5MCB
 
 | | Glycogen phosphorylase in complex with chlorogenic acid. | | Descriptor: | Chlorogenic acid, Glycogen phosphorylase, muscle form, ... | | Authors: | Leonidas, D.D, Stravodimos, G.A, Kyriakis, E, Chatzileontiadou, D.S.M, Kantsadi, A.L. | | Deposit date: | 2016-11-09 | | Release date: | 2017-09-20 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Affinity Crystallography Reveals the Bioactive Compounds of Industrial Juicing Byproducts of Punica granatum for Glycogen Phosphorylase.
Curr Drug Discov Technol, 15, 2018
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5MWG
 | | Crystal structure of the human BRPF1 bromodomain in complex with BZ091 | | Descriptor: | NITRATE ION, Peregrin, ~{N}-[1,4-dimethyl-2,3-bis(oxidanylidene)-7-piperidin-1-yl-quinoxalin-6-yl]-5,6,7,8-tetrahydronaphthalene-2-sulfonamide | | Authors: | Zhu, J, Caflisch, A. | | Deposit date: | 2017-01-18 | | Release date: | 2018-02-14 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structure-based discovery of selective BRPF1 bromodomain inhibitors.
Eur J Med Chem, 155, 2018
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5MWH
 | | Crystal structure of the human BRPF1 bromodomain in complex with BZ089 | | Descriptor: | NITRATE ION, Peregrin, ~{N}-[1,4-dimethyl-7-morpholin-4-yl-2,3-bis(oxidanylidene)quinoxalin-6-yl]-4-(2-methylpropyl)benzenesulfonamide | | Authors: | Zhu, J, Caflisch, A. | | Deposit date: | 2017-01-18 | | Release date: | 2018-02-14 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structure-based discovery of selective BRPF1 bromodomain inhibitors.
Eur J Med Chem, 155, 2018
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5MWZ
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5N22
 | | Structure of xEco2 acetyltransferase domain bound to K106-CoA conjugate | | Descriptor: | (2~{S})-2-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]propanoic acid, GLY-ALA-LYS-LYX-ASP-GLN-TYR-PHE-LEU, XEco2 | | Authors: | Chao, W.C.H, Wade, B.O, Singleton, M.R. | | Deposit date: | 2017-02-07 | | Release date: | 2017-03-15 | | Last modified: | 2017-09-13 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Structural Basis of Eco1-Mediated Cohesin Acetylation.
Sci Rep, 7, 2017
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5N1W
 | | Structure of xEco2 acetyltransferase domain bound to K105-CoA conjugate | | Descriptor: | (2~{S})-2-[2-[3-[[(2~{R})-4-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethylsulfanyl]propanoic acid, ILE-GLY-ALA-LYX-LYS-ALA,ILE-GLY-ALA-LYX-LYS-ALA,ILE-GLY-ALA-LYX-LYS-ALA,ILE-GLY-ALA-LYX-LYS-ALA, MAGNESIUM ION, ... | | Authors: | Chao, W.C.H, Wade, B.O, Singleton, M.R. | | Deposit date: | 2017-02-06 | | Release date: | 2017-03-15 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Basis of Eco1-Mediated Cohesin Acetylation.
Sci Rep, 7, 2017
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5N1U
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5XQX
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5XS2
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5JCB
 | | Microtubule depolymerizing agent podophyllotoxin derivative YJTSF1 | | Descriptor: | (5R,5aR,8aS,9R)-9-[(4H-1,2,4-triazol-3-yl)sulfanyl]-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydro-2H-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | | Authors: | Guan, Z, Zhao, W, Yin, P. | | Deposit date: | 2016-04-14 | | Release date: | 2017-09-27 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Insights into the Inhibition of Tubulin by the Antitumor Agent 4 beta-(1,2,4-triazol-3-ylthio)-4-deoxypodophyllotoxin.
ACS Chem. Biol., 12, 2017
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7JY7
 | | Structure of a 12 base pair RecA-D loop complex | | Descriptor: | DNA (27-MER), DNA (48-MER), MAGNESIUM ION, ... | | Authors: | Pavletich, N.P. | | Deposit date: | 2020-08-29 | | Release date: | 2020-11-04 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Mechanism of strand exchange from RecA-DNA synaptic and D-loop structures.
Nature, 586, 2020
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4R5Y
 | | The complex structure of Braf V600E kinase domain with a novel Braf inhibitor | | Descriptor: | 5-({(1R,1aS,6bR)-1-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one, Serine/threonine-protein kinase B-raf | | Authors: | Feng, Y, Peng, H, Zhang, Y, Liu, Y, Wei, M. | | Deposit date: | 2014-08-22 | | Release date: | 2016-02-24 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers.
Mol.Cancer Ther., 14, 2015
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7JY9
 | | Structure of a 9 base pair RecA-D loop complex | | Descriptor: | DNA (27-MER), DNA (42-MER), MAGNESIUM ION, ... | | Authors: | Pavletich, N.P. | | Deposit date: | 2020-08-29 | | Release date: | 2020-11-04 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Mechanism of strand exchange from RecA-DNA synaptic and D-loop structures.
Nature, 586, 2020
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7JY6
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7JY8
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8CVT
 | | Human 19S-20S proteasome, state SD2 | | Descriptor: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 8, 26S proteasome complex subunit SEM1, ... | | Authors: | Zhao, J. | | Deposit date: | 2022-05-18 | | Release date: | 2022-11-02 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8CVR
 | | Human 20S proteasome with MG-132 | | Descriptor: | N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]-L-leucinamide, Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, ... | | Authors: | Zhao, J. | | Deposit date: | 2022-05-18 | | Release date: | 2022-11-02 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8CVS
 | | Human PA200-20S proteasome with MG-132 | | Descriptor: | INOSITOL HEXAKISPHOSPHATE, N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-4-methyl-1-oxopentan-2-yl]-L-leucinamide, Proteasome activator complex subunit 4, ... | | Authors: | Zhao, J. | | Deposit date: | 2022-05-18 | | Release date: | 2022-11-02 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8CXB
 | | Human PA28-20S (PA28-4a3b) | | Descriptor: | Proteasome activator complex subunit 1, Proteasome activator complex subunit 2, Proteasome subunit alpha type-1, ... | | Authors: | Zhao, J, Makhija, S, Huang, B, Cheng, Y. | | Deposit date: | 2022-05-20 | | Release date: | 2022-11-02 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8DL5
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5KJ2
 | | The novel p300/CBP inhibitor A-485 uncovers a unique mechanism of action to target AR in castrate resistant prostate cancer | | Descriptor: | Histone acetyltransferase p300, N-[(4-fluorophenyl)methyl]-2-{(1R)-5-[(methylcarbamoyl)amino]-2',4'-dioxo-2,3-dihydro-3'H-spiro[indene-1,5'-[1,3]oxazolidin]-3'-yl}-N-[(2S)-1,1,1-trifluoropropan-2-yl]acetamide, SODIUM ION | | Authors: | Jakob, C.G, Qiu, W, Edalji, R.P, Sun, C. | | Deposit date: | 2016-06-17 | | Release date: | 2017-09-27 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.
Nature, 550, 2017
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4H18
 | | Three dimensional structure of corynomycoloyl tranferase C | | Descriptor: | Cmt1, MAGNESIUM ION | | Authors: | Huc, E, de Sousa D'Auria, C, Li de la Sierra-Gallay, I, Salmeron, C.H, van Tilbeurgh, H, Bayan, N, Houssin, C.H, Daffe, M, Tropis, M. | | Deposit date: | 2012-09-10 | | Release date: | 2013-09-25 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.755 Å) | | Cite: | Identification of a mycoloyl transferase selectively involved in o-acylation of polypeptides in corynebacteriales.
J.Bacteriol., 195, 2013
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8GMU
 | | Structure of lambda repressor in complex with RecA filament | | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*T)-3'), MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | Authors: | Gao, B, Feng, Y. | | Deposit date: | 2022-08-22 | | Release date: | 2022-12-21 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (2.78 Å) | | Cite: | Structural basis for regulation of SOS response in bacteria.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8GMT
 | | Structure of UmuD in complex with RecA filament | | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*T)-3'), DNA polymerase V subunit UmuD, MAGNESIUM ION, ... | | Authors: | Gao, B, Feng, Y. | | Deposit date: | 2022-08-22 | | Release date: | 2022-12-21 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.31 Å) | | Cite: | Structural basis for regulation of SOS response in bacteria.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8GMS
 | | Structure of LexA in complex with RecA filament | | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*T)-3'), LexA repressor, MAGNESIUM ION, ... | | Authors: | Gao, B, Feng, Y. | | Deposit date: | 2022-08-22 | | Release date: | 2022-12-21 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.31 Å) | | Cite: | Structural basis for regulation of SOS response in bacteria.
Proc.Natl.Acad.Sci.USA, 120, 2023
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