | Total formula weight | 64199.8 |
