4PY4
Crystal structure of human poly(ADP-ribose) polymerase 14, catalytic domain in complex with an inhibitor XL2
Summary for 4PY4
Entry DOI | 10.2210/pdb4py4/pdb |
Descriptor | Poly [ADP-ribose] polymerase 14, 2-({4-[(1R)-1-(dimethylamino)ethyl]phenyl}amino)-6-fluoro-1,3-benzothiazole-4-carboxamide (3 entities in total) |
Functional Keywords | rossmann fold, catalyze the post-translational modification of proteins, using b-nad+, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : Q460N5 |
Total number of polymer chains | 2 |
Total formula weight | 44024.93 |
Authors | |
Primary citation | Wang, P.,Li, J.,Jiang, X.,Liu, Z.,Ye, N.,Xu, Y.,Yang, G.,Xu, Y.,Zhang, A. Palladium-catalyzed N-arylation of 2-aminobenzothiazole-4-carboxylates/carboxamides: facile synthesis of PARP14 inhibitors Tetrahedron, 70:5666-5673, 2017 Cited by DOI: 10.1016/j.tet.2014.06.064PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.76 Å) |
Structure validation
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