5X74
The crystal Structure PDE delta in complex with compound (R, R)-1g
Summary for 5X74
Entry DOI | 10.2210/pdb5x74/pdb |
Related | 5X72 5X73 |
Descriptor | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, (2R)-2-(2-fluorophenyl)-3-[2-[4-[(2R)-2-(2-fluorophenyl)-4-oxidanylidene-1,2-dihydroquinazolin-3-yl]piperidin-1-yl]ethyl]-1,2-dihydroquinazolin-4-one (3 entities in total) |
Functional Keywords | lipid binding protein |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytosol : O43924 |
Total number of polymer chains | 1 |
Total formula weight | 17992.62 |
Authors | |
Primary citation | Jiang, Y.,Zhuang, C.,Chen, L.,Lu, J.,Dong, G.,Miao, Z.,Zhang, W.,Li, J.,Sheng, C. Structural Biology-Inspired Discovery of Novel KRAS-PDE delta Inhibitors J. Med. Chem., 60:9400-9406, 2017 Cited by PubMed: 28929751DOI: 10.1021/acs.jmedchem.7b01243 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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