6M8Q

Cleavage and Polyadenylation Specificity Factor Subunit 3 (CPSF3) in complex with NVP-LTM531

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Cleavage and polyadenylation specificity factor subunit 3	polymer	478	54343.1	2	UniProt (Q9UKF6) Pfam (PF00753) Pfam (PF10996) Pfam (PF07521)	Homo sapiens (Human)	Cleavage and polyadenylation specificity factor 73 kDa subunit,CPSF 73 kDa subunit,mRNA 3'-end-processing endonuclease CPSF-73
2	C, D, H, I (A, B)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
3	E, J (A, B)	N-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzene-1-carbonyl}-L-phenylalanine	non-polymer		496.4	2	Chemie (JBG)
4	F, G, K (A, B)	PHOSPHATE ION	non-polymer		95.0	3	Chemie (PO4)
5	L, M (A, B)	water	water		18.0	484	Chemie (HOH)

Sequence modifications

A, B: 1 - 459 (UniProt: Q9UKF6)

PDB	External Database	Details
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	108686.1
Non-Polymers*	Number of molecules	9
	Total formula weight	1539.3
All*	Total formula weight	110225.5

*Water molecules are not included.