1PWO
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![BU of 1pwo by Molmil](/molmil-images/mine/1pwo) | |
3LPK
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![BU of 3lpk by Molmil](/molmil-images/mine/3lpk) | Structure of BACE Bound to SCH747123 | Descriptor: | Beta-secretase 1, L(+)-TARTARIC ACID, N-[(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-2-{(2R)-4-[(3-methylphenyl)sulfonyl]piperazin-2-yl}ethyl]-3-{[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]carbonyl}-5-methylbenzamide | Authors: | Strickland, C, Cumming, J. | Deposit date: | 2010-02-05 | Release date: | 2010-04-14 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization. Bioorg.Med.Chem.Lett., 20, 2010
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3LNK
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![BU of 3lnk by Molmil](/molmil-images/mine/3lnk) | Structure of BACE bound to SCH743813 | Descriptor: | Beta-secretase 1, L(+)-TARTARIC ACID, N'-{(1S,2S)-1-(3,5-difluorobenzyl)-2-hydroxy-2-[(2R)-4-(phenylcarbonyl)piperazin-2-yl]ethyl}-5-methyl-N,N-dipropylbenzene-1,3-dicarboxamide | Authors: | Orth, P, Cumming, J. | Deposit date: | 2010-02-02 | Release date: | 2010-04-14 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization. Bioorg.Med.Chem.Lett., 20, 2010
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8FY9
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![BU of 8fy9 by Molmil](/molmil-images/mine/8fy9) | Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-deficient prespacer complex | Descriptor: | Cas1, Cas2-DEDDh, DNA (28-MER) | Authors: | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | Deposit date: | 2023-01-25 | Release date: | 2023-05-03 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Genome expansion by a CRISPR trimmer-integrase. Nature, 618, 2023
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8FYB
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![BU of 8fyb by Molmil](/molmil-images/mine/8fyb) | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex | Descriptor: | Cas1, Cas2-DEDDh, DNA (17-MER), ... | Authors: | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | Deposit date: | 2023-01-25 | Release date: | 2023-05-03 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Genome expansion by a CRISPR trimmer-integrase. Nature, 618, 2023
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8FYC
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![BU of 8fyc by Molmil](/molmil-images/mine/8fyc) | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex linear CRISPR repeat conformation | Descriptor: | Cas1, Cas2-DEDDh, DEDDh, ... | Authors: | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | Deposit date: | 2023-01-25 | Release date: | 2023-05-03 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Genome expansion by a CRISPR trimmer-integrase. Nature, 618, 2023
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8FYD
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![BU of 8fyd by Molmil](/molmil-images/mine/8fyd) | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex bent CRISPR repeat conformation | Descriptor: | Cas1, Cas2-DEDDh, DNA (13-MER), ... | Authors: | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | Deposit date: | 2023-01-25 | Release date: | 2023-05-03 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Genome expansion by a CRISPR trimmer-integrase. Nature, 618, 2023
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8FYA
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![BU of 8fya by Molmil](/molmil-images/mine/8fya) | Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-containing prespacer complex | Descriptor: | Cas1, Cas2-DEDDh, DNA (28-MER), ... | Authors: | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | Deposit date: | 2023-01-25 | Release date: | 2023-05-03 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (2.91 Å) | Cite: | Genome expansion by a CRISPR trimmer-integrase. Nature, 618, 2023
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3LPJ
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![BU of 3lpj by Molmil](/molmil-images/mine/3lpj) | Structure of BACE Bound to SCH743641 | Descriptor: | Beta-secretase 1, L(+)-TARTARIC ACID, N'-[(1S,2S)-2-[(2R)-4-benzylpiperazin-2-yl]-1-(3,5-difluorobenzyl)-2-hydroxyethyl]-5-methyl-N,N-dipropylbenzene-1,3-dicarboxamide | Authors: | Strickland, C, Cumming, J. | Deposit date: | 2010-02-05 | Release date: | 2010-04-14 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization. Bioorg.Med.Chem.Lett., 20, 2010
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7X08
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![BU of 7x08 by Molmil](/molmil-images/mine/7x08) | S protein of SARS-CoV-2 in complex with 2G1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, LINOLEIC ACID, ... | Authors: | Guo, Y.Y, Zhang, Y.Y, Zhou, Q. | Deposit date: | 2022-02-21 | Release date: | 2022-03-09 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to the tip of RBD. Cell Discov, 8, 2022
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7W6A
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![BU of 7w6a by Molmil](/molmil-images/mine/7w6a) | Crystal structure of the MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L complex | Descriptor: | Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Zhao, L, Li, Y, Chen, Y. | Deposit date: | 2021-12-01 | Release date: | 2022-09-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
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7W6I
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![BU of 7w6i by Molmil](/molmil-images/mine/7w6i) | The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me1 peptide | Descriptor: | Histone H3.3C, Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, ... | Authors: | Zhao, L, Li, Y, Chen, Y. | Deposit date: | 2021-12-01 | Release date: | 2022-09-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
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7W6L
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![BU of 7w6l by Molmil](/molmil-images/mine/7w6l) | The crystal structure of MLL3-RBBP5-ASH2L in complex with H3K4me0 peptide | Descriptor: | Histone H3.3C, Histone-lysine N-methyltransferase 2C, Retinoblastoma-binding protein 5, ... | Authors: | Zhao, L, Li, Y, Chen, Y. | Deposit date: | 2021-12-01 | Release date: | 2022-09-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
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7W67
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![BU of 7w67 by Molmil](/molmil-images/mine/7w67) | The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me0 peptide | Descriptor: | Histone H3.3C, Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, ... | Authors: | Zhao, L, Li, Y, Chen, Y. | Deposit date: | 2021-12-01 | Release date: | 2022-09-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.194 Å) | Cite: | Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
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7W6J
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![BU of 7w6j by Molmil](/molmil-images/mine/7w6j) | The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me2 peptide | Descriptor: | Histone H3.3C, Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, ... | Authors: | Zhao, L, Li, Y, Chen, Y. | Deposit date: | 2021-12-01 | Release date: | 2022-09-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
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8G5U
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![BU of 8g5u by Molmil](/molmil-images/mine/8g5u) | Crystal structure of TnmK2 complexed with TNM B | Descriptor: | TnmK2, methyl (2E)-3-[(1aS,11S,11aS,14Z,18R)-3,18-dihydroxy-4,9-dioxo-4,9,10,11-tetrahydro-11aH-11,1a-hept[3]ene[1,5]diynonaphtho[2,3-h]oxireno[c]quinolin-11a-yl]but-2-enoate | Authors: | Liu, Y.-C, Gui, C, Shen, B. | Deposit date: | 2023-02-14 | Release date: | 2023-10-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.804 Å) | Cite: | Cofactorless oxygenases guide anthraquinone-fused enediyne biosynthesis. Nat.Chem.Biol., 20, 2024
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8G5T
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![BU of 8g5t by Molmil](/molmil-images/mine/8g5t) | Crystal structure of apo TnmK2 | Descriptor: | TnmK2 | Authors: | Liu, Y.-C, Gui, C, Shen, B. | Deposit date: | 2023-02-14 | Release date: | 2023-10-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.846 Å) | Cite: | Cofactorless oxygenases guide anthraquinone-fused enediyne biosynthesis. Nat.Chem.Biol., 20, 2024
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8H77
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![BU of 8h77 by Molmil](/molmil-images/mine/8h77) | Hsp90-AhR-p23-XAP2 complex | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, AH receptor-interacting protein, Aryl hydrocarbon receptor, ... | Authors: | Wen, Z.L, Zhai, Y.J, Zhu, Y, Sun, F. | Deposit date: | 2022-10-19 | Release date: | 2023-01-04 | Last modified: | 2023-03-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structure of the cytosolic AhR complex. Structure, 31, 2023
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8HNZ
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![BU of 8hnz by Molmil](/molmil-images/mine/8hnz) | Crystal structure of cytochrome P450 NasF5053 mutant E73S complexed with 6FCWP | Descriptor: | (3~{S},8~{a}~{S})-3-[(5-fluoranyl-1~{H}-indol-3-yl)methyl]-2,3,6,7,8,8~{a}-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, CALCIUM ION, Cytochrome P450-F5053, ... | Authors: | Ma, B.D, Tian, W, Qu, X, Kong, X.D. | Deposit date: | 2022-12-09 | Release date: | 2023-04-19 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Engineering the Substrate Specificity of a P450 Dimerase Enables the Collective Biosynthesis of Heterodimeric Tryptophan-Containing Diketopiperazines. Angew.Chem.Int.Ed.Engl., 62, 2023
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8HO1
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![BU of 8ho1 by Molmil](/molmil-images/mine/8ho1) | Crystal structure of cytochrome P450 NasF5053 mutant F387G | Descriptor: | CALCIUM ION, Cytochrome P450-F5053, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Ma, B.D, Tian, W, Qu, X, Kong, X.D. | Deposit date: | 2022-12-09 | Release date: | 2023-04-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Engineering the Substrate Specificity of a P450 Dimerase Enables the Collective Biosynthesis of Heterodimeric Tryptophan-Containing Diketopiperazines. Angew.Chem.Int.Ed.Engl., 62, 2023
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8HO0
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![BU of 8ho0 by Molmil](/molmil-images/mine/8ho0) | Crystal structure of cytochrome P450 NasF5053 mutant E73S complexed with 8FCWP | Descriptor: | (3~{S},8~{a}~{S})-3-[(7-fluoranyl-1~{H}-indol-3-yl)methyl]-2,3,6,7,8,8~{a}-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, CALCIUM ION, Cytochrome P450-F5053, ... | Authors: | Ma, B.D, Tian, W, Qu, X, Kong, X.D. | Deposit date: | 2022-12-09 | Release date: | 2023-04-19 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Engineering the Substrate Specificity of a P450 Dimerase Enables the Collective Biosynthesis of Heterodimeric Tryptophan-Containing Diketopiperazines. Angew.Chem.Int.Ed.Engl., 62, 2023
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8HNY
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![BU of 8hny by Molmil](/molmil-images/mine/8hny) | Crystal structure of cytochrome P450 NasF5053 mutant E73S complexed with 5FCWP | Descriptor: | (3~{S},8~{a}~{S})-3-[(4-fluoranyl-1~{H}-indol-3-yl)methyl]-2,3,6,7,8,8~{a}-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione, Cytochrome P450-F5053, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Ma, B.D, Tian, W, Qu, X, Kong, X.D. | Deposit date: | 2022-12-09 | Release date: | 2023-04-26 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Engineering the Substrate Specificity of a P450 Dimerase Enables the Collective Biosynthesis of Heterodimeric Tryptophan-Containing Diketopiperazines. Angew.Chem.Int.Ed.Engl., 62, 2023
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7XSV
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![BU of 7xsv by Molmil](/molmil-images/mine/7xsv) | Crystal Structures of PIM1 in Complex with Macrocyclic Compound H3 | Descriptor: | 8-Methyl-2,5,20-trioxa-8,13,17-triazatetracyclo[11.10.2.014,19.021,25]pentacosa-1(24),14(19),15,17,21(25),22-hexaene, Serine/threonine-protein kinase pim-1 | Authors: | Shen, C, Xie, Y, Ren, X, Zhou, Y, Niu, H. | Deposit date: | 2022-05-15 | Release date: | 2022-07-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Design, synthesis, and bioactivity evaluation of macrocyclic benzo[b]pyrido[4,3-e][1,4]oxazine derivatives as novel Pim-1 kinase inhibitors. Bioorg.Med.Chem.Lett., 72, 2022
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2L89
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![BU of 2l89 by Molmil](/molmil-images/mine/2l89) | |
5CHL
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![BU of 5chl by Molmil](/molmil-images/mine/5chl) | Structural basis of H2A.Z recognition by YL1 histone chaperone component of SRCAP/SWR1 chromatin remodeling complex | Descriptor: | Histone H2A.Z, Vacuolar protein sorting-associated protein 72 homolog | Authors: | Shan, S, Liang, X, Pan, L, Wu, C, Zhou, Z. | Deposit date: | 2015-07-10 | Release date: | 2016-03-09 | Last modified: | 2017-09-27 | Method: | X-RAY DIFFRACTION (1.892 Å) | Cite: | Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1 Nat.Struct.Mol.Biol., 23, 2016
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