1QXK

Monoacid-Based, Cell Permeable, Selective Inhibitors of Protein Tyrosine Phosphatase 1B

Summary for 1QXK
Related1NL9 1NNY 1NO6 1NZ7 1ONY 1PHO
DescriptorProtein-tyrosine phosphatase, non-receptor type 1, 2-{4-[2-ACETYLAMINO-3-(4-CARBOXYMETHOXY-3-HYDROXY-PHENYL)-PROPIONYLAMINO]-BUTOXY}-6-HYDROXY-BENZOIC ACID METHYL ESTER (3 entities in total)
Functional Keywordsprotein tyrosine phosphatase 1b, ptp1b monoacid-based and cell permeable, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
Total number of polymer chains1
Total formula weight37884.15
Authors
Primary citationAbad-Zapatero, C.,Ballaron, S.J.,Hajduk, P.J.,Hutchins, C.W.,Jirousek, M.R.,Li, X.,Liu, G.,Lubben, T.H.,Pei, Z.,Stashko, M.A.,Szczepankiewick, B.G.,Trevillyan, J.M.,Xin, Z.,Zhang, T.
Identification of a Monoacid-Based, Cell Permeable, Selective Inhibitor of Protein Tyrosine Phosphatase 1B
BIOORG.MED.CHEM.LETT., 13:3947-3950, 2003
PubMed: 14592481
DOI: 110.1016/j.bmcl.2003.08.064
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation
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PDB entries from 2021-06-16