1EPB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1epb by Molmil](/molmil-images/mine/1epb) | |
1EPA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1epa by Molmil](/molmil-images/mine/1epa) | |
1BI9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1bi9 by Molmil](/molmil-images/mine/1bi9) | RETINAL DEHYDROGENASE TYPE TWO WITH NAD BOUND | Descriptor: | CHLORIDE ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, RETINAL DEHYDROGENASE TYPE II | Authors: | Newcomer, M.E, Lamb, A.L. | Deposit date: | 1998-06-23 | Release date: | 1999-07-22 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The structure of retinal dehydrogenase type II at 2.7 A resolution: implications for retinal specificity. Biochemistry, 38, 1999
|
|
3O8Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3o8y by Molmil](/molmil-images/mine/3o8y) | Stable-5-Lipoxygenase | Descriptor: | Arachidonate 5-lipoxygenase, FE (II) ION | Authors: | Newcomer, M.E, Gilbert, N.C, Bartlett, S.G, Waight, M.T, Neau, D.B, Boeglin, W.E, Brash, A.R. | Deposit date: | 2010-08-03 | Release date: | 2011-01-19 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.389 Å) | Cite: | The structure of human 5-lipoxygenase. Science, 331, 2011
|
|
6N2W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6n2w by Molmil](/molmil-images/mine/6n2w) | The structure of Stable-5-Lipoxygenase bound to NDGA | Descriptor: | 4-[(2R,3S)-3-[(3,4-DIHYDROXYPHENYL)METHYL]-2-METHYLBUTYL]BENZENE-1,2-DIOL, Arachidonate 5-lipoxygenase, FE (II) ION | Authors: | Newcomer, M.E, Gilbert, N.C, Neau, D.B. | Deposit date: | 2018-11-14 | Release date: | 2020-05-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products. Nat.Chem.Biol., 16, 2020
|
|
6NCF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ncf by Molmil](/molmil-images/mine/6ncf) | The structure of Stable-5-Lipoxygenase bound to AKBA | Descriptor: | (3alpha,8alpha,17alpha,18alpha)-3-(acetyloxy)-11-oxours-12-en-23-oic acid, Arachidonate 5-lipoxygenase, FE (II) ION | Authors: | Newcomer, M.E, Gilbert, N.C, Neau, D.B. | Deposit date: | 2018-12-11 | Release date: | 2020-05-13 | Last modified: | 2020-07-08 | Method: | X-RAY DIFFRACTION (2.871 Å) | Cite: | Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products. Nat.Chem.Biol., 16, 2020
|
|
1U5U
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1u5u by Molmil](/molmil-images/mine/1u5u) | |
4QWT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4qwt by Molmil](/molmil-images/mine/4qwt) | |
6AUM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6aum by Molmil](/molmil-images/mine/6aum) | Crystal structure of human soluble epoxide hydrolase complexed with trans-4-[4-(3-trifluoromethoxyphenyl-l-ureido)-cyclohexyloxy]-benzoic acid. | Descriptor: | 4-{[trans-4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)cyclohexyl]oxy}benzoic acid, Bifunctional epoxide hydrolase 2, CHLORIDE ION, ... | Authors: | Kodani, S.D, Bahkta, S, Hwang, S.H, Pakhomova, S, Newcomer, M.E, Morisseau, C, Hammock, B. | Deposit date: | 2017-09-01 | Release date: | 2018-02-07 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase. Bioorg. Med. Chem. Lett., 28, 2018
|
|
5DD8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5dd8 by Molmil](/molmil-images/mine/5dd8) | The Crystal structure of HucR mutant (HucR-E48Q) from Deinococcus radiodurans | Descriptor: | CHLORIDE ION, Transcriptional regulator, MarR family | Authors: | Deochand, D.K, Perera, I.C, Crochet, R.B, Gilbert, N.C, Newcomer, M.E, Grove, A. | Deposit date: | 2015-08-24 | Release date: | 2015-09-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Histidine switch controlling pH-dependent protein folding and DNA binding in a transcription factor at the core of synthetic network devices. Mol Biosyst, 12, 2016
|
|
2P7L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2p7l by Molmil](/molmil-images/mine/2p7l) | Crystal structure of monoclinic form of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes at pH 5.75 | Descriptor: | GLYCEROL, Glyoxalase family protein | Authors: | Fillgrove, K.L, Pakhomova, S, Schaab, M, Newcomer, M.E, Armstrong, R.N. | Deposit date: | 2007-03-20 | Release date: | 2007-07-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure and Mechanism of the Genomically Encoded Fosfomycin Resistance Protein, FosX, from Listeria monocytogenes. Biochemistry, 46, 2007
|
|
2P7P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2p7p by Molmil](/molmil-images/mine/2p7p) | Crystal structure of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes complexed with MN(II) and sulfate ion | Descriptor: | Glyoxalase family protein, MANGANESE (II) ION, SULFATE ION | Authors: | Fillgrove, K.L, Pakhomova, S, Schaab, M, Newcomer, M.E, Armstrong, R.N. | Deposit date: | 2007-03-20 | Release date: | 2007-07-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.17 Å) | Cite: | Structure and Mechanism of the Genomically Encoded Fosfomycin Resistance Protein, FosX, from Listeria monocytogenes. Biochemistry, 46, 2007
|
|
2P7K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2p7k by Molmil](/molmil-images/mine/2p7k) | Crystal structure of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes (hexagonal form) | Descriptor: | CITRIC ACID, Glyoxalase family protein | Authors: | Fillgrove, K.L, Pakhomova, S, Schaab, M, Newcomer, M.E, Armstrong, R.N. | Deposit date: | 2007-03-20 | Release date: | 2007-07-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structure and Mechanism of the Genomically Encoded Fosfomycin Resistance Protein, FosX, from Listeria monocytogenes. Biochemistry, 46, 2007
|
|
2P7Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2p7q by Molmil](/molmil-images/mine/2p7q) | Crystal structure of E126Q mutant of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes complexed with MN(II) and 1S,2S-dihydroxypropylphosphonic acid | Descriptor: | Glyoxalase family protein, MANGANESE (II) ION, [(1S,2S)-1,2-DIHYDROXYPROPYL]PHOSPHONIC ACID | Authors: | Fillgrove, K.L, Pakhomova, S, Schaab, M, Newcomer, M.E, Armstrong, R.N. | Deposit date: | 2007-03-20 | Release date: | 2007-07-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure and Mechanism of the Genomically Encoded Fosfomycin Resistance Protein, FosX, from Listeria monocytogenes. Biochemistry, 46, 2007
|
|
2P7O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2p7o by Molmil](/molmil-images/mine/2p7o) | Crystal structure of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes (tetragonal form) | Descriptor: | Glyoxalase family protein, MANGANESE (II) ION | Authors: | Fillgrove, K.L, Pakhomova, S, Schaab, M, Newcomer, M.E, Armstrong, R.N. | Deposit date: | 2007-03-20 | Release date: | 2007-07-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Structure and Mechanism of the Genomically Encoded Fosfomycin Resistance Protein, FosX, from Listeria monocytogenes. Biochemistry, 46, 2007
|
|
2AZT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2azt by Molmil](/molmil-images/mine/2azt) | Crystal structure of H176N mutant of human Glycine N-Methyltransferase | Descriptor: | BETA-MERCAPTOETHANOL, CHLORIDE ION, CITRIC ACID, ... | Authors: | Luka, Z, Pakhomova, S, Luka, Y, Newcomer, M.E, Wagner, C. | Deposit date: | 2005-09-12 | Release date: | 2006-09-26 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Destabilization of human glycine N-methyltransferase by H176N mutation. Protein Sci., 16, 2007
|
|
2BAY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2bay by Molmil](/molmil-images/mine/2bay) | Crystal structure of the Prp19 U-box dimer | Descriptor: | Pre-mRNA splicing factor PRP19 | Authors: | Vander Kooi, C.W, Ohi, M.D, Rosenberg, J.A, Oldham, M.L, Newcomer, M.E, Gould, K.L, Chazin, W.J. | Deposit date: | 2005-10-15 | Release date: | 2006-01-10 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The Prp19 U-box Crystal Structure Suggests a Common Dimeric Architecture for a Class of Oligomeric E3 Ubiquitin Ligases. Biochemistry, 45, 2006
|
|
4KUM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4kum by Molmil](/molmil-images/mine/4kum) | Structure of LSD1-CoREST-Tetrahydrofolate complex | Descriptor: | (6S)-5,6,7,8-TETRAHYDROFOLATE, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Luka, Z, Pakhomova, S, Loukachevitch, L.V, Calcutt, M.W, Newcomer, M.E, Wagner, C. | Deposit date: | 2013-05-22 | Release date: | 2014-05-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Crystal structure of the histone lysine specific demethylase LSD1 complexed with tetrahydrofolate. Protein Sci., 23, 2014
|
|
4J03
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4j03 by Molmil](/molmil-images/mine/4j03) | Crystal structure of human soluble epoxide hydrolase complexed with fulvestrant | Descriptor: | (7beta,9beta,13alpha,17beta)-7-{9-[(R)-(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1(10),2,4-triene-3,17-diol, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ... | Authors: | Morisseau, C, Pakhomova, S, Hwang, S.H, Newcomer, M.E, Hammock, B.D. | Deposit date: | 2013-01-30 | Release date: | 2013-06-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides. Bioorg.Med.Chem.Lett., 23, 2013
|
|
3FG1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3fg1 by Molmil](/molmil-images/mine/3fg1) | Crystal structure of Delta413-417:GS LOX | Descriptor: | ACETIC ACID, Allene oxide synthase-lipoxygenase protein, CALCIUM ION, ... | Authors: | Neau, D.B, Newcomer, M.E. | Deposit date: | 2008-12-04 | Release date: | 2009-08-18 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity. Biochemistry, 48, 2009
|
|
3FG4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3fg4 by Molmil](/molmil-images/mine/3fg4) | Crystal structure of Delta413-417:GS I805A LOX | Descriptor: | ACETIC ACID, ARACHIDONIC ACID, Allene oxide synthase-lipoxygenase protein, ... | Authors: | Neau, D.B, Newcomer, M.E. | Deposit date: | 2008-12-04 | Release date: | 2009-08-18 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity. Biochemistry, 48, 2009
|
|
3FG3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3fg3 by Molmil](/molmil-images/mine/3fg3) | Crystal structure of Delta413-417:GS I805W LOX | Descriptor: | ACETIC ACID, Allene oxide synthase-lipoxygenase protein, CALCIUM ION, ... | Authors: | Neau, D.B, Newcomer, M.E. | Deposit date: | 2008-12-04 | Release date: | 2009-08-18 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity. Biochemistry, 48, 2009
|
|
5UYT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5uyt by Molmil](/molmil-images/mine/5uyt) | Crystal structure of ice binding protein from an Antarctic bacterium Flavobacteriaceae | Descriptor: | Ice-binding protein, NITRATE ION | Authors: | Wang, C, Pakhomova, S, Newcomer, M.E, Christner, B.C, Luo, B.-H. | Deposit date: | 2017-02-24 | Release date: | 2017-10-25 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural basis of antifreeze activity of a bacterial multi-domain antifreeze protein. PLoS ONE, 12, 2017
|
|
4HAI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4hai by Molmil](/molmil-images/mine/4hai) | Crystal structure of human soluble epoxide hydrolase complexed with N-cycloheptyl-1-(mesitylsulfonyl)piperidine-4-carboxamide. | Descriptor: | Bifunctional epoxide hydrolase 2, MAGNESIUM ION, N-cycloheptyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide, ... | Authors: | Pecic, S, Pakhomova, S, Newcomer, M.E, Morisseau, C, Hammock, B.D, Zhu, Z, Deng, S. | Deposit date: | 2012-09-26 | Release date: | 2012-12-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
|
|
2P7M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2p7m by Molmil](/molmil-images/mine/2p7m) | Crystal structure of monoclinic form of genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenes at pH 6.5 | Descriptor: | Glyoxalase family protein | Authors: | Fillgrove, K.L, Pakhomova, S, Schaab, M, Newcomer, M.E, Armstrong, R.N. | Deposit date: | 2007-03-20 | Release date: | 2007-07-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure and Mechanism of the Genomically Encoded Fosfomycin Resistance Protein, FosX, from Listeria monocytogenes. Biochemistry, 46, 2007
|
|