1NZ7

POTENT, SELECTIVE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B USING A SECOND PHOSPHOTYROSINE BINDING SITE, complexed with compound 19.

Summary for 1NZ7

Entry DOI	10.2210/pdb1nz7/pdb
Related	1NL9 1NNY 1No6 1ONY 1ONZ
Descriptor	Protein-tyrosine phosphatase, non-receptor type 1, 2-[(4-{2-ACETYLAMINO-2-[4-(1-CARBOXY-3-METHYLSULFANYL-PROPYLCARBAMOYL)-BUTYLCARBAMOYL]-ETHYL}-2-ETHYL-PHENYL)-OXALYL-AM INO]-BENZOIC ACID (3 entities in total)
Functional Keywords	protein tyrosine phosphatase fold, oxamic acid inhibitor bound to p-loop, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
Total number of polymer chains	1
Total formula weight	38038.38
Authors	Xin, Z.,Oost, T.K.,Abad-Zapatero, C.,Hajduk, P.J.,Pei, Z.,Szczepankiewicz, B.G.,Hutchins, C.W.,Ballaron, S.J.,Stashko, M.A.,Lubben, T.,Trevillyan, J.M.,Jirousek, M.R.,Liu, G. (deposition date: 2003-02-16, release date: 2003-05-20, Last modification date: 2023-08-16)
Primary citation	Xin, Z.,Oost, T.K.,Abad-Zapatero, C.,Hajduk, P.J.,Pei, Z.,Szczepankiewicz, B.G.,Hutchins, C.W.,Ballaron, S.J.,Stashko, M.A.,Lubben, T.,Trevillyan, J.M.,Jirousek, M.R.,Liu, G. Potent, Selective Inhibitors of Protein Tyrosine Phosphatase 1B BIOORG.MED.CHEM.LETT., 13:1887-1890, 2003 Cited by PubMed: 12749891 DOI: 10.1016/S0960-894X(03)00302-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation