1D8M

CRYSTAL STRUCTURE OF MMP3 COMPLEXED WITH A HETEROCYCLE-BASED INHIBITOR

Summary for 1D8M

• Entry DOI: 10.2210/pdb1d8m/pdb
• Related: 1CQR 1D5J 1D7X 1D8F
• Descriptor: STROMELYSIN-1 PRECURSOR, ZINC ION, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: mixed alpha beta structure, zinc protease, inhibited, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Secreted, extracellular space, extracellular matrix (Probable): P08254
• Total number of polymer chains: 2
• Total formula weight: 39754.61

Authors

Pikul, S.,Dunham, K.M.,Almstead, N.G.,De, B.,Natchus, M.G.,Taiwo, Y.O.,Williams, L.E.,Hynd, B.A.,Hsieh, L.C.,Janusz, M.J.,Gu, F.,Mieling, G.E. (deposition date: 1999-10-25, release date: 2000-10-25, Last modification date: 2024-02-07)

• Primary citation: Pikul, S.,Dunham, K.M.,Almstead, N.G.,De, B.,Natchus, M.G.,Taiwo, Y.O.,Williams, L.E.,Hynd, B.A.,Hsieh, L.C.,Janusz, M.J.,Gu, F.,Mieling, G.E.; Heterocycle-based MMP inhibitors with P2' substituents.; Bioorg.Med.Chem.Lett., 11:1009-1013, 2001; PubMed: 11327577; DOI: 10.1016/S0960-894X(01)00137-8

Experimental method

X-RAY DIFFRACTION (2.44 Å)