2AG9

Crystal Structure of the Y137S mutant of GM2-Activator Protein

Summary for 2AG9

Entry DOI	10.2210/pdb2ag9/pdb
Related	1G13 1PU5 1PUB 1TJJ 2AG2 2AG4
Descriptor	Ganglioside GM2 activator, ISOPROPYL ALCOHOL, MYRISTIC ACID, ... (4 entities in total)
Functional Keywords	conformational changes in mobile loop (w131 loop), lipid binding protein
Biological source	Homo sapiens (human)
Cellular location	Lysosome: P17900
Total number of polymer chains	2
Total formula weight	36572.62
Authors	Wright, C.S.,Mi, L.Z.,Lee, S.,Rastinejad, F. (deposition date: 2005-07-26, release date: 2005-10-25, Last modification date: 2023-08-23)
Primary citation	Wright, C.S.,Mi, L.Z.,Lee, S.,Rastinejad, F. Crystal Structure Analysis of Phosphatidylcholine-GM2-Activator Product Complexes: Evidence for Hydrolase Activity. Biochemistry, 44:13510-13521, 2005 Cited by PubMed: 16216074 DOI: 10.1021/bi050668w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation