1QZR
CRYSTAL STRUCTURE OF THE ATPASE REGION OF SACCHAROMYCES CEREVISIAE TOPOISOMERASE II BOUND TO ICRF-187 (DEXRAZOXANE)
Replaces: 1Q1DEntity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DNA topoisomerase II | polymer | 418 | 48098.9 | 2 | UniProt (P06786) Pfam (PF02518) Pfam (PF00204) | Saccharomyces cerevisiae (baker's yeast) | |
| 2 | C, E (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D, G (A, B) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
| 4 | F (B) | (S)-4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS-2,6-PIPERAZINEDIONE | non-polymer | 268.3 | 1 | Chemie (CDX) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 766 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 413 (UniProt: P06786)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | cloning artifact |
| His -3 | - | cloning artifact |
| Met -2 | - | cloning artifact |
| Val -1 | - | cloning artifact |
| Thr 0 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 96197.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1329.3 | |
| All* | Total formula weight | 97527.1 |
