1QZR
CRYSTAL STRUCTURE OF THE ATPASE REGION OF SACCHAROMYCES CEREVISIAE TOPOISOMERASE II BOUND TO ICRF-187 (DEXRAZOXANE)
Replaces: 1Q1DSummary for 1QZR
Entry DOI | 10.2210/pdb1qzr/pdb |
Related | 1BGW 1BJT 1PVG |
Descriptor | DNA topoisomerase II, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total) |
Functional Keywords | ghkl atpase domain, icrf, icrf-187, dexrazoxane, isomerase |
Biological source | Saccharomyces cerevisiae (baker's yeast) |
Cellular location | Nucleus: P06786 |
Total number of polymer chains | 2 |
Total formula weight | 97527.15 |
Authors | Classen, S.,Olland, S.,Berger, J.M. (deposition date: 2003-09-17, release date: 2003-09-30, Last modification date: 2023-08-23) |
Primary citation | Classen, S.,Olland, S.,Berger, J.M. Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187 Proc.Natl.Acad.Sci.USA, 100:10629-10634, 2003 Cited by PubMed: 12963818DOI: 10.1073/pnas.1832879100 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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