6M8Q
Cleavage and Polyadenylation Specificity Factor Subunit 3 (CPSF3) in complex with NVP-LTM531
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | ASP75 |
| A | HIS76 |
| A | ASP179 |
| A | HIS418 |
| A | ZN502 |
| A | PO4505 |
| A | HOH630 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue ZN A 502 |
| Chain | Residue |
| A | HIS158 |
| A | ASP179 |
| A | ZN501 |
| A | PO4505 |
| A | HOH630 |
| A | HIS71 |
| A | HIS73 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | binding site for residue JBG A 503 |
| Chain | Residue |
| A | ILE43 |
| A | HIS44 |
| A | PRO45 |
| A | LEU47 |
| A | GLU48 |
| A | ALA52 |
| A | TYR110 |
| A | PRO239 |
| A | VAL240 |
| A | PHE241 |
| A | PRO329 |
| A | GLY330 |
| A | MET331 |
| A | GLN333 |
| A | GLY356 |
| A | HOH637 |
| A | HOH647 |
| A | HOH663 |
| A | HOH672 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 504 |
| Chain | Residue |
| A | TYR207 |
| A | HIS212 |
| A | GLU213 |
| A | ARG218 |
| A | SER392 |
| A | HOH714 |
| B | ARG426 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for residue PO4 A 505 |
| Chain | Residue |
| A | HIS73 |
| A | ASP75 |
| A | HIS158 |
| A | ASP179 |
| A | TYR357 |
| A | HIS396 |
| A | HIS418 |
| A | ZN501 |
| A | ZN502 |
| A | HOH608 |
| A | HOH630 |
| A | HOH671 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue ZN B 501 |
| Chain | Residue |
| B | ASP75 |
| B | HIS76 |
| B | ASP179 |
| B | HIS418 |
| B | ZN502 |
| B | PO4504 |
| B | HOH603 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue ZN B 502 |
| Chain | Residue |
| B | HIS71 |
| B | HIS73 |
| B | HIS158 |
| B | ASP179 |
| B | ZN501 |
| B | PO4504 |
| B | HOH603 |
| site_id | AC8 |
| Number of Residues | 17 |
| Details | binding site for residue JBG B 503 |
| Chain | Residue |
| B | ILE43 |
| B | HIS44 |
| B | PRO45 |
| B | LEU47 |
| B | LEU74 |
| B | TYR110 |
| B | SER114 |
| B | PRO239 |
| B | VAL240 |
| B | PHE241 |
| B | PRO329 |
| B | GLY330 |
| B | MET331 |
| B | GLY356 |
| B | HOH637 |
| B | HOH641 |
| B | HOH683 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | binding site for residue PO4 B 504 |
| Chain | Residue |
| B | HIS73 |
| B | ASP75 |
| B | HIS158 |
| B | ASP179 |
| B | TYR357 |
| B | SER394 |
| B | HIS396 |
| B | HIS418 |
| B | ZN501 |
| B | ZN502 |
| B | HOH603 |
| B | HOH618 |
| B | HOH674 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17128255","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2I7T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I7V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
