7VMU
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![BU of 7vmu by Molmil](/molmil-images/mine/7vmu) | Crystal Structure of SARS-CoV Spike Receptor-Binding Domain Complexed with Neutralizing Antibody | Descriptor: | Spike protein S1, scFv E4 | Authors: | Guo, Y, Wang, W, Jiao, P, Yang, H, Rao, Z, Cheng, G. | Deposit date: | 2021-10-09 | Release date: | 2021-11-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants. Cell Biosci, 12, 2022
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1D9S
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![BU of 1d9s by Molmil](/molmil-images/mine/1d9s) | TUMOR SUPPRESSOR P15(INK4B) STRUCTURE BY COMPARATIVE MODELING AND NMR DATA | Descriptor: | CYCLIN-DEPENDENT KINASE 4 INHIBITOR B | Authors: | Yuan, C, Ji, L, Selby, T.L, Byeon, I.J.L, Tsai, M.D. | Deposit date: | 1999-10-29 | Release date: | 2000-07-28 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Tumor suppressor INK4: comparisons of conformational properties between p16(INK4A) and p18(INK4C). J.Mol.Biol., 294, 1999
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5X74
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![BU of 5x74 by Molmil](/molmil-images/mine/5x74) | The crystal Structure PDE delta in complex with compound (R, R)-1g | Descriptor: | (2R)-2-(2-fluorophenyl)-3-[2-[4-[(2R)-2-(2-fluorophenyl)-4-oxidanylidene-1,2-dihydroquinazolin-3-yl]piperidin-1-yl]ethyl]-1,2-dihydroquinazolin-4-one, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | Authors: | Jiang, Y, Zhuang, C, Chen, L, Wang, R, Wang, F, Sheng, C. | Deposit date: | 2017-02-23 | Release date: | 2017-10-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural Biology-Inspired Discovery of Novel KRAS-PDE delta Inhibitors J. Med. Chem., 60, 2017
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5X73
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![BU of 5x73 by Molmil](/molmil-images/mine/5x73) | The crystal Structure PDE delta in complex with R-p9 | Descriptor: | (2R)-2-(2-fluorophenyl)-3-phenyl-1,2-dihydroquinazolin-4-one, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | Authors: | Jiang, Y, Zhuang, C, Chen, L, Wang, R, Wang, F, Sheng, C. | Deposit date: | 2017-02-23 | Release date: | 2017-10-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Biology-Inspired Discovery of Novel KRAS-PDE delta Inhibitors J. Med. Chem., 60, 2017
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6LPV
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![BU of 6lpv by Molmil](/molmil-images/mine/6lpv) | |
4EYA
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![BU of 4eya by Molmil](/molmil-images/mine/4eya) | Crystal Structure of a Plectonemic RNA Supercoil | Descriptor: | GLYCEROL, N utilization substance protein B homolog, RNA (5'-R(*GP*GP*CP*UP*CP*CP*UP*UP*GP*GP*CP*A)-3'), ... | Authors: | Stagno, J.R, Ji, X. | Deposit date: | 2012-05-01 | Release date: | 2012-06-20 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure of a plectonemic RNA supercoil. Nat Commun, 3, 2012
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6MX5
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![BU of 6mx5 by Molmil](/molmil-images/mine/6mx5) | |
6N8S
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6N8R
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![BU of 6n8r by Molmil](/molmil-images/mine/6n8r) | |
6N8Q
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![BU of 6n8q by Molmil](/molmil-images/mine/6n8q) | |
5YFG
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![BU of 5yfg by Molmil](/molmil-images/mine/5yfg) | SOLUTION STRUCTURE OF HUMAN MOG1 | Descriptor: | Ran guanine nucleotide release factor | Authors: | Hu, Q, Liu, Y, Bao, X, Liu, H. | Deposit date: | 2017-09-21 | Release date: | 2017-11-01 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation J Mol Cell Biol, 10, 2018
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1OIA
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![BU of 1oia by Molmil](/molmil-images/mine/1oia) | U1A rnp domain 1-95 | Descriptor: | U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A | Authors: | Nagai, K, Evans, P.R. | Deposit date: | 2003-06-12 | Release date: | 2003-06-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure of the RNA-Binding Domain of the U1 Small Nuclear Ribonucleoprotein A Nature, 348, 1990
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7LMX
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![BU of 7lmx by Molmil](/molmil-images/mine/7lmx) | A HIGHLY SPECIFIC INHIBITOR OF INTEGRIN ALPHA-V BETA-6 WITH A DISULFIDE | Descriptor: | Integrin inhibitor | Authors: | Dong, X, Bera, A.K, Roy, A, Shi, L, Springer, T.A, Baker, D. | Deposit date: | 2021-02-06 | Release date: | 2022-08-10 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8. Nat Commun, 14, 2023
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7LMV
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![BU of 7lmv by Molmil](/molmil-images/mine/7lmv) | SPECIFIC INHIBITOR OF INTEGRIN ALPHA-V BETA-6 | Descriptor: | Integrin inhibitor | Authors: | Dong, X, Bera, A.K, Roy, A, Shi, L, Springer, T.A, Baker, D. | Deposit date: | 2021-02-05 | Release date: | 2022-08-10 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8. Nat Commun, 14, 2023
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5X72
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![BU of 5x72 by Molmil](/molmil-images/mine/5x72) | The crystal Structure PDE delta in complex with (rac)-p9 | Descriptor: | (2R)-2-(2-fluorophenyl)-3-phenyl-1,2-dihydroquinazolin-4-one, (2S)-2-(2-fluorophenyl)-3-phenyl-1,2-dihydroquinazolin-4-one, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | Authors: | Jiang, Y, Zhuang, C, Chen, L, Wang, R, Wang, F, Sheng, C. | Deposit date: | 2017-02-23 | Release date: | 2017-10-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural Biology-Inspired Discovery of Novel KRAS-PDE delta Inhibitors J. Med. Chem., 60, 2017
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6N8P
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![BU of 6n8p by Molmil](/molmil-images/mine/6n8p) | |
7ELY
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![BU of 7ely by Molmil](/molmil-images/mine/7ely) | |
7JG3
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![BU of 7jg3 by Molmil](/molmil-images/mine/7jg3) | Human GAR transformylase in complex with GAR substrate and AGF103 inhibitor | Descriptor: | GLYCINAMIDE RIBONUCLEOTIDE, N-{5-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]furan-2-carbonyl}-L-glutamic acid, SODIUM ION, ... | Authors: | Wong-Roushar, J, Dann III, C.E. | Deposit date: | 2020-07-18 | Release date: | 2021-03-31 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.091 Å) | Cite: | Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors Bioorg.Med.Chem., 37, 2021
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7JG4
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![BU of 7jg4 by Molmil](/molmil-images/mine/7jg4) | Human GAR transformylase in complex with GAR substrate and AGF131 inhibitor | Descriptor: | GLYCINAMIDE RIBONUCLEOTIDE, N-(5-{3-[(1S,7R,8R,9S)-4-amino-2-oxo-7lambda~4~-thia-3,5-diazatetracyclo[4.3.0.0~1,7~.0~7,9~]nona-3,5-dien-8-yl]propyl}thiophene-2-carbonyl)-L-glutamic acid, SODIUM ION, ... | Authors: | Wong-Roushar, J, Dann III, C.E. | Deposit date: | 2020-07-18 | Release date: | 2021-03-31 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.455 Å) | Cite: | Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors Bioorg.Med.Chem., 37, 2021
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7JG0
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![BU of 7jg0 by Molmil](/molmil-images/mine/7jg0) | Human GAR transformylase in complex with GAR substrate and AGF102 inhibitor | Descriptor: | GLYCINAMIDE RIBONUCLEOTIDE, N-{5-[4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]thiophene-2-carbonyl}-L-glutamic acid, Trifunctional purine biosynthetic protein adenosine-3 | Authors: | Wong-Roushar, J, Dann III, C.E. | Deposit date: | 2020-07-18 | Release date: | 2021-03-31 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.984 Å) | Cite: | Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors Bioorg.Med.Chem., 37, 2021
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7K93
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![BU of 7k93 by Molmil](/molmil-images/mine/7k93) | |
6O3E
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![BU of 6o3e by Molmil](/molmil-images/mine/6o3e) | mouse aE-catenin 82-883 | Descriptor: | Catenin alpha-1 | Authors: | Pokutta, S, Weis, W.I. | Deposit date: | 2019-02-26 | Release date: | 2019-11-13 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (4.001 Å) | Cite: | Binding partner- and force-promoted changes in alpha E-catenin conformation probed by native cysteine labeling. Sci Rep, 9, 2019
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5EJN
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7E1L
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![BU of 7e1l by Molmil](/molmil-images/mine/7e1l) | Crystal structure of apo form PhlH | Descriptor: | DUF1956 domain-containing protein | Authors: | Zhang, N, Wu, J, He, Y.X, Ge, H. | Deposit date: | 2021-02-01 | Release date: | 2022-02-02 | Last modified: | 2022-08-24 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Molecular basis for coordinating secondary metabolite production by bacterial and plant signaling molecules. J.Biol.Chem., 298, 2022
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7E1N
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![BU of 7e1n by Molmil](/molmil-images/mine/7e1n) | Crystal structure of PhlH in complex with 2,4-diacetylphloroglucinol | Descriptor: | 2,4-bis[(1R)-1-oxidanylethyl]benzene-1,3,5-triol, DUF1956 domain-containing protein | Authors: | Zhang, N, Wu, J, He, Y.X, Ge, H. | Deposit date: | 2021-02-02 | Release date: | 2022-02-02 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular basis for coordinating secondary metabolite production by bacterial and plant signaling molecules. J.Biol.Chem., 298, 2022
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