7F7W

JAK2-JH2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tyrosine-protein kinase JAK2	polymer	275	31632.3	2	UniProt (O60674) Pfam (PF07714)	Homo sapiens (Human)	Janus kinase 2,JAK-2
2	C, D (A, B)	2-((1-(2-fluoro-4-((4-(1-isopropyl-1H-pyrazol-4-yl)-5-methylpyrimidin-2-yl)amino)phenyl)piperidin-4-yl)(methyl)amino)ethan-1-ol	non-polymer		467.6	2	Chemie (36H)
3	E, F (A, B)	water	water		18.0	237	Chemie (HOH)

Sequence modifications

A, B: 536 - 810 (UniProt: O60674)

PDB	External Database	Details
Phe 617	Val 617	variant
Ala 777	Trp 777	conflict
His 794	Phe 794	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	63264.7
Non-Polymers*	Number of molecules	2
	Total formula weight	935.2
All*	Total formula weight	64199.8

*Water molecules are not included.