1D8M
| CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A HETEROCYCLE-BASED INHIBITOR | Descriptor: | 1-BENZYL-3-(4-METHOXY-BENZENESULFONYL)-6-OXO-HEXAHYDRO-PYRIMIDINE-4-CARBOXYLIC ACID HYDROXYAMIDE, CALCIUM ION, STROMELYSIN-1 PRECURSOR, ... | Authors: | Pikul, S, Dunham, K.M, Almstead, N.G, De, B, Natchus, M.G, Taiwo, Y.O, Williams, L.E, Hynd, B.A, Hsieh, L.C, Janusz, M.J, Gu, F, Mieling, G.E. | Deposit date: | 1999-10-25 | Release date: | 2000-10-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Heterocycle-based MMP inhibitors with P2' substituents. Bioorg.Med.Chem.Lett., 11, 2001
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1G05
| HETEROCYCLE-BASED MMP INHIBITOR WITH P2'SUBSTITUENTS | Descriptor: | 1-BENZYL-3-(4-METHOXY-BENZENESULFONYL)-6-OXO-HEXAHYDRO-PYRIMIDINE-4-CARBOXYLIC ACID HYDROXYAMIDE, CALCIUM ION, STROMELYSIN-1 PRECURSOR, ... | Authors: | Pikul, S, Dunham, K.M, Almstead, N.G, De, B, Natchus, M.G, Taiwo, Y.O, Williams, L.E, Hynd, B.A, Hsieh, L.C, Janusz, M.J. | Deposit date: | 2000-10-05 | Release date: | 2001-10-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Heterocycle-based MMP inhibitors with P2' substituents. Bioorg.Med.Chem.Lett., 11, 2001
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6XO4
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6XOB
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7V0N
| Cryo-EM structure of SINV/EEEV in complex with Fab fragment of a moderately/weakly neutralizing human antibody IgG-21 | Descriptor: | IgG 21 Fab heavy chain, IgG 21 Fab light chain, Spike glycoprotein E1, ... | Authors: | Bandyopadhyay, A, Klose, T, Kuhn, R.J. | Deposit date: | 2022-05-10 | Release date: | 2023-04-05 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies. Proc.Natl.Acad.Sci.USA, 120, 2023
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7V0O
| Cryo-EM structure of SINV/EEEV in complex with Fab fragment of a moderately/weakly neutralizing human antibody IgG-94 | Descriptor: | IgG 94 Fab heavy chain, IgG 94 Fab light chain, Spike glycoprotein E1, ... | Authors: | Bandyopadhyay, A, Klose, T, Kuhn, R.J. | Deposit date: | 2022-05-10 | Release date: | 2023-04-05 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (6.6 Å) | Cite: | Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies. Proc.Natl.Acad.Sci.USA, 120, 2023
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7V0P
| Cryo-EM structure of SINV/EEEV in complex with Fab fragment of a potently neutralizing human antibody IgG-106 | Descriptor: | IgG 106 Fab heavy chain, IgG 106 Fab light chain, Spike glycoprotein E1, ... | Authors: | Bandyopadhyay, A, Klose, T, Kuhn, R.J. | Deposit date: | 2022-05-10 | Release date: | 2023-04-05 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (5.2 Å) | Cite: | Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies. Proc.Natl.Acad.Sci.USA, 120, 2023
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1D5J
| CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A THIAZEPINE BASED INHIBITOR. | Descriptor: | CALCIUM ION, N-HYDROXY-4-[(4-METHOXYLPHENYL)SULFONYL]-2,2-DIMETHYL-HEXAHYDRO-1,4-THIAZEPINE-3(S)-CARBOXAMIDE, STROMELYSIN-1, ... | Authors: | Almstead, N.G, Bradley, R.S, Pikul, S, De, B, Natchus, M.G. | Deposit date: | 1999-10-07 | Release date: | 2000-10-09 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Design, synthesis, and biological evaluation of potent thiazine- and thiazepine-based matrix metalloproteinase inhibitors. J.Med.Chem., 42, 1999
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1Q3A
| Crystal structure of the catalytic domain of human matrix metalloproteinase 10 | Descriptor: | CALCIUM ION, N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID, Stromelysin-2, ... | Authors: | Calderone, V, Bertini, I, Fragai, M, Luchinat, C, Mangani, S, Terni, B. | Deposit date: | 2003-07-29 | Release date: | 2004-04-06 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of the catalytic domain of human matrix metalloproteinase 10. J.Mol.Biol., 336, 2004
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5WEQ
| The crystal structure of a MR78 mutant | Descriptor: | MR78 mutant Fab heavy chain, MR78 mutant light chain | Authors: | Dong, J, Williamson, L.E, Crowe, J.E. | Deposit date: | 2017-07-10 | Release date: | 2018-04-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein. Structure, 25, 2017
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6WDT
| Enterovirus D68 in complex with human monoclonal antibody EV68-228 | Descriptor: | EV68-228 heavy chain, EV68-228 light chain, viral protein 1, ... | Authors: | Fu, J, Vogt, M.R, Klose, T, Crowe, J.E, Rossmann, M.G, Kuhn, R.J, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2020-04-01 | Release date: | 2020-07-15 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease. Sci Immunol, 5, 2020
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6WDS
| Enterovirus D68 in complex with human monoclonal antibody EV68-159 | Descriptor: | EV68-159 heavy chain, EV68-159 light chain, viral protein 1, ... | Authors: | Fu, J, Klose, T, Vogt, M.R, Crowe, J.E, Rossmann, M.G, Kuhn, R.J, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2020-04-01 | Release date: | 2020-07-15 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Human antibodies neutralize enterovirus D68 and protect against infection and paralytic disease. Sci Immunol, 5, 2020
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7SFU
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7SFW
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7SFV
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8EAY
| HMPV F complex with 4I3 Fab | Descriptor: | 4I3 heavy chain protein, 4I3 light chain protein, Fusion glycoprotein F0 | Authors: | Wen, X, Jardetzky, T.S. | Deposit date: | 2022-08-30 | Release date: | 2023-08-16 | Last modified: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (3.33 Å) | Cite: | Potent cross-neutralization of respiratory syncytial virus and human metapneumovirus through a structurally conserved antibody recognition mode. Cell Host Microbe, 31, 2023
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8E2U
| HMPV F monomer bound to RSV-199 Fab | Descriptor: | Fusion glycoprotein F0, RSV-199 heavy chain, RSV-199 light chain | Authors: | Wen, X, Jardetzky, T.S. | Deposit date: | 2022-08-16 | Release date: | 2023-08-16 | Last modified: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (3.48 Å) | Cite: | Potent cross-neutralization of respiratory syncytial virus and human metapneumovirus through a structurally conserved antibody recognition mode. Cell Host Microbe, 31, 2023
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8EBP
| HMPV F dimer bound to RSV-199 Fab | Descriptor: | Fusion glycoprotein F0, RSV-199 heavy chain protein, RSV-199 light chain protein | Authors: | Wen, X, Jardetzky, T.S. | Deposit date: | 2022-08-31 | Release date: | 2023-08-16 | Last modified: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Potent cross-neutralization of respiratory syncytial virus and human metapneumovirus through a structurally conserved antibody recognition mode. Cell Host Microbe, 31, 2023
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8DZW
| RSV F trimer bound to RSV-199 Fab | Descriptor: | RSV fusion protein, RSV-199 Heavy chain protein, RSV-199 Light chain protein | Authors: | Wen, X, Jardetzky, T.S. | Deposit date: | 2022-08-08 | Release date: | 2023-08-16 | Last modified: | 2023-08-23 | Method: | ELECTRON MICROSCOPY (2.46 Å) | Cite: | Potent cross-neutralization of respiratory syncytial virus and human metapneumovirus through a structurally conserved antibody recognition mode. Cell Host Microbe, 31, 2023
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7KEW
| Bundibugyo virus GP (mucin deleted) bound to antibody Fab BDBV-43 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BDBV-43 Fab heavy chain, ... | Authors: | Murin, C.D, Ward, A.B. | Deposit date: | 2020-10-13 | Release date: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (4.16 Å) | Cite: | Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies. Cell Rep, 35, 2021
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7KFG
| Antibody Fab BDBV-289 | Descriptor: | Antibody Fab BDBV-289 heavy chain, Antibody Fab BDBV-289 light chain, DI(HYDROXYETHYL)ETHER | Authors: | Murin, C.D, Bruhn, J.F, Ward, A.B. | Deposit date: | 2020-10-13 | Release date: | 2021-04-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.002 Å) | Cite: | Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies. Cell Rep, 35, 2021
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7KFE
| Bundibugyo virus GP (mucin deleted) bound to antibody Fab BDBV-329 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody BDBV-329 heavy chain, ... | Authors: | Murin, C.D, Ward, A.B. | Deposit date: | 2020-10-13 | Release date: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (6.6 Å) | Cite: | Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies. Cell Rep, 35, 2021
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7KFH
| Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-437 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab EBOV-437 heavy chain, ... | Authors: | Murin, C.D, Ward, A.B. | Deposit date: | 2020-10-13 | Release date: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies. Cell Rep, 35, 2021
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7KFB
| Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-442 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab EBOV-442 heavy chain, ... | Authors: | Murin, C.D, Ward, A.B. | Deposit date: | 2020-10-13 | Release date: | 2021-04-28 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies. Cell Rep, 35, 2021
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7KEX
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