6M8Q

Cleavage and Polyadenylation Specificity Factor Subunit 3 (CPSF3) in complex with NVP-LTM531

Summary for 6M8Q

• Entry DOI: 10.2210/pdb6m8q/pdb
• Descriptor: Cleavage and polyadenylation specificity factor subunit 3, ZINC ION, N-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzene-1-carbonyl}-L-phenylalanine, ... (5 entities in total)
• Functional Keywords: polyadenylation, metallo-b-lactamase, pre-mrna processing, artemis, v(d)j recombination, double-strand break repair, hydrolase, rna binding protein, hydroxylase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 110225.46

Authors

Weihofen, W.A.,Salcius, M.,Michaud, G. (deposition date: 2018-08-22, release date: 2019-11-27, Last modification date: 2023-10-11)

• Primary citation: Ross, N.T.,Lohmann, F.,Carbonneau, S.,Fazal, A.,Weihofen, W.A.,Gleim, S.,Salcius, M.,Sigoillot, F.,Henault, M.,Carl, S.H.,Rodriguez-Molina, J.B.,Miller, H.R.,Brittain, S.M.,Murphy, J.,Zambrowski, M.,Boynton, G.,Wang, Y.,Chen, A.,Molind, G.J.,Wilbertz, J.H.,Artus-Revel, C.G.,Jia, M.,Akinjiyan, F.A.,Turner, J.,Knehr, J.,Carbone, W.,Schuierer, S.,Reece-Hoyes, J.S.,Xie, K.,Saran, C.,Williams, E.T.,Roma, G.,Spencer, M.,Jenkins, J.,George, E.L.,Thomas, J.R.,Michaud, G.,Schirle, M.,Tallarico, J.,Passmore, L.A.,Chao, J.A.,Beckwith, R.E.J.; CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma.; Nat.Chem.Biol., 16:50-59, 2020; PubMed: 31819276; DOI: 10.1038/s41589-019-0424-1

Experimental method

X-RAY DIFFRACTION (2.49 Å)