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8CX1
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BU of 8cx1 by Molmil
Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 1
Descriptor: Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ...
Authors:Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D.
Deposit date:2022-05-19
Release date:2023-02-15
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
Nature, 615, 2023
7FBI
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BU of 7fbi by Molmil
Cryo-EM structure of EBV gB in complex with nAbs 3A3 and 3A5
Descriptor: 3A3 heavy chain, 3A3 light chain, 3A5 heavy chain, ...
Authors:Zheng, Q, Li, S, Zha, Z, Hong, J, Chen, Y, Zhang, X.
Deposit date:2021-07-10
Release date:2022-07-13
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structure of EBV gB in complex with nAbs 3A3 and 3A5
To Be Published
1EV7
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BU of 1ev7 by Molmil
CRYSTAL STRUCTURE OF DNA RESTRICTION ENDONUCLEASE NAEI
Descriptor: TYPE IIE RESTRICTION ENDONUCLEASE NAEI
Authors:Huai, Q, Colandene, J.D, Chen, Y, Luo, F, Zhao, Y.
Deposit date:2000-04-19
Release date:2000-10-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal structure of NaeI-an evolutionary bridge between DNA endonuclease and topoisomerase.
EMBO J., 19, 2000
4L9U
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BU of 4l9u by Molmil
Structure of C-terminal coiled coil of RasGRP1
Descriptor: GLYCEROL, RAS guanyl-releasing protein 1, SULFATE ION
Authors:Iwig, J.S, Vercoulen, Y, Das, R, Barros, T, Limnander, A, Che, Y, Pelton, J.G, Wemmer, D.E, Roose, J.P, Kuriyan, J.
Deposit date:2013-06-18
Release date:2013-08-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.6014 Å)
Cite:Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1.
Elife, 2, 2013
4L9M
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BU of 4l9m by Molmil
Autoinhibited state of the Ras-specific exchange factor RasGRP1
Descriptor: CITRIC ACID, GLYCEROL, RAS guanyl-releasing protein 1, ...
Authors:Iwig, J.S, Vercoulen, Y, Das, R, Barros, T, Limnander, A, Che, Y, Pelton, J.G, Wemmer, D.E, Roose, J.P, Kuriyan, J.
Deposit date:2013-06-18
Release date:2013-08-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1.
Elife, 2, 2013
1DT1
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BU of 1dt1 by Molmil
THERMUS THERMOPHILUS CYTOCHROME C552 SYNTHESIZED BY ESCHERICHIA COLI
Descriptor: CYTOCHROME C552, HEME C
Authors:Fee, J.A, Chen, Y, Hill, M.J, Gomez-Moran, E, Loehr, T, Ai, J, Thony-Meyer, L, Williams, P.A, Stura, E, Sridhar, V, McRee, D.E.
Deposit date:2000-01-10
Release date:2000-02-18
Last modified:2021-03-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Integrity of thermus thermophilus cytochrome c552 synthesized by Escherichia coli cells expressing the host-specific cytochrome c maturation genes, ccmABCDEFGH: biochemical, spectral, and structural characterization of the recombinant protein.
Protein Sci., 9, 2000
5K5S
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BU of 5k5s by Molmil
Crystal structure of the active form of human calcium-sensing receptor extracellular domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Extracellular calcium-sensing receptor, ...
Authors:Geng, Y, Mosyak, L, Kurinov, I, Zuo, H, Sturchler, E, Cheng, T.C, Subramanyam, P, Brown, A.P, Brennan, S.C, Mun, H.-C, Bush, M, Chen, Y, Nguyen, T, Cao, B, Chang, D, Quick, M, Conigrave, A, Colecraft, H.M, McDonald, P, Fan, Q.R.
Deposit date:2016-05-23
Release date:2016-08-03
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural mechanism of ligand activation in human calcium-sensing receptor.
Elife, 5, 2016
7PKS
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BU of 7pks by Molmil
Structural basis of Integrator-mediated transcription regulation
Descriptor: DNA Template, DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, ...
Authors:Fianu, I, Chen, Y, Dienemann, C, Cramer, P.
Deposit date:2021-08-26
Release date:2021-12-08
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural basis of Integrator-mediated transcription regulation.
Science, 374, 2021
5K5T
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BU of 5k5t by Molmil
Crystal structure of the inactive form of human calcium-sensing receptor extracellular domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Extracellular calcium-sensing receptor, ...
Authors:Geng, Y, Mosyak, L, Kurinov, I, Zuo, H, Sturchler, E, Cheng, T.C, Subramanyam, P, Brown, A.P, Brennan, S.C, Mun, H.-C, Bush, M, Chen, Y, Nguyen, T, Cao, B, Chang, D, Quick, M, Conigrave, A, Colecraft, H.M, McDonald, P, Fan, Q.R.
Deposit date:2016-05-23
Release date:2016-08-03
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural mechanism of ligand activation in human calcium-sensing receptor.
Elife, 5, 2016
8V7L
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BU of 8v7l by Molmil
Cryo-EM structure of singly-bound SNF2h-nucleosome complex with SNF2h at inactive SHL2 (conformation 2)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Histone H2A type 1, Histone H2B, ...
Authors:Chio, U.S, Palovcak, E, Armache, J.P, Narlikar, G.J, Cheng, Y.
Deposit date:2023-12-04
Release date:2024-03-20
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking.
Nat Commun, 15, 2024
8CXB
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BU of 8cxb by Molmil
Human PA28-20S (PA28-4a3b)
Descriptor: Proteasome activator complex subunit 1, Proteasome activator complex subunit 2, Proteasome subunit alpha type-1, ...
Authors:Zhao, J, Makhija, S, Huang, B, Cheng, Y.
Deposit date:2022-05-20
Release date:2022-11-02
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins.
Proc.Natl.Acad.Sci.USA, 119, 2022
8V6V
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BU of 8v6v by Molmil
Cryo-EM structure of doubly-bound SNF2h-nucleosome complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Histone H2A type 1, Histone H2B, ...
Authors:Chio, U.S, Palovcak, E, Armache, J.P, Narlikar, G.J, Cheng, Y.
Deposit date:2023-12-03
Release date:2024-03-20
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking.
Nat Commun, 15, 2024
8V4Y
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BU of 8v4y by Molmil
Cryo-EM structure of singly-bound SNF2h-nucleosome complex with SNF2h at inactive SHL2 (conformation 1)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Histone H2A type 1, ...
Authors:Chio, U.S, Palovcak, E, Armache, J.P, Narlikar, G.J, Cheng, Y.
Deposit date:2023-11-29
Release date:2024-03-20
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking.
Nat Commun, 15, 2024
6WTT
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BU of 6wtt by Molmil
Crystals Structure of the SARS-CoV-2 (COVID-19) main protease with inhibitor GC-376
Descriptor: (1R,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase, ...
Authors:Sacco, M, Ma, C, Chen, Y, Wang, J.
Deposit date:2020-05-03
Release date:2020-05-20
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease.
Cell Res., 30, 2020
8D1P
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BU of 8d1p by Molmil
Crystal structure of Plasmodium falciparum GRP78-NBD in complex with 7-Deaza-2'-C-methyladenosine
Descriptor: 7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Chaperone DnaK, SULFATE ION
Authors:Mrozek, A, Chen, Y, Antoshchenko, T, Park, H.W.
Deposit date:2022-05-27
Release date:2023-05-31
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues.
Front Mol Biosci, 9, 2022
8D1S
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BU of 8d1s by Molmil
Crystal structure of Plasmodium falciparum GRP78 in complex with Toyocamycin
Descriptor: 4-amino-7-(beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Chaperone DnaK, SULFATE ION
Authors:Mrozek, A, Chen, Y, Antoshchenko, T, Park, H.W.
Deposit date:2022-05-27
Release date:2023-05-31
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues.
Front Mol Biosci, 9, 2022
8D1Q
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BU of 8d1q by Molmil
Crystal structure of Plasmodium falciparum GRP78-NBD in complex with 8-Aminoadenosine
Descriptor: (2R,3R,4S,5R)-2-(6,8-diaminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol, Chaperone DnaK, SULFATE ION
Authors:Mrozek, A, Chen, Y, Antoshchenko, T, Park, H.W.
Deposit date:2022-05-27
Release date:2023-05-31
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues.
Front Mol Biosci, 9, 2022
7MN2
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BU of 7mn2 by Molmil
Rules for designing protein fold switches and their implications for the folding code
Descriptor: Sb2
Authors:He, Y, Chen, Y, Ruan, B, Choi, J, Chen, Y, Motabar, D, Solomon, T, Simmerman, R, Kauffman, T, Gallagher, T, Bryan, P, Orban, J.
Deposit date:2021-04-30
Release date:2022-05-18
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Design and characterization of a protein fold switching network.
Nat Commun, 14, 2023
7MP7
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BU of 7mp7 by Molmil
Rules for designing protein fold switches and their implications for the folding code
Descriptor: Sb3
Authors:He, Y, Chen, Y, Ruan, B, Choi, J, Chen, Y, Motabar, D, Solomon, T, Simmerman, R, Kauffman, T, Gallagher, T, Bryan, P, Orban, J.
Deposit date:2021-05-04
Release date:2022-05-18
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Design and characterization of a protein fold switching network.
Nat Commun, 14, 2023
7MN1
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BU of 7mn1 by Molmil
Rules for designing protein fold switches and their implications for the folding code
Descriptor: Sa1
Authors:He, Y, Chen, Y, Ruan, B, Choi, J, Chen, Y, Motabar, D, Solomon, T, Simmerman, R, Kauffman, T, Gallagher, T, Bryan, P, Orban, J.
Deposit date:2021-04-30
Release date:2022-05-18
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Design and characterization of a protein fold switching network.
Nat Commun, 14, 2023
7MQ4
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BU of 7mq4 by Molmil
Rules for designing protein fold switches and their implications for the folding code
Descriptor: Sb1
Authors:He, Y, Chen, Y, Ruan, B, Choi, J, Chen, Y, Motabar, D, Solomon, T, Simmerman, R, Kauffman, T, Gallagher, T, Bryan, P, Orban, J.
Deposit date:2021-05-05
Release date:2022-05-18
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Design and characterization of a protein fold switching network.
Nat Commun, 14, 2023
6DFO
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BU of 6dfo by Molmil
Crystal structure of human GRP78 in complex with 8-bromoadenosine
Descriptor: 8-bromoadenosine, Endoplasmic reticulum chaperone BiP
Authors:Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W.
Deposit date:2018-05-15
Release date:2019-05-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Crystal structure of human GRP78 in complex with 8-bromoadenosine
To be Published
6DO2
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BU of 6do2 by Molmil
Crystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine
Descriptor: 7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Endoplasmic reticulum chaperone BiP
Authors:Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W.
Deposit date:2018-06-08
Release date:2019-06-12
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine
To Be Published
6DFM
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BU of 6dfm by Molmil
Crystal structure of human GRP78 in complex with 8-aminoadenosine
Descriptor: (2R,3R,4S,5R)-2-(6,8-diaminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol, Endoplasmic reticulum chaperone BiP
Authors:Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W.
Deposit date:2018-05-15
Release date:2019-05-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal structure of human GRP78 in complex with 8-aminoadenosine
To be Published
6XFN
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BU of 6xfn by Molmil
Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with UAW243
Descriptor: 3C-like proteinase, GLYCEROL, UAW243
Authors:Sacco, M, Ma, C, Wang, J, Chen, Y.
Deposit date:2020-06-15
Release date:2020-06-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L.
Sci Adv, 6, 2020

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