1D7X
CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A MODIFIED PROLINE SCAFFOLD BASED INHIBITOR.
Summary for 1D7X
Entry DOI | 10.2210/pdb1d7x/pdb |
Related | 1CQR 1D5J |
Descriptor | STROMELYSIN-1 PRECURSOR, ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | mixed alpha beta structure, zinc protease, inhibited, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space, extracellular matrix (Probable): P08254 |
Total number of polymer chains | 2 |
Total formula weight | 40025.90 |
Authors | Cheng, M.Y.,Natchus, M.G.,De, B.,Almstead, N.G.,Pikul, S. (deposition date: 1999-10-20, release date: 2000-10-23, Last modification date: 2024-02-07) |
Primary citation | Cheng, M.,De, B.,Almstead, N.G.,Pikul, S.,Dowty, M.E.,Dietsch, C.R.,Dunaway, C.M.,Gu, F.,Hsieh, L.C.,Janusz, M.J.,Taiwo, Y.O.,Natchus, M.G.,Hudlicky, T.,Mandel, M. Design, synthesis, and biological evaluation of matrix metalloproteinase inhibitors derived from a modified proline scaffold. J.Med.Chem., 42:5426-5436, 1999 Cited by PubMed: 10639284DOI: 10.1021/jm9904699 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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