1G05

HETEROCYCLE-BASED MMP INHIBITOR WITH P2'SUBSTITUENTS

Summary for 1G05

Entry DOI	10.2210/pdb1g05/pdb
Related	1CQR 1D5J 1D7X 1D8F 1D8M
Descriptor	STROMELYSIN-1 PRECURSOR, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	mixed alpha beta structure, zinc protease, inhibited, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix (Probable): P08254
Total number of polymer chains	2
Total formula weight	39754.61
Authors	Pikul, S.,Dunham, K.M.,Almstead, N.G.,De, B.,Natchus, M.G.,Taiwo, Y.O.,Williams, L.E.,Hynd, B.A.,Hsieh, L.C.,Janusz, M.J. (deposition date: 2000-10-05, release date: 2001-10-05, Last modification date: 2024-02-07)
Primary citation	Pikul, S.,Dunham, K.M.,Almstead, N.G.,De, B.,Natchus, M.G.,Taiwo, Y.O.,Williams, L.E.,Hynd, B.A.,Hsieh, L.C.,Janusz, M.J.,Gu, F.,Mieling, G.E. Heterocycle-based MMP inhibitors with P2' substituents. Bioorg.Med.Chem.Lett., 11:1009-1013, 2001 Cited by PubMed: 11327577 DOI: 10.1016/S0960-894X(01)00137-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation