8I3B
 
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8I3C
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8I38
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8I3A
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6KAG
 | | Crystal structure of the SMARCB1/SMARCC2 subcomplex | | Descriptor: | SWI/SNF complex subunit SMARCC2, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 | | Authors: | Chen, G, Zhou, H, Giancotti, F.G, Long, J. | | Deposit date: | 2019-06-22 | | Release date: | 2020-09-23 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.601 Å) | | Cite: | A heterotrimeric SMARCB1-SMARCC2 subcomplex is required for the assembly and tumor suppression function of the BAF chromatin-remodeling complex.
Cell Discov, 6, 2020
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6LB8
 | | Crystal structure of the Ca2+-free T4L-MICU1-MICU2 complex | | Descriptor: | Calcium uptake protein 2, mitochondrial, Endolysin,Calcium uptake protein 1 | | Authors: | Wu, W, Shen, Q, Zheng, J, Jia, Z. | | Deposit date: | 2019-11-13 | | Release date: | 2020-07-15 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.283 Å) | | Cite: | The structure of the MICU1-MICU2 complex unveils the regulation of the mitochondrial calcium uniporter.
Embo J., 39, 2020
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7DMP
 | | Mouse radial spoke complex | | Descriptor: | Radial spoke head 1 homolog, Radial spoke head protein 4 homolog A, Radial spoke head protein 9 homolog | | Authors: | Zheng, W, Cong, Y. | | Deposit date: | 2020-12-05 | | Release date: | 2021-07-21 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM
Proc.Natl.Acad.Sci.USA, 118, 2021
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6LB7
 | | Crystal structure of the Ca2+-free and Ca2+-bound MICU1-MICU2 complex | | Descriptor: | CALCIUM ION, Calcium uptake protein 1, mitochondrial, ... | | Authors: | Wu, W, Shen, Q, Zheng, J, Jia, Z. | | Deposit date: | 2019-11-13 | | Release date: | 2020-07-15 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.101 Å) | | Cite: | The structure of the MICU1-MICU2 complex unveils the regulation of the mitochondrial calcium uniporter.
Embo J., 39, 2020
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6M8Q
 | | Cleavage and Polyadenylation Specificity Factor Subunit 3 (CPSF3) in complex with NVP-LTM531 | | Descriptor: | Cleavage and polyadenylation specificity factor subunit 3, N-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzene-1-carbonyl}-L-phenylalanine, PHOSPHATE ION, ... | | Authors: | Weihofen, W.A, Salcius, M, Michaud, G. | | Deposit date: | 2018-08-22 | | Release date: | 2019-11-27 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.49 Å) | | Cite: | CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma.
Nat.Chem.Biol., 16, 2020
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6M1K
 | | USP7 in complex with a novel inhibitor | | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 7, methyl 4-[[4-[[3-[4-(aminomethyl)phenyl]-2-methyl-7-oxidanylidene-pyrazolo[4,3-d]pyrimidin-6-yl]methyl]-4-oxidanyl-piperidin-1-yl]methyl]-3-chloranyl-benzoate | | Authors: | Liu, S.J, Zhou, X.Y, Li, M.L, Sun, H.B, Wen, X.A. | | Deposit date: | 2020-02-26 | | Release date: | 2021-03-10 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.255 Å) | | Cite: | N-benzylpiperidinol derivatives as novel USP7 inhibitors: Structure-activity relationships and X-ray crystallographic studies.
Eur.J.Med.Chem., 199, 2020
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7F3N
 | | Structure of PopP2 in apo form | | Descriptor: | Type III effector protein popp2 | | Authors: | Xia, Y, Zhang, Z.M. | | Deposit date: | 2021-06-16 | | Release date: | 2021-11-17 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.351856 Å) | | Cite: | Secondary-structure switch regulates the substrate binding of a YopJ family acetyltransferase.
Nat Commun, 12, 2021
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1CF5
 | | BETA-MOMORCHARIN STRUCTURE AT 2.55 A | | Descriptor: | PROTEIN (BETA-MOMORCHARIN), beta-D-xylopyranose-(1-2)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Yuan, Y.-R, He, Y.-N, Xiong, J.-P, Xia, Z.-X. | | Deposit date: | 1999-03-24 | | Release date: | 1999-06-07 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Three-dimensional structure of beta-momorcharin at 2.55 A resolution.
Acta Crystallogr.,Sect.D, 55, 1999
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6NNJ
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6NAX
 | | Olfactomedin domain of mouse myocilin | | Descriptor: | CALCIUM ION, GLYCEROL, Myocilin, ... | | Authors: | Patterson-Orazem, A.C, Hill, S.E, Lieberman, R.L. | | Deposit date: | 2018-12-06 | | Release date: | 2019-03-13 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.551 Å) | | Cite: | Differential Misfolding Properties of Glaucoma-Associated Olfactomedin Domains from Humans and Mice.
Biochemistry, 58, 2019
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6LQE
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6LQF
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6NNF
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6NWL
 | | Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with hydrocortisone and PGC1a coregulator fragment | | Descriptor: | (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ... | | Authors: | Liu, X, Ortlund, E.A. | | Deposit date: | 2019-02-06 | | Release date: | 2019-10-23 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.595 Å) | | Cite: | First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain-Peroxisome Proliferator-ActivatedgammaCoactivator 1-alphaComplex with Endogenous and Synthetic Glucocorticoids.
Mol.Pharmacol., 96, 2019
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6NM6
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6MWE
 | | CRYSTAL STRUCTURE OF TIE2 IN COMPLEX WITH DECIPERA COMPOUND DP1919 | | Descriptor: | 4-[4-({[3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide, Angiopoietin-1 receptor, SULFATE ION | | Authors: | Chun, L, Abendroth, J, Edwards, T.E. | | Deposit date: | 2018-10-29 | | Release date: | 2018-11-21 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2
Mol. Cancer Ther., 16, 2017
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7YF7
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6NWK
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7E9B
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7WSW
 | | Cryo-EM structure of the Potassium channel AKT1 from Arabidopsis thaliana | | Descriptor: | PHOSPHATIDYLETHANOLAMINE, POTASSIUM ION, Potassium channel AKT1 | | Authors: | Yang, G.H, Lu, Y.M, Zhang, Y.M, Jia, Y.T, Li, X.M, Lei, J.L. | | Deposit date: | 2022-02-02 | | Release date: | 2022-11-09 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural basis for the activity regulation of a potassium channel AKT1 from Arabidopsis.
Nat Commun, 13, 2022
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7EYO
 | | Crystal structure of leech hyaluronidase | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Hyaluronoglucuronidase | | Authors: | Huang, H, Hou, X.D, Rao, Y.J, Kang, Z. | | Deposit date: | 2021-05-31 | | Release date: | 2022-05-25 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structure and cleavage pattern of a hyaluronate 3-glycanohydrolase in the glycoside hydrolase 79 family.
Carbohydr Polym, 277, 2022
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