2NLL
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![BU of 2nll by Molmil](/molmil-images/mine/2nll) | RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA | Descriptor: | DNA (5'-D(*CP*AP*GP*GP*TP*CP*AP*TP*TP*(5IU)P*CP*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*GP*AP*AP*AP*TP*GP*AP*CP*CP*T P*G)-3'), PROTEIN (RETINOIC ACID RECEPTOR), ... | Authors: | Rastinejad, F, Perlmann, T, Evans, R.M, Sigler, P.B. | Deposit date: | 1996-11-20 | Release date: | 1997-03-12 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural determinants of nuclear receptor assembly on DNA direct repeats. Nature, 375, 1995
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1DSZ
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![BU of 1dsz by Molmil](/molmil-images/mine/1dsz) | STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1 | Descriptor: | DNA (5'-D(*CP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*G)-3'), RETINOIC ACID RECEPTOR ALPHA, ... | Authors: | Rastinejad, F, Wagner, T, Zhao, Q, Khorasanizadeh, S. | Deposit date: | 2000-01-10 | Release date: | 2000-07-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1. EMBO J., 19, 2000
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2AG9
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![BU of 2ag9 by Molmil](/molmil-images/mine/2ag9) | Crystal Structure of the Y137S mutant of GM2-Activator Protein | Descriptor: | Ganglioside GM2 activator, ISOPROPYL ALCOHOL, MYRISTIC ACID | Authors: | Wright, C.S, Mi, L.Z, Lee, S, Rastinejad, F. | Deposit date: | 2005-07-26 | Release date: | 2005-10-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure Analysis of Phosphatidylcholine-GM2-Activator Product Complexes: Evidence for Hydrolase Activity. Biochemistry, 44, 2005
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2AGC
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![BU of 2agc by Molmil](/molmil-images/mine/2agc) | Crystal Structure of mouse GM2- activator Protein | Descriptor: | Ganglioside GM2 activator, LAURIC ACID, MYRISTIC ACID | Authors: | Wright, C.S, Mi, L.Z, Lee, S, Rastinejad, F. | Deposit date: | 2005-07-26 | Release date: | 2005-10-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure Analysis of Phosphatidylcholine-GM2-Activator Product Complexes: Evidence for Hydrolase Activity. Biochemistry, 44, 2005
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2AG4
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![BU of 2ag4 by Molmil](/molmil-images/mine/2ag4) | Crystal Structure Analysis of GM2-activator protein complexed with phosphatidylcholine | Descriptor: | (7R)-4,7-DIHYDROXY-N,N,N-TRIMETHYL-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEPTACOSAN-1-AMINIUM 4-OXIDE, Ganglioside GM2 activator, ISOPROPYL ALCOHOL, ... | Authors: | Wright, C.S, Mi, L.Z, Lee, S, Rastinejad, F. | Deposit date: | 2005-07-26 | Release date: | 2005-10-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure Analysis of Phosphatidylcholine-GM2-Activator Product Complexes: Evidence for Hydrolase Activity. Biochemistry, 44, 2005
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4ZPH
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![BU of 4zph by Molmil](/molmil-images/mine/4zph) | Crystal Structure of the Heterodimeric HIF-2a:ARNT Complex with Proflavine | Descriptor: | Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, PROFLAVIN | Authors: | Wu, D, Potluri, N, Lu, J, Kim, Y, Rastinejad, F. | Deposit date: | 2015-05-07 | Release date: | 2015-08-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural integration in hypoxia-inducible factors. Nature, 524, 2015
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2AF9
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![BU of 2af9 by Molmil](/molmil-images/mine/2af9) | Crystal Structure analysis of GM2-Activator protein complexed with phosphatidylcholine | Descriptor: | Ganglioside GM2 activator, ISOPROPYL ALCOHOL, LAURIC ACID, ... | Authors: | Wright, C.S, Mi, L.Z, Lee, S, Rastinejad, F. | Deposit date: | 2005-07-25 | Release date: | 2005-10-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure Analysis of Phosphatidylcholine-GM2-Activator Product Complexes: Evidence for Hydrolase Activity. Biochemistry, 44, 2005
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2AG2
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![BU of 2ag2 by Molmil](/molmil-images/mine/2ag2) | Crystal Structure Analysis of GM2-activator protein complexed with Phosphatidylcholine | Descriptor: | (7R)-4,7-DIHYDROXY-N,N,N-TRIMETHYL-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEPTACOSAN-1-AMINIUM 4-OXIDE, 2-(((R)-2,3-DIHYDROXYPROPYL)PHOSPHORYLOXY)-N,N,N-TRIMETHYLETHANAMINIUM, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Wright, C.S, Mi, L.Z, Lee, S, Rastinejad, F. | Deposit date: | 2005-07-26 | Release date: | 2005-10-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure Analysis of Phosphatidylcholine-GM2-Activator Product Complexes: Evidence for Hydrolase Activity. Biochemistry, 44, 2005
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1GA5
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![BU of 1ga5 by Molmil](/molmil-images/mine/1ga5) | CRYSTAL STRUCTURE OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB(ALPHA) DNA-BINDING DOMAIN BOUND TO ITS COGNATE RESPONSE ELEMENT | Descriptor: | 5'-D(*CP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*CP*TP*AP*GP*GP*TP*CP*AP*G)-3', 5'-D(*CP*TP*GP*AP*CP*CP*TP*AP*GP*TP*GP*AP*CP*CP*TP*AP*GP*TP*(5IT)P*G)-3', ORPHAN NUCLEAR RECEPTOR NR1D1, ... | Authors: | Sierk, M.L, Zhao, Q, Rastinejad, F. | Deposit date: | 2000-11-29 | Release date: | 2001-11-16 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | DNA Deformability as a Recognition Feature in the RevErb Response Element Biochemistry, 40, 2001
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1HLZ
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![BU of 1hlz by Molmil](/molmil-images/mine/1hlz) | CRYSTAL STRUCTURE OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB(ALPHA) DNA-BINDING DOMAIN BOUND TO ITS COGNATE RESPONSE ELEMENT | Descriptor: | 5'-D(*CP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*CP*TP*AP*GP*GP*TP*CP*AP*G)-3', 5'-D(*CP*TP*GP*AP*CP*CP*TP*AP*GP*TP*GP*AP*CP*CP*TP*AP*GP*TP*TP*G)-3', ORPHAN NUCLEAR RECEPTOR NR1D1, ... | Authors: | Sierk, M.L, Zhao, Q, Rastinejad, F. | Deposit date: | 2000-12-04 | Release date: | 2001-11-16 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | DNA Deformability as a Recognition Feature in the RevErb Response Element Biochemistry, 40, 2001
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4M4X
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![BU of 4m4x by Molmil](/molmil-images/mine/4m4x) | |
4IQR
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![BU of 4iqr by Molmil](/molmil-images/mine/4iqr) | Multi-Domain Organization of the HNF4alpha Nuclear Receptor Complex on DNA | Descriptor: | DNA (5'-D(*CP*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*GP*TP*TP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3'), Hepatocyte nuclear factor 4-alpha, ... | Authors: | Chandra, V, Huang, P, Kim, Y, Rastinejad, F. | Deposit date: | 2013-01-13 | Release date: | 2013-03-20 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Multidomain integration in the structure of the HNF-4 alpha nuclear receptor complex. Nature, 495, 2013
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1TJJ
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![BU of 1tjj by Molmil](/molmil-images/mine/1tjj) | Human GM2 Activator Protein PAF complex | Descriptor: | (2R)-2-(acetyloxy)-3-(hexadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Wright, C.S, Mi, L.-Z, Rastinejad, F. | Deposit date: | 2004-06-04 | Release date: | 2004-12-07 | Last modified: | 2013-10-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Evidence for lipid packaging in the crystal structure of the GM2-activator complex with platelet activating factor J.Mol.Biol., 342, 2004
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3OA6
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![BU of 3oa6 by Molmil](/molmil-images/mine/3oa6) | Human MSL3 Chromodomain bound to DNA and H4K20me1 peptide | Descriptor: | DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*G)-3'), DNA (5'-D(*GP*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*A)-3'), H4 peptide monomethylated at lysine 20, ... | Authors: | Kim, D, Huang, P, Rastinejad, F, Khorasanizadeh, S. | Deposit date: | 2010-08-04 | Release date: | 2010-08-18 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain. Nat.Struct.Mol.Biol., 17, 2010
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3M9Q
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![BU of 3m9q by Molmil](/molmil-images/mine/3m9q) | |
1G13
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![BU of 1g13 by Molmil](/molmil-images/mine/1g13) | HUMAN GM2 ACTIVATOR STRUCTURE | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GANGLIOSIDE M2 ACTIVATOR PROTEIN | Authors: | Wright, C.S, Li, S.C, Rastinejad, F. | Deposit date: | 2000-10-10 | Release date: | 2001-04-11 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of human GM2-activator protein with a novel beta-cup topology. J.Mol.Biol., 304, 2000
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4S14
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![BU of 4s14 by Molmil](/molmil-images/mine/4s14) | Crystal structure of the orphan nuclear receptor RORgamma ligand-binding domain in complex with 4alpha-caboxyl, 4beta-methyl-zymosterol (4ACD8) | Descriptor: | (3beta,4alpha,5beta,14beta)-3-hydroxy-4-methylcholesta-8,24-diene-4-carboxylic acid, Nuclear receptor ROR-gamma, Nuclear receptor-interacting protein 1 | Authors: | Huang, P, Santori, F.R, Littman, D.R, Rastinejad, F. | Deposit date: | 2015-01-07 | Release date: | 2015-02-11 | Last modified: | 2015-02-25 | Method: | X-RAY DIFFRACTION (3.542 Å) | Cite: | Identification of Natural ROR gamma Ligands that Regulate the Development of Lymphoid Cells. Cell Metab, 21, 2015
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4S15
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![BU of 4s15 by Molmil](/molmil-images/mine/4s15) | Crystal structure of the orphan nuclear receptor RORalpha ligand-binding domain in complex with 4alpha-caboxyl, 4beta-methyl-zymosterol (4ACD8) | Descriptor: | (3beta,4alpha,5beta,14beta)-3-hydroxy-4-methylcholesta-8,24-diene-4-carboxylic acid, GLYCEROL, Nuclear receptor ROR-alpha, ... | Authors: | Huang, P, Santori, F.R, Littman, D.R, Rastinejad, F. | Deposit date: | 2015-01-08 | Release date: | 2015-02-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.897 Å) | Cite: | Identification of Natural ROR gamma Ligands that Regulate the Development of Lymphoid Cells. Cell Metab, 21, 2015
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2B2W
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![BU of 2b2w by Molmil](/molmil-images/mine/2b2w) | Tandem chromodomains of human CHD1 complexed with Histone H3 Tail containing trimethyllysine 4 | Descriptor: | Chromodomain-helicase-DNA-binding protein 1, Histone H3 | Authors: | Flanagan IV, J.F, Mi, L.-Z, Chruszcz, M, Cymborowski, M, Clines, K.L, Kim, Y, Minor, W, Rastinejad, F, Khorasanizadeh, S. | Deposit date: | 2005-09-19 | Release date: | 2005-12-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Double chromodomains cooperate to recognize the methylated histone H3 tail. Nature, 438, 2005
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2B2T
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![BU of 2b2t by Molmil](/molmil-images/mine/2b2t) | Tandem chromodomains of human CHD1 complexed with Histone H3 Tail containing trimethyllysine 4 and phosphothreonine 3 | Descriptor: | Chromodomain-helicase-DNA-binding protein 1, Histone H3 tail | Authors: | Flanagan IV, J.F, Mi, L.-Z, Chruszcz, M, Cymborowski, M, Clines, K.L, Kim, Y, Minor, W, Rastinejad, F, Khorasanizadeh, S. | Deposit date: | 2005-09-19 | Release date: | 2005-12-27 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Double chromodomains cooperate to recognize the methylated histone H3 tail. Nature, 438, 2005
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2B2Y
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![BU of 2b2y by Molmil](/molmil-images/mine/2b2y) | Tandem chromodomains of human CHD1 | Descriptor: | Chromodomain-helicase-DNA-binding protein 1 | Authors: | Flanagan IV, J.F, Mi, L.-Z, Chruszcz, M, Cymborowski, M, Clines, K.L, Kim, Y, Minor, W, Rastinejad, F, Khorasanizadeh, S. | Deposit date: | 2005-09-19 | Release date: | 2005-12-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Double chromodomains cooperate to recognize the methylated histone H3 tail. Nature, 438, 2005
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2B2V
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![BU of 2b2v by Molmil](/molmil-images/mine/2b2v) | Crystal structure analysis of human CHD1 chromodomains 1 and 2 bound to histone H3 resi 1-15 MeK4 | Descriptor: | Chromodomain-helicase-DNA-binding protein 1, Histone H3 | Authors: | Flanagan IV, J.F, Mi, L.-Z, Chruszcz, M, Cymborowski, M, Clines, K.L, Kim, Y, Minor, W, Rastinejad, F, Khorasanizadeh, S. | Deposit date: | 2005-09-19 | Release date: | 2005-12-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Double chromodomains cooperate to recognize the methylated histone H3 tail. Nature, 438, 2005
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2B2U
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![BU of 2b2u by Molmil](/molmil-images/mine/2b2u) | Tandem chromodomains of human CHD1 complexed with Histone H3 Tail containing trimethyllysine 4 and dimethylarginine 2 | Descriptor: | Chromodomain-helicase-DNA-binding protein 1, Histone H3 | Authors: | Flanagan IV, J.F, Mi, L.-Z, Chruszcz, M, Cymborowski, M, Clines, K.L, Kim, Y, Minor, W, Rastinejad, F, Khorasanizadeh, S. | Deposit date: | 2005-09-19 | Release date: | 2005-12-27 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Double chromodomains cooperate to recognize the methylated histone H3 tail. Nature, 438, 2005
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3DZY
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![BU of 3dzy by Molmil](/molmil-images/mine/3dzy) | Intact PPAR gamma - RXR alpha Nuclear Receptor Complex on DNA bound with Rosiglitazone, 9-cis Retinoic Acid and NCOA2 Peptide | Descriptor: | (9cis)-retinoic acid, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), ... | Authors: | Chandra, V, Huang, P, Hamuro, Y, Raghuram, S, Wang, Y, Burris, T.P, Rastinejad, F. | Deposit date: | 2008-07-30 | Release date: | 2008-10-28 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. Nature, 456, 2008
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3DZU
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![BU of 3dzu by Molmil](/molmil-images/mine/3dzu) | Intact PPAR gamma - RXR alpha Nuclear Receptor Complex on DNA bound with BVT.13, 9-cis Retinoic Acid and NCOA2 Peptide | Descriptor: | (9cis)-retinoic acid, 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID, DNA (5'-D(*DCP*DAP*DAP*DAP*DCP*DTP*DAP*DGP*DGP*DTP*DCP*DAP*DAP*DAP*DGP*DGP*DTP*DCP*DAP*DG)-3'), ... | Authors: | Chandra, V, Huang, P, Hamuro, Y, Raghuram, S, Wang, Y, Burris, T.P, Rastinejad, F. | Deposit date: | 2008-07-30 | Release date: | 2008-10-28 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. Nature, 456, 2008
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