Monoacid-Based, Cell Permeable, Selective Inhibitors of Protein Tyrosine Phosphatase 1B

Summary for 1QXK

Related1NL9 1NNY 1NO6 1NZ7 1ONY 1PHO
DescriptorProtein-tyrosine phosphatase, non-receptor type 1, 2-{4-[2-ACETYLAMINO-3-(4-CARBOXYMETHOXY-3-HYDROXY-PHENYL)-PROPIONYLAMINO]-BUTOXY}-6-HYDROXY-BENZOIC ACID METHYL ESTER (3 entities in total)
Functional Keywordsprotein tyrosine phosphatase 1b, ptp1b monoacid-based and cell permeable, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side  P18031
Total number of polymer chains1
Total molecular weight37884.15
Primary citation
Xin, Z.,Liu, G.,Abad-Zapatero, C.,Pei, Z.,Szczepankiewick, B.G.,Li, X.,Zhang, T.,Hutchins, C.W.,Hajduk, P.J.,Ballaron, S.J.,Stashko, M.A.,Lubben, T.H.,Trevillyan, J.M.,Jirousek, M.R.
Identification of a Monoacid-Based, Cell Permeable, Selective Inhibitor of Protein Tyrosine Phosphatase 1B
BIOORG.MED.CHEM.LETT., 13:3947-3950, 2003
PubMed: 14592481 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2003.08.064
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers190.7%3.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload