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1YM2
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BU of 1ym2 by Molmil
Crystal structure of human beta secretase complexed with NVP-AUR200
Descriptor: Beta-secretase 1, NVP-AUR200 INHIBITOR
Authors:Hanessian, S, Yun, H, Hou, Y, Yang, G, Bayrakdarian, M, Therrien, E, Moitessier, N, Roggo, S, Veenstra, S.
Deposit date:2005-01-20
Release date:2006-01-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics
J.Med.Chem., 48, 2005
2ADU
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BU of 2adu by Molmil
Human Methionine Aminopeptidase Complex with 4-Aryl-1,2,3-triazole Inhibitor
Descriptor: 4-(3-METHYLPHENYL)-1H-1,2,3-TRIAZOLE, COBALT (II) ION, Methionine aminopeptidase 2
Authors:Kallander, L.S, Lu, Q, Chen, W, Tomaszek, T, Yang, G, Tew, D, Meek, T.D, Hofmann, G.A, Schulz-Pritchard, C.K, Smith, W.W, Janson, C.A, Ryan, M.D, Zhang, G.F, Johanson, K.O, Kirkpatrick, R.B, Ho, T.F, Fisher, P.W, Mattern, M.R, Johnson, R.K, Hansbury, M.J, Winkler, J.D, Ward, K.W, Veber, D.F, Thompson, S.K.
Deposit date:2005-07-20
Release date:2005-09-13
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:4-Aryl-1,2,3-triazole: A Novel Template for a Reversible Methionine Aminopeptidase 2 Inhibitor, Optimized To Inhibit Angiogenesis in Vivo
J.Med.Chem., 48, 2005
5ZOI
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BU of 5zoi by Molmil
Crystal Structure of alpha1,3-Fucosyltransferase
Descriptor: Alpha-(1,3)-fucosyltransferase FucT, [[(2S,3R,4S,5R)-5-(2-azanyl-6-oxidanylidene-1H-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2S,3S,4S,5R,6R)-6-methyl-3,4,5-tris(oxidanyl)oxan-2-yl] hydrogen phosphate
Authors:Tan, Y, Yang, G.
Deposit date:2018-04-13
Release date:2019-06-26
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Directed evolution of an alpha 1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method.
Sci Adv, 5, 2019
7YD3
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BU of 7yd3 by Molmil
Single-chain variable fragment of app 3D1 antibody
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Yan, L, Yang, G.
Deposit date:2022-07-03
Release date:2023-07-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Cross-reactive epitopes between HIV and Coronavirus revealed by 3D1
To Be Published
7YI6
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BU of 7yi6 by Molmil
bnAb 3D1 in complex with 6-mer HR1 peptide from HCoV-229E S protein
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Yan, L, Yang, G.
Deposit date:2022-07-15
Release date:2023-08-30
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Cross-reactive epitopes between HIV and Coronavirus revealed by 3D1
To Be Published
8IOY
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BU of 8ioy by Molmil
Structure of ATP7B C983S/C985S/D1027A mutant with AMP-PNP
Descriptor: Copper-transporting ATPase 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Yang, G, Xu, L, Guo, J, Wu, Z.
Deposit date:2023-03-13
Release date:2023-04-26
Last modified:2023-05-03
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structures of the human Wilson disease copper transporter ATP7B.
Cell Rep, 42, 2023
5EHT
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BU of 5eht by Molmil
Indirect contributions of mutations underlie optimization of new enzyme function
Descriptor: GLYCEROL, N-acyl homoserine lactonase, ZINC ION
Authors:Jackson, C.J, Hong, N.-S.
Deposit date:2015-10-28
Release date:2016-09-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Conformational Tinkering Drives Evolution of a Promiscuous Activity through Indirect Mutational Effects.
Biochemistry, 55, 2016
7D39
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BU of 7d39 by Molmil
FLR-apo
Descriptor: Cd1, FLAVIN MONONUCLEOTIDE
Authors:Hong, S, Yang, G.H, Zhang, P.
Deposit date:2020-09-18
Release date:2021-03-03
Method:X-RAY DIFFRACTION (2.198 Å)
Cite:Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria.
Nat Commun, 12, 2021
7D38
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BU of 7d38 by Molmil
flavone reductase
Descriptor: Cd1, FLAVIN MONONUCLEOTIDE, chrysin
Authors:Hong, S, Yang, G.H, Zhang, P.
Deposit date:2020-09-18
Release date:2021-03-03
Method:X-RAY DIFFRACTION (2.649 Å)
Cite:Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria.
Nat Commun, 12, 2021
7D3B
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BU of 7d3b by Molmil
flavone reductase
Descriptor: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, Cd1, FLAVIN MONONUCLEOTIDE
Authors:Hong, S, Yang, G.H, Zhang, P.
Deposit date:2020-09-18
Release date:2021-03-03
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria.
Nat Commun, 12, 2021
7D3A
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BU of 7d3a by Molmil
flavone reductase
Descriptor: 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, Cd1, FLAVIN MONONUCLEOTIDE
Authors:Hong, S, Yang, G.H, Zhang, P.
Deposit date:2020-09-18
Release date:2021-03-03
Last modified:2021-09-29
Method:X-RAY DIFFRACTION (2.552 Å)
Cite:Discovery of an ene-reductase for initiating flavone and flavonol catabolism in gut bacteria.
Nat Commun, 12, 2021
4N0S
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BU of 4n0s by Molmil
Complex of ERK2 with caffeic acid
Descriptor: CAFFEIC ACID, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ...
Authors:Kurinov, I, Malakhova, M.
Deposit date:2013-10-02
Release date:2014-08-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7992 Å)
Cite:Caffeic Acid Directly Targets ERK1/2 to Attenuate Solar UV-Induced Skin Carcinogenesis.
Cancer Prev Res (Phila), 7, 2014
1B6I
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BU of 1b6i by Molmil
T4 LYSOZYME MUTANT WITH CYS 54 REPLACED BY THR, CYS 97 REPLACED BY ALA, THR 21 REPLACED BY CYS AND LYS 124 REPLACED BY CYS (C54T,C97A,T21C,K124C)
Descriptor: 2-HYDROXYETHYL DISULFIDE, PROTEIN (LYSOZYME)
Authors:Vetter, I.R, Baase, W.A, Snow, S, Matthews, B.W.
Deposit date:1999-01-14
Release date:2000-01-12
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Solid-state synthesis and mechanical unfolding of polymers of T4 lysozyme.
Proc.Natl.Acad.Sci.USA, 97, 2000
7XUK
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BU of 7xuk by Molmil
Structure of ATP7B C983S/C985S/D1027A mutant in presence of ATOX1
Descriptor: Copper-transporting ATPase 2
Authors:Yang, G, Xu, L, Guo, J, Wu, Z.
Deposit date:2022-05-18
Release date:2023-04-26
Last modified:2023-05-03
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structures of the human Wilson disease copper transporter ATP7B.
Cell Rep, 42, 2023
7XUM
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BU of 7xum by Molmil
Structure of ATP7B C983S/C985S/D1027A mutant with Cu+ in presence of ATOX1
Descriptor: COPPER (II) ION, Copper-transporting ATPase 2
Authors:Yang, G, Xu, L, Chang, S, Guo, J, Wu, Z.
Deposit date:2022-05-19
Release date:2023-05-03
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structures of the human Wilson disease copper transporter ATP7B.
Cell Rep, 42, 2023
7XUN
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BU of 7xun by Molmil
Structure of ATP7B C983S/C985S/D1027A mutant
Descriptor: Copper-transporting ATPase 2
Authors:Yang, G, Xu, L, Guo, J, Wu, Z.
Deposit date:2022-05-19
Release date:2023-04-26
Last modified:2023-05-03
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structures of the human Wilson disease copper transporter ATP7B.
Cell Rep, 42, 2023
7XUO
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BU of 7xuo by Molmil
Structure of ATP7B C983S/C985S/D1027A mutant with cisplatin in presence of ATOX1
Descriptor: Copper-transporting ATPase 2, PLATINUM (II) ION
Authors:Yang, G, Xu, L, Chang, S, Guo, J, Wu, Z.
Deposit date:2022-05-19
Release date:2023-04-26
Last modified:2023-05-03
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structures of the human Wilson disease copper transporter ATP7B.
Cell Rep, 42, 2023
5QCS
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BU of 5qcs by Molmil
Crystal structure of BACE complex with BMC024
Descriptor: (2R,4S)-N-BUTYL-4-HYDROXY-2-METHYL- 4-((E)-(4AS,12R,15S,17AS)-15-METHYL -14,17-DIOXO-2,3,4,4A,6,9,11,12,13, 14,15,16,17,17A-TETRADECAHYDRO-1H-5 ,10-DITHIA-1,13,16-TRIAZA-BENZOCYCL OPENTADECEN-12-YL)-BUTYRAMIDE, Beta-secretase 1
Authors:Rondeau, J.M, Shao, C, Yang, H, Burley, S.K.
Deposit date:2017-12-01
Release date:2020-06-03
Last modified:2021-02-10
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:D3R grand challenge 4: blind prediction of protein-ligand poses, affinity rankings, and relative binding free energies.
J.Comput.Aided Mol.Des., 34, 2020
4PY4
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BU of 4py4 by Molmil
Crystal structure of human poly(ADP-ribose) polymerase 14, catalytic domain in complex with an inhibitor XL2
Descriptor: 2-({4-[(1R)-1-(dimethylamino)ethyl]phenyl}amino)-6-fluoro-1,3-benzothiazole-4-carboxamide, Poly [ADP-ribose] polymerase 14
Authors:Li, J, Xu, Y.
Deposit date:2014-03-26
Release date:2015-04-01
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:Palladium-catalyzed N-arylation of 2-aminobenzothiazole-4-carboxylates/carboxamides: facile synthesis of PARP14 inhibitors
Tetrahedron, 70, 2017
7PT2
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BU of 7pt2 by Molmil
Actinobacterial 2-hydroxyacyl-CoA lyase (AcHACL) mutant E493Q structure in complex with substrate 2-HIB-CoA and inactive cofactor 3-deaza-ThDP
Descriptor: 2-hydroxyacyl-CoA lyase, 2-{4-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-3-METHYLTHIOPHEN-2-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Zahn, M, Rohwerder, T.
Deposit date:2021-09-25
Release date:2022-02-02
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.762 Å)
Cite:Mechanistic details of the actinobacterial lyase-catalyzed degradation reaction of 2-hydroxyisobutyryl-CoA.
J.Biol.Chem., 298, 2022
7PT3
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BU of 7pt3 by Molmil
Actinobacterial 2-hydroxyacyl-CoA lyase (AcHACL) mutant E493A structure in complex with substrate 2-HIB-CoA and inactive cofactor 3-deaza-ThDP
Descriptor: 2-hydroxyacyl-CoA lyase, 2-{4-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-3-METHYLTHIOPHEN-2-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Zahn, M, Rohwerder, T.
Deposit date:2021-09-25
Release date:2022-02-02
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (1.625 Å)
Cite:Mechanistic details of the actinobacterial lyase-catalyzed degradation reaction of 2-hydroxyisobutyryl-CoA.
J.Biol.Chem., 298, 2022
7PT1
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BU of 7pt1 by Molmil
Actinobacterial 2-hydroxyacyl-CoA lyase (AcHACL) structure in complex with substrate 2-HIB-CoA and inactive cofactor 3-deaza-ThDP
Descriptor: 2-hydroxyacyl-CoA lyase, 2-{4-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-3-METHYLTHIOPHEN-2-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Zahn, M, Rohwerder, T.
Deposit date:2021-09-25
Release date:2022-02-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.553 Å)
Cite:Mechanistic details of the actinobacterial lyase-catalyzed degradation reaction of 2-hydroxyisobutyryl-CoA.
J.Biol.Chem., 298, 2022
7PT4
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BU of 7pt4 by Molmil
Actinobacterial 2-hydroxyacyl-CoA lyase (AcHACL) structure in complex with a covalently bound reaction intermediate as well as products formyl-CoA and acetone
Descriptor: 2-hydroxyacyl-CoA lyase, 3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-2-{(1R,11R,15S,17R)-19-[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]-1,11,15,17-TETRAHYDROXY-12,12-DIMETHYL-15,17-DIOXIDO-6,10-DIOXO-14,16,18-TRIOXA-2-THIA-5,9-DIAZA-15,17-DIPHOSPHANONADEC-1-YL}-5-(2-{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}ETHYL)-4-METHYL-1,3-THIAZOL-3-IUM, ACETONE, ...
Authors:Zahn, M, Rohwerder, T.
Deposit date:2021-09-25
Release date:2022-02-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Mechanistic details of the actinobacterial lyase-catalyzed degradation reaction of 2-hydroxyisobutyryl-CoA.
J.Biol.Chem., 298, 2022
7FCV
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BU of 7fcv by Molmil
Cryo-EM structure of the Potassium channel AKT1 mutant from Arabidopsis thaliana
Descriptor: PHOSPHATIDYLETHANOLAMINE, POTASSIUM ION, Potassium channel AKT1
Authors:Yang, G.H, Lu, Y.M, Jia, Y.T, Zhang, Y.M, Tang, R.F, Xu, X, Li, X.M, Lei, J.L.
Deposit date:2021-07-15
Release date:2022-11-09
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for the activity regulation of a potassium channel AKT1 from Arabidopsis.
Nat Commun, 13, 2022
8I71
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BU of 8i71 by Molmil
Hepatitis B virus core protein Y132A mutant in complex with Linvencorvir (RG7907), a Hepatitis B Virus (HBV) Core Protein Allosteric Modulator (CpAM)
Descriptor: 3-[(8~{a}~{S})-7-[[5-ethoxycarbonyl-4-(3-fluoranyl-2-methyl-phenyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-3-oxidanylidene-5,6,8,8~{a}-tetrahydro-1~{H}-imidazo[1,5-a]pyrazin-2-yl]-2,2-dimethyl-propanoic acid, CHLORIDE ION, Capsid protein, ...
Authors:Zhou, Z, Xu, Z.H.
Deposit date:2023-01-30
Release date:2023-03-22
Last modified:2023-04-05
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery of Linvencorvir (RG7907), a Hepatitis B Virus Core Protein Allosteric Modulator, for the Treatment of Chronic HBV Infection.
J.Med.Chem., 66, 2023

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