2NTA
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![BU of 2nta by Molmil](/molmil-images/mine/2nta) | Crystal Structure of PTP1B-inhibitor Complex | Descriptor: | 5-(4-CHLORO-5-PHENYL-3-THIENYL)-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE, Tyrosine-protein phosphatase non-receptor type 1 | Authors: | Xu, W, Follows, B. | Deposit date: | 2006-11-07 | Release date: | 2007-04-17 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Probing acid replacements of thiophene PTP1B inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
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1ZNI
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![BU of 1zni by Molmil](/molmil-images/mine/1zni) | INSULIN | Descriptor: | CHLORIDE ION, INSULIN, ZINC ION | Authors: | Turkenburg, M.G.W, Whittingham, J.L, Dodson, G.G, Dodson, E.J, Xiao, B, Bentley, G.A. | Deposit date: | 1997-09-23 | Release date: | 1998-01-28 | Last modified: | 2018-07-04 | Method: | X-RAY DIFFRACTION (1.498 Å) | Cite: | Structure of insulin in 4-zinc insulin. Nature, 261, 1976
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2NT7
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![BU of 2nt7 by Molmil](/molmil-images/mine/2nt7) | Crystal structure of PTP1B-inhibitor complex | Descriptor: | Tyrosine-protein phosphatase non-receptor type 1, {[5-(3-{[1-(BENZYLSULFONYL)PIPERIDIN-4-YL]AMINO}PHENYL)-4-BROMO-2-(2H-TETRAZOL-5-YL)-3-THIENYL]OXY}ACETIC ACID | Authors: | Xu, W, Follows, B. | Deposit date: | 2006-11-07 | Release date: | 2007-04-17 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Probing acid replacements of thiophene PTP1B inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
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3KQ6
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![BU of 3kq6 by Molmil](/molmil-images/mine/3kq6) | Enhancing the Therapeutic Properties of a Protein by a Designed Zinc-Binding Site, Structural principles of a novel long-acting insulin analog | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | Authors: | Wan, Z.L, Hu, S.Q, Whittaker, L, Phillips, N.B, Whittake, J, Ismail-Beigi, F, Weiss, M.A. | Deposit date: | 2009-11-17 | Release date: | 2010-02-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot. J.Biol.Chem., 285, 2010
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3FQ9
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![BU of 3fq9 by Molmil](/molmil-images/mine/3fq9) | Design of an insulin analog with enhanced receptor-binding selectivity. Rationale, structure, and therapeutic implications | Descriptor: | Insulin, ZINC ION | Authors: | Zhao, M, Wan, Z.L, Whittaker, L, Xu, B, Phillips, N, Katsoyannis, P, Whittaker, J, Weiss, M.A. | Deposit date: | 2009-01-07 | Release date: | 2009-08-04 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications. J.Biol.Chem., 284, 2009
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2H1Z
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5HMS
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![BU of 5hms by Molmil](/molmil-images/mine/5hms) | X-ray structure of human recombinant 5-aminolaevulinic acid dehydratase (hrALAD). | Descriptor: | Delta-aminolevulinic acid dehydratase, ZINC ION | Authors: | Butler, D, Erskine, P.T, Cooper, J.B, Shoolingin-Jordan, P.M. | Deposit date: | 2016-01-17 | Release date: | 2016-01-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural studies of substrate and product complexes of 5-aminolaevulinic acid dehydratase from humans, Escherichia coli and the hyperthermophile Pyrobaculum calidifontis. Acta Crystallogr D Struct Biol, 73, 2017
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3GKY
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![BU of 3gky by Molmil](/molmil-images/mine/3gky) | The Structural Basis of an ER Stress-Associated Bottleneck in a Protein Folding Landscape | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | Authors: | Liu, M, Wan, Z.L, Chu, Y.C, Alddin, H, Klaproth, B, Weiss, M.A. | Deposit date: | 2009-03-11 | Release date: | 2009-03-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of a "nonfoldable" insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY. J.Biol.Chem., 284, 2009
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2YEP
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![BU of 2yep by Molmil](/molmil-images/mine/2yep) | STRUCTURE OF AN N-TERMINAL NUCLEOPHILE (NTN) HYDROLASE, OAT2, IN COMPLEX WITH GLUTAMATE | Descriptor: | ACETATE ION, GLUTAMATE N-ACETYLTRANSFERASE 2 ALPHA CHAIN, GLUTAMATE N-ACETYLTRANSFERASE 2 BETA CHAIN, ... | Authors: | Chowdhury, R, Iqbal, A, Clifton, I.J, Schofield, C.J. | Deposit date: | 2011-03-29 | Release date: | 2011-09-07 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural and Biochemical Analyses Reveal How Ornithine Acetyl Transferase Binds Acidic and Basic Amino Acid Substrates. Org.Biomol.Chem., 9, 2011
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3BDW
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![BU of 3bdw by Molmil](/molmil-images/mine/3bdw) | Human CD94/NKG2A | Descriptor: | NKG2-A/NKG2-B type II integral membrane protein, Natural killer cells antigen CD94 | Authors: | Sullivan, L.C, Clements, C.S. | Deposit date: | 2007-11-15 | Release date: | 2008-01-01 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The Heterodimeric Assembly of the CD94-NKG2 Receptor Family and Implications for Human Leukocyte Antigen-E Recognition Immunity, 27, 2007
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6HKS
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![BU of 6hks by Molmil](/molmil-images/mine/6hks) | |
3BON
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![BU of 3bon by Molmil](/molmil-images/mine/3bon) | |
6JSJ
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![BU of 6jsj by Molmil](/molmil-images/mine/6jsj) | |
3BOO
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![BU of 3boo by Molmil](/molmil-images/mine/3boo) | |
3BOK
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![BU of 3bok by Molmil](/molmil-images/mine/3bok) | |
2ERL
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![BU of 2erl by Molmil](/molmil-images/mine/2erl) | PHEROMONE ER-1 FROM | Descriptor: | ETHANOL, MATING PHEROMONE ER-1 | Authors: | Anderson, D.H, Weiss, M.S, Eisenberg, D. | Deposit date: | 1995-12-20 | Release date: | 1996-07-11 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | A challenging case for protein crystal structure determination: the mating pheromone Er-1 from Euplotes raikovi. Acta Crystallogr.,Sect.D, 52, 1996
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3UPU
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![BU of 3upu by Molmil](/molmil-images/mine/3upu) | Crystal structure of the T4 Phage SF1B Helicase Dda | Descriptor: | 5'-D(*TP*TP*TP*TP*TP*TP*TP*T)-3', ATP-dependent DNA helicase dda | Authors: | He, X, Yun, M.K, Pemble IV, C.W, Kreuzer, K.N, Raney, K.D, White, S.W. | Deposit date: | 2011-11-18 | Release date: | 2012-06-20 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (3.299 Å) | Cite: | The T4 Phage SF1B Helicase Dda Is Structurally Optimized to Perform DNA Strand Separation. Structure, 20, 2012
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5BP7
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![BU of 5bp7 by Molmil](/molmil-images/mine/5bp7) | Crystal structure of SAM-dependent methyltransferase from Geobacter sulfurreducens in complex with S-Adenosyl-L-homocysteine | Descriptor: | CHLORIDE ION, S-ADENOSYL-L-HOMOCYSTEINE, SAM-dependent methyltransferase | Authors: | Kutner, J, Shabalin, I.G, Mason, D.V, Handing, K.B, Gasiorowska, O.A, Bonanno, J, Seidel, R, Almo, S.C, Minor, W, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2015-05-27 | Release date: | 2015-06-10 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of SAM-dependent methyltransferase from Geobacter sulfurreducens in complex with S-Adenosyl-L-homocysteine to be published
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7ZQ8
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![BU of 7zq8 by Molmil](/molmil-images/mine/7zq8) | VelcroVax tandem HBcAg with SUMO-Affimer inserted at MIR (T=4 VLP) | Descriptor: | VelcroVax tandem HBcAg with SUMO-Affimer inserted at MIR | Authors: | Kingston, N.J, Grehan, K, Snowden, J.S, Alzahrani, J, Ranson, N.A, Rowlands, D.J, Stonehouse, N.J. | Deposit date: | 2022-04-29 | Release date: | 2023-01-18 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | VelcroVax: a "Bolt-On" Vaccine Platform for Glycoprotein Display. Msphere, 8, 2023
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7ZQA
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![BU of 7zqa by Molmil](/molmil-images/mine/7zqa) | VelcroVax tandem HBcAg with SUMO-Affimer inserted at MIR (T=3* VLP) | Descriptor: | VelcroVax tandem HBcAg with SUMO-Affimer inserted at MIR | Authors: | Kingston, N.J, Grehan, K, Snowden, J.S, Alzahrani, J, Ranson, N.A, Rowlands, D.J, Stonehouse, N.J. | Deposit date: | 2022-04-29 | Release date: | 2023-01-18 | Last modified: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | VelcroVax: a "Bolt-On" Vaccine Platform for Glycoprotein Display. Msphere, 8, 2023
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6BB3
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![BU of 6bb3 by Molmil](/molmil-images/mine/6bb3) | |
6BB1
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![BU of 6bb1 by Molmil](/molmil-images/mine/6bb1) | Lactate Dehydrogenase in complex with inhibitor (R)-5-((2-chlorophenyl)thio)-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro-[2,2'-bipyridin]-6(1H)-one | Descriptor: | (2R)-5-[(2-chlorophenyl)sulfanyl]-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro[2,2'-bipyridin]-6(1H)-one, L-lactate dehydrogenase A chain, LACTIC ACID, ... | Authors: | Ultsch, M, Eigenbrot, C. | Deposit date: | 2017-10-16 | Release date: | 2018-10-24 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published
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6BB2
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![BU of 6bb2 by Molmil](/molmil-images/mine/6bb2) | Lactate Dehydrogenase in complex with inhibitor (S)-5-((2-chlorophenyl)thio)-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro-[2,2'-bipyridin]-6(1H)-one | Descriptor: | (2S)-5-[(2-chlorophenyl)sulfanyl]-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro[2,2'-bipyridin]-6(1H)-one, L-lactate dehydrogenase A chain, LACTIC ACID, ... | Authors: | Ultsch, M, Eigenbrot, C. | Deposit date: | 2017-10-16 | Release date: | 2018-10-24 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published
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5FP9
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![BU of 5fp9 by Molmil](/molmil-images/mine/5fp9) | |
6BAG
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![BU of 6bag by Molmil](/molmil-images/mine/6bag) | Lactate Dehydrogenase in complex with inhibitor (R)-5-((2-chlorophenyl)thio)-6'-((4-fluorophenyl)amino)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro-[2,2'-bipyridin]-6(1H)-one | Descriptor: | (2R)-5-[(2-chlorophenyl)sulfanyl]-6'-[(4-fluorophenyl)amino]-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro[2,2'-bipyridin]-6(1H)-one, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, L-lactate dehydrogenase A chain, ... | Authors: | Ultsch, M, Eigenbrot, C. | Deposit date: | 2017-10-12 | Release date: | 2018-10-17 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published
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