7XD6
| The Tet-S2 state with a pseudoknotted 4-way junction of wild-type Tetrahymena group I intron with 30nt 3'/5'-exon | Descriptor: | MAGNESIUM ION, SPERMIDINE, The Tet-S2 state with a pseudoknotted 4-way junction molecule of co-transcriptional folded wild-type Tetrahymena group I intron with 30nt 3'/5'-exon (5'-exon), ... | Authors: | Luo, B, Zhang, C, Ling, X, Mukherjee, S, Jia, G, Xie, J, Jia, X, Liu, L, Baulin, E.F, Luo, Y, Jiang, L, Dong, H, Wei, X, Bujnicki, J.M, Su, Z. | Deposit date: | 2022-03-26 | Release date: | 2023-04-05 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Cryo-EM reveals dynamics of Tetrahymena group I intron self-splicing Nat Catal, 2023
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7WD4
| Crystal structure of the Ilheus virus helicase: implications for enzyme function and drug design | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, NS3 helicase | Authors: | Wang, D.P, Wang, M.Y, Zhou, X, Wang, W.M, Cao, J.M. | Deposit date: | 2021-12-21 | Release date: | 2023-01-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal structure of the Ilheus virus helicase: implications for enzyme function and drug design To Be Published
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7UAD
| Crystal structure of human PTPN2 with inhibitor ABBV-CLS-484 | Descriptor: | 5-{(7R)-1-fluoro-3-hydroxy-7-[(3-methylbutyl)amino]-5,6,7,8-tetrahydronaphthalen-2-yl}-1lambda~6~,2,5-thiadiazolidine-1,1,3-trione, Tyrosine-protein phosphatase non-receptor type 2 | Authors: | Longenecker, K.L, Qiu, W, Sun, Q, Frost, J.M. | Deposit date: | 2022-03-12 | Release date: | 2023-07-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.044 Å) | Cite: | The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity. Nature, 622, 2023
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7Z0N
| Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators | Descriptor: | CALCIUM ION, GLYCEROL, IODIDE ION, ... | Authors: | Salgado-Polo, F, Clark, J.M, Macdonald, S.J.F, Barrett, T.N, Perrakis, A, Jamieson, A. | Deposit date: | 2022-02-23 | Release date: | 2022-05-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators. J.Med.Chem., 65, 2022
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7ZAN
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7YX5
| Structure of the Mimivirus genomic fibre in its relaxed 5-start helix form | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Putative glucose-methanol-choline oxidoreductase protein | Authors: | Villalta, A, Schmitt, A, Estrozi, L.F, Quemin, E.R.J, Alempic, J.M, Lartigue, A, Prazak, V, Belmudes, L, Vasishtan, D, Colmant, A.M.G, Honore, F.A, Coute, Y, Grunewald, K, Abergel, C. | Deposit date: | 2022-02-15 | Release date: | 2022-08-10 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | The giant mimivirus 1.2 Mb genome is elegantly organized into a 30 nm diameter helical protein shield. Elife, 11, 2022
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7YX4
| Structure of the Mimivirus genomic fibre in its compact 5-start helix form | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Putative glucose-methanol-choline oxidoreductase protein | Authors: | Villalta, A, Schmitt, A, Estrozi, L.F, Quemin, E.R.J, Alempic, J.M, Lartigue, A, Prazak, V, Belmudes, L, Vasishtan, D, Colmant, A.M.G, Honore, F.A, Coute, Y, Grunewald, K, Abergel, C. | Deposit date: | 2022-02-15 | Release date: | 2022-08-10 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | The giant mimivirus 1.2 Mb genome is elegantly organized into a 30 nm diameter helical protein shield. Elife, 11, 2022
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7YX3
| Structure of the Mimivirus genomic fibre in its compact 6-start helix form | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Putative GMC-type oxidoreductase | Authors: | Villalta, A, Schmitt, A, Estrozi, L.F, Quemin, E.R.J, Alempic, J.M, Lartigue, A, Prazak, V, Belmudes, L, Vasishtan, D, Colmant, A.M.G, Honore, F.A, Coute, Y, Grunewald, K, Abergel, C. | Deposit date: | 2022-02-15 | Release date: | 2022-08-10 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | The giant mimivirus 1.2 Mb genome is elegantly organized into a 30-nm diameter helical protein shield. Elife, 11, 2022
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4WD4
| Crystal structure of human HO1 H25R | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Caaveiro, J.M.M, Morante, K, Sigala, P, Tsumoto, K. | Deposit date: | 2014-09-06 | Release date: | 2015-09-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | In-Cell Enzymology To Probe His-Heme Ligation in Heme Oxygenase Catalysis Biochemistry, 55, 2016
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1QG3
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1QHQ
| AURACYANIN, A BLUE COPPER PROTEIN FROM THE GREEN THERMOPHILIC PHOTOSYNTHETIC BACTERIUM CHLOROFLEXUS AURANTIACUS | Descriptor: | CHLORIDE ION, COPPER (II) ION, PROTEIN (AURACYANIN), ... | Authors: | Bond, C.S, Blankenship, R.E, Freeman, H.C, Guss, J.M, Maher, M, Selvaraj, F, Wilce, M.C.J, Willingham, K. | Deposit date: | 1999-05-25 | Release date: | 2001-03-07 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal structure of auracyanin, a "blue" copper protein from the green thermophilic photosynthetic bacterium Chloroflexus aurantiacus. J.Mol.Biol., 306, 2001
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1R0O
| Crystal Structure of the Heterodimeric Ecdysone Receptor DNA-binding Complex | Descriptor: | Ecdysone Response Element, Ecdysone receptor, Ultraspiracle protein, ... | Authors: | Devarakonda, S, Harp, J.M, Kim, Y, Ozyhar, A, Rastinejad, F. | Deposit date: | 2003-09-22 | Release date: | 2003-10-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Structure of the Heterodimeric Ecdysone Receptor DNA-binding Complex Embo J., 22, 2003
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1QRH
| X-RAY STRUCTURE OF THE DNA-ECO RI ENDONUCLEASE COMPLEXES WITH AN R145K MUTATION AT 2.7 A | Descriptor: | 5'-(TP*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G*)-3', ECO RI ENDONCULEASE | Authors: | Choi, J, Kim, Y, Greene, P, Hager, P, Rosenberg, J.M. | Deposit date: | 1999-06-14 | Release date: | 1999-06-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | X-Ray Structure of the DNA-Eco RI Endonuclease Complexes with the ED144 and RK145 Mutations To be Published
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1QRQ
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1QCO
| CRYSTAL STRUCTURE OF FUMARYLACETOACETATE HYDROLASE COMPLEXED WITH FUMARATE AND ACETOACETATE | Descriptor: | ACETOACETIC ACID, CALCIUM ION, FUMARIC ACID, ... | Authors: | Timm, D.E, Mueller, H.A, Bhanumoorthy, P, Harp, J.M, Bunick, G.J. | Deposit date: | 1999-05-17 | Release date: | 2000-06-07 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure and mechanism of a carbon-carbon bond hydrolase. Structure Fold.Des., 7, 1999
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1QPS
| THE CRYSTAL STRUCTURE OF A POST-REACTIVE COGNATE DNA-ECO RI COMPLEX AT 2.50 A IN THE PRESENCE OF MN2+ ION | Descriptor: | 5'-D(*AP*AP*TP*TP*CP*GP*CP*GP*)-3', 5'-D(*TP*CP*GP*CP*GP*)-3', ENDONUCLEASE ECORI, ... | Authors: | Horvath, M, Choi, J, Kim, Y, Wilkosz, P, Rosenberg, J.M. | Deposit date: | 1999-05-28 | Release date: | 1999-06-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The Integration of Recognition and Cleavage: X-Ray Structures of Pre- Transition State and Post-Reactive DNA-Eco RI Endonuclease Complexes To be Published
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1Q9P
| Solution structure of the mature HIV-1 protease monomer | Descriptor: | HIV-1 Protease | Authors: | Ishima, R, Torchia, D.A, Lynch, S.M, Gronenborn, A.M, Louis, J.M. | Deposit date: | 2003-08-25 | Release date: | 2004-03-02 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of the mature HIV-1 protease monomer: Insight into the tertiary fold and stability of a precursor J.Biol.Chem., 278, 2003
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1Q7S
| Crystal structure of bit1 | Descriptor: | bit1 | Authors: | De Pereda, J.M, Waas, W.F, Jan, Y, Ruoslahti, E, Schimmel, P, Pascual, J. | Deposit date: | 2003-08-19 | Release date: | 2003-12-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity. J.Biol.Chem., 279, 2004
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1QKR
| Crystal structure of the vinculin tail and a pathway for activation | Descriptor: | SULFATE ION, VINCULIN | Authors: | Bakolitsa, C, De Pereda, J.M, Bagshaw, C.R, Critchley, D.R, Liddington, R.C. | Deposit date: | 1999-08-04 | Release date: | 2000-08-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of the Vinculin Tail and a Pathway for Activation Cell(Cambridge,Mass.), 99, 1999
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1QZR
| CRYSTAL STRUCTURE OF THE ATPASE REGION OF SACCHAROMYCES CEREVISIAE TOPOISOMERASE II BOUND TO ICRF-187 (DEXRAZOXANE) | Descriptor: | (S)-4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS-2,6-PIPERAZINEDIONE, DNA topoisomerase II, MAGNESIUM ION, ... | Authors: | Classen, S, Olland, S, Berger, J.M. | Deposit date: | 2003-09-17 | Release date: | 2003-09-30 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187 Proc.Natl.Acad.Sci.USA, 100, 2003
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1QXK
| Monoacid-Based, Cell Permeable, Selective Inhibitors of Protein Tyrosine Phosphatase 1B | Descriptor: | 2-{4-[2-ACETYLAMINO-3-(4-CARBOXYMETHOXY-3-HYDROXY-PHENYL)-PROPIONYLAMINO]-BUTOXY}-6-HYDROXY-BENZOIC ACID METHYL ESTER, Protein-tyrosine phosphatase, non-receptor type 1 | Authors: | Xin, Z, Liu, G, Abad-Zapatero, C, Pei, Z, Szczepankiewick, B.G, Li, X, Zhang, T, Hutchins, C.W, Hajduk, P.J, Ballaron, S.J, Stashko, M.A, Lubben, T.H, Trevillyan, J.M, Jirousek, M.R. | Deposit date: | 2003-09-08 | Release date: | 2003-10-28 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Identification of a Monoacid-Based, Cell Permeable, Selective
Inhibitor of Protein Tyrosine Phosphatase 1B BIOORG.MED.CHEM.LETT., 13, 2003
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1R03
| crystal structure of a human mitochondrial ferritin | Descriptor: | MAGNESIUM ION, mitochondrial ferritin | Authors: | Corsi, B, Santambrogio, P, Arosio, P, Levi, S, Langlois d'Estaintot, B, Granier, T, Gallois, B, Chevallier, J.M, Precigoux, G. | Deposit date: | 2003-09-19 | Release date: | 2004-06-29 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal Structure and Biochemical Properties of the Human Mitochondrial Ferritin and its Mutant Ser144Ala J.Mol.Biol., 340, 2004
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1R0G
| mercury-substituted rubredoxin | Descriptor: | MERCURY (II) ION, Rubredoxin | Authors: | Maher, M, Cross, M, Wilce, M.C.J, Guss, J.M, Wedd, A.G. | Deposit date: | 2003-09-22 | Release date: | 2004-02-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Metal-substituted derivatives of the rubredoxin from Clostridium pasteurianum. Acta Crystallogr.,Sect.D, 60, 2004
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1R0I
| cadmium-substituted rubredoxin | Descriptor: | CADMIUM ION, Rubredoxin | Authors: | Maher, M, Cross, M, Wilce, M.C.J, Guss, J.M, Wedd, A.G. | Deposit date: | 2003-09-22 | Release date: | 2004-02-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Metal-substituted derivatives of the rubredoxin from Clostridium pasteurianum. Acta Crystallogr.,Sect.D, 60, 2004
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1R0J
| nickel-substituted rubredoxin | Descriptor: | NICKEL (II) ION, Rubredoxin | Authors: | Maher, M, Cross, M, Wilce, M.C.J, Guss, J.M, Wedd, A.G. | Deposit date: | 2003-09-22 | Release date: | 2004-02-10 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Metal-substituted derivatives of the rubredoxin from Clostridium pasteurianum. Acta Crystallogr.,Sect.D, 60, 2004
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