2FFL
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![BU of 2ffl by Molmil](/molmil-images/mine/2ffl) | |
2QVW
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4OGC
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![BU of 4ogc by Molmil](/molmil-images/mine/4ogc) | Crystal structure of the Type II-C Cas9 enzyme from Actinomyces naeslundii | Descriptor: | ACETATE ION, HNH endonuclease domain protein, MAGNESIUM ION, ... | Authors: | Jiang, F, Ma, E, Lin, S, Doudna, J.A. | Deposit date: | 2014-01-15 | Release date: | 2014-02-12 | Last modified: | 2014-03-26 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structures of Cas9 endonucleases reveal RNA-mediated conformational activation. Science, 343, 2014
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4OGE
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![BU of 4oge by Molmil](/molmil-images/mine/4oge) | Crystal structure of the Type II-C Cas9 enzyme from Actinomyces naeslundii | Descriptor: | HNH endonuclease domain protein, MAGNESIUM ION, SPERMIDINE, ... | Authors: | Jiang, F, Ma, E, Lin, S, Doudna, J.A. | Deposit date: | 2014-01-15 | Release date: | 2014-02-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.201 Å) | Cite: | Structures of Cas9 endonucleases reveal RNA-mediated conformational activation. Science, 343, 2014
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5VGB
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![BU of 5vgb by Molmil](/molmil-images/mine/5vgb) | Crystal structure of NmeCas9 HNH domain bound to anti-CRISPR AcrIIC1 | Descriptor: | Anti-CRISPR protein (AcrIIC1), CRISPR-associated endonuclease Cas9, GLYCEROL, ... | Authors: | Harrington, L.B, Doxzen, K.W, Ma, E, Knott, G.J, Kranzusch, P.J, Doudna, J.A. | Deposit date: | 2017-04-10 | Release date: | 2017-08-30 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.497 Å) | Cite: | A Broad-Spectrum Inhibitor of CRISPR-Cas9. Cell, 170, 2017
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5VVL
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![BU of 5vvl by Molmil](/molmil-images/mine/5vvl) | Cas1-Cas2 bound to full-site mimic with Ni | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (11-MER), ... | Authors: | Wright, A.V, Knott, G.J, Doxzen, K.D, Doudna, J.A. | Deposit date: | 2017-05-19 | Release date: | 2017-08-02 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.31 Å) | Cite: | Structures of the CRISPR genome integration complex. Science, 357, 2017
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5VZL
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![BU of 5vzl by Molmil](/molmil-images/mine/5vzl) | cryo-EM structure of the Cas9-sgRNA-AcrIIA4 anti-CRISPR complex | Descriptor: | CRISPR-associated endonuclease Cas9, phage anti-CRISPR AcrIIA4, single guide RNA (116-MER) | Authors: | Jiang, F, Liu, J.J, Nogales, E, Doudna, J.A. | Deposit date: | 2017-05-29 | Release date: | 2017-07-26 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Disabling Cas9 by an anti-CRISPR DNA mimic. Sci Adv, 3, 2017
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8VXY
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![BU of 8vxy by Molmil](/molmil-images/mine/8vxy) | Structure of HamA(E138A,K140A)B-plasmid DNA complex from the Escherichia coli Hachiman defense system | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, HamA, HamB, ... | Authors: | Tuck, O.T, Hu, J.J, Doudna, J.A. | Deposit date: | 2024-02-06 | Release date: | 2024-03-13 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Hachiman is a genome integrity sensor. Biorxiv, 2024
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8VXA
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8VXC
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![BU of 8vxc by Molmil](/molmil-images/mine/8vxc) | |
8VX9
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4TY0
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![BU of 4ty0 by Molmil](/molmil-images/mine/4ty0) | Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase in complex with linear intermediate 5' pppA(3',5')pG | Descriptor: | ACETATE ION, Cyclic AMP-GMP synthase, MAGNESIUM ION, ... | Authors: | Kranzusch, P.J, Lee, A.S.Y, Wilson, S.C, Solovykh, M.S, Vance, R.E, Berger, J.M, Doudna, J.A. | Deposit date: | 2014-07-07 | Release date: | 2014-08-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity. Cell, 158, 2014
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4TXZ
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![BU of 4txz by Molmil](/molmil-images/mine/4txz) | Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase in complex with nonhydrolyzable GTP | Descriptor: | Cyclic AMP-GMP synthase, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER | Authors: | Kranzusch, P.J, Lee, A.S.Y, Wilson, S.C, Solovykh, M.S, Vance, R.E, Berger, J.M, Doudna, J.A. | Deposit date: | 2014-07-07 | Release date: | 2014-08-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity. Cell, 158, 2014
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4WYQ
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![BU of 4wyq by Molmil](/molmil-images/mine/4wyq) | Crystal structure of the Dicer-TRBP interface | Descriptor: | Endoribonuclease Dicer, Poly(UNK), RISC-loading complex subunit TARBP2 | Authors: | Wilson, R.C, Doudna, J.A. | Deposit date: | 2014-11-18 | Release date: | 2014-12-17 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Dicer-TRBP Complex Formation Ensures Accurate Mammalian MicroRNA Biogenesis. Mol.Cell, 57, 2015
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5WFE
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![BU of 5wfe by Molmil](/molmil-images/mine/5wfe) | Cas1-Cas2-IHF-DNA holo-complex | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ... | Authors: | Wright, A.V, Liu, J.J, Nogales, E, Doudna, J.A. | Deposit date: | 2017-07-11 | Release date: | 2017-08-02 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.64 Å) | Cite: | Structures of the CRISPR genome integration complex. Science, 357, 2017
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5WLH
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![BU of 5wlh by Molmil](/molmil-images/mine/5wlh) | |
5W1H
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5VVK
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![BU of 5vvk by Molmil](/molmil-images/mine/5vvk) | Cas1-Cas2 bound to full-site mimic | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (5'-D(*GP*AP*CP*CP*AP*CP*CP*AP*GP*TP*G)-3'), ... | Authors: | Wright, A.V, Knott, G.J, Doxzen, K.D, Doudna, J.A. | Deposit date: | 2017-05-19 | Release date: | 2017-08-02 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structures of the CRISPR genome integration complex. Science, 357, 2017
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5VVJ
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![BU of 5vvj by Molmil](/molmil-images/mine/5vvj) | Cas1-Cas2 bound to half-site intermediate | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (112-MER), ... | Authors: | Wright, A.V, Knott, G.J, Doxzen, K.W, Doudna, J.A. | Deposit date: | 2017-05-19 | Release date: | 2017-08-02 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.89 Å) | Cite: | Structures of the CRISPR genome integration complex. Science, 357, 2017
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5W1I
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8UZB
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![BU of 8uzb by Molmil](/molmil-images/mine/8uzb) | Cryo-EM structure of iGeoCas9 in complex with sgRNA and target DNA | Descriptor: | CRISPR-associated endonuclease Cas9, Non-target strand DNA, RNA (107-MER), ... | Authors: | Eggers, A.R, Soczek, K.M, Tuck, O.T, Doudna, J.A. | Deposit date: | 2023-11-14 | Release date: | 2024-05-29 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.63 Å) | Cite: | Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9. Cell, 187, 2024
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8UZA
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![BU of 8uza by Molmil](/molmil-images/mine/8uza) | Cryo-EM structure of GeoCas9 in complex with sgRNA and target DNA | Descriptor: | CRISPR-associated endonuclease Cas9, Non-target strand DNA, Target strand DNA, ... | Authors: | Eggers, A.R, Soczek, K.M, Tuck, O.T, Doudna, J.A. | Deposit date: | 2023-11-14 | Release date: | 2024-05-29 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9. Cell, 187, 2024
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1GID
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![BU of 1gid by Molmil](/molmil-images/mine/1gid) | CRYSTAL STRUCTURE OF A GROUP I RIBOZYME DOMAIN: PRINCIPLES OF RNA PACKING | Descriptor: | COBALT HEXAMMINE(III), MAGNESIUM ION, P4-P6 RNA RIBOZYME DOMAIN | Authors: | Cate, J.H, Gooding, A.R, Podell, E, Zhou, K, Golden, B.L, Kundrot, C.E, Cech, T.R, Doudna, J.A. | Deposit date: | 1996-08-22 | Release date: | 1996-12-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of a group I ribozyme domain: principles of RNA packing. Science, 273, 1996
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6VPC
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![BU of 6vpc by Molmil](/molmil-images/mine/6vpc) | Structure of the SpCas9 DNA adenine base editor - ABE8e | Descriptor: | CRISPR-associated endonuclease Cas9, Cas9 (SpCas9) single-guide RNA (sgRNA), DNA non-target strand (NTS), ... | Authors: | Knott, G.J, Lapinaite, A, Doudna, J.A. | Deposit date: | 2020-02-03 | Release date: | 2020-07-29 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | DNA capture by a CRISPR-Cas9-guided adenine base editor. Science, 369, 2020
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2X04
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![BU of 2x04 by Molmil](/molmil-images/mine/2x04) | Crystal structure of the PABC-TNRC6C complex | Descriptor: | POLYADENYLATE-BINDING PROTEIN 1, SULFATE ION, TRINUCLEOTIDE REPEAT-CONTAINING GENE 6C PROTEIN | Authors: | Jinek, M, Fabian, M.R, Coyle, S.M, Sonenberg, N, Doudna, J.A. | Deposit date: | 2009-12-04 | Release date: | 2010-01-19 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Structural Insights Into the Human Gw182-Pabc Interaction in Microrna-Mediated Deadenylation Nat.Struct.Mol.Biol., 17, 2010
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