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7AYY
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BU of 7ayy by Molmil
Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with activator TH10785
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, N-glycosylase/DNA lyase, ...
Authors:Masuyer, G, Davies, J.R, Stenmark, P.
Deposit date:2020-11-13
Release date:2022-06-01
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.
Science, 376, 2022
2J2C
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BU of 2j2c by Molmil
Crystal structure of Human Cytosolic 5'-Nucleotidase II (NT5C2, cN-II)
Descriptor: CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, MAGNESIUM ION, ...
Authors:Wallden, K, Stenmark, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg Schiavone, L, Hogbom, M, Karlberg, T, Kotenyova, T, Loppnau, P, Magnusdottir, A, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Welin, M, Nordlund, P.
Deposit date:2006-08-16
Release date:2006-09-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of Human Cytosolic 5'- Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition
J.Biol.Chem., 282, 2007
2JCM
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BU of 2jcm by Molmil
Crystal structure of Human Cytosolic 5'-Nucleotidase II in complex with beryllium trifluoride
Descriptor: CYTOSOLIC PURINE 5'-NUCLEOTIDASE, MAGNESIUM ION, SULFATE ION, ...
Authors:Wallden, K, Stenmark, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg Schiavone, L, Hogbom, M, Karlberg, T, Kotenyova, T, Magnusdottir, A, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Thorsell, A.G, Van Den Berg, S, Loppnau, P, Weigelt, J, Welin, M, Nordlund, P.
Deposit date:2006-12-27
Release date:2007-01-30
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal Structure of Human Cytosolic 5'- Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition
J.Biol.Chem., 282, 2007
2JC9
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BU of 2jc9 by Molmil
Crystal structure of Human Cytosolic 5'-Nucleotidase II in complex with adenosine
Descriptor: ADENOSINE, CYTOSOLIC PURINE 5'-NUCLEOTIDASE, GLYCEROL, ...
Authors:Wallden, K, Stenmark, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmberg, S.L, Hogbom, M, Karlberg, T, Kotenyova, T, Magnusdottir, A, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Thorsell, A.G, Van Den Berg, S, Loppnau, P, Weigelt, J, Welin, M, Nordlund, P.
Deposit date:2006-12-21
Release date:2007-01-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of Human Cytosolic 5'-Nucleotidase II: Insights Into Allosteric Regulation and Substrate Recognition
J.Biol.Chem., 282, 2007
2GK9
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BU of 2gk9 by Molmil
Human Phosphatidylinositol-4-phosphate 5-kinase, type II, gamma
Descriptor: phosphatidylinositol-4-phosphate 5-kinase, type II, gamma
Authors:Uppenberg, J, Hogbom, M, Ogg, D, Arrowsmith, C, Berglund, H, Collins, R, Ehn, M, Flodin, S, Flores, A, Graslund, S, Holmberg-Schiavone, L, Edwards, A, Hammarstrom, M, Kotenyova, T, Nilsson-Ehle, P, Nordlund, P, Nyman, T, Persson, C, Sagemark, J, Stenmark, P, Sundstrom, M, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Hallberg, B.M, Structural Genomics Consortium (SGC)
Deposit date:2006-03-31
Release date:2006-05-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of Human Phosphatidylinositol-4-phosphate 5-kinase, type II, gamma
To be Published
6EHH
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BU of 6ehh by Molmil
Crystal structure of mouse MTH1 mutant L116M with inhibitor TH588
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, COPPER (II) ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Gustafsson, R, Narwal, M, Jemth, A.-S, Almlof, I, Warpman Berglund, U, Helleday, T, Stenmark, P.
Deposit date:2017-09-13
Release date:2018-01-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.
Biochemistry, 57, 2018
6RIM
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BU of 6rim by Molmil
Crystal structure of the catalytic domain of the Weissela oryzae botulinum like toxin
Descriptor: CALCIUM ION, Putative botulinum-like toxin Wo, ZINC ION
Authors:Kosenina, S, Masuyer, G, Stenmark, P.
Deposit date:2019-04-24
Release date:2019-05-29
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of the catalytic domain of the Weissella oryzae botulinum-like toxin.
Febs Lett., 593, 2019
6ES1
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BU of 6es1 by Molmil
Crystal structure of the binding domain from botulinum neurotoxin A2 bound to extracellular domain of human receptor SV2C
Descriptor: ACETATE ION, Botulinum neurotoxin type A, Synaptic vesicle glycoprotein 2C
Authors:Gustafsson, R, Masuyer, G, Stenmark, P.
Deposit date:2017-10-19
Release date:2018-04-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding.
Toxins (Basel), 10, 2018
6RWT
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BU of 6rwt by Molmil
Crystal structure of the Cbp3 homolog from Brucella abortus
Descriptor: ACETATE ION, GLYCEROL, MAGNESIUM ION, ...
Authors:Masuyer, G, Ndi, M, Ott, M, Stenmark, P.
Deposit date:2019-06-06
Release date:2019-09-18
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Structural basis for the interaction of the chaperone Cbp3 with newly synthesized cytochromebduring mitochondrial respiratory chain assembly.
J.Biol.Chem., 294, 2019
5MZF
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BU of 5mzf by Molmil
Crystal structure of dog MTH1 protein
Descriptor: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
Authors:Narwal, M, Jemth, A.-S, Helleday, T, Stenmark, P.
Deposit date:2017-01-31
Release date:2018-01-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.
Biochemistry, 57, 2018
5N0C
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BU of 5n0c by Molmil
Crystal structure of the tetanus neurotoxin in complex with GM1a
Descriptor: DI(HYDROXYETHYL)ETHER, Tetanus toxin, ZINC ION, ...
Authors:Masuyer, G, Conrad, J, Stenmark, P.
Deposit date:2017-02-02
Release date:2017-06-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structure of the tetanus toxin reveals pH-mediated domain dynamics.
EMBO Rep., 18, 2017
5MZG
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BU of 5mzg by Molmil
Crystal structure of mouse MTH1 in complex with TH588
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, N~4~-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine, SULFATE ION, ...
Authors:Narwal, M, Jemth, A.-S, Helleday, T, Stenmark, P.
Deposit date:2017-01-31
Release date:2018-01-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.
Biochemistry, 57, 2018
6F4E
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BU of 6f4e by Molmil
Crystal structure of the zinc-free catalytic domain of botulinum neurotoxin X
Descriptor: Catalytic domain of botulinum neurotoxin X, DI(HYDROXYETHYL)ETHER
Authors:Masuyer, G, Henriksson, L, Kosenina, S, Zhang, S, Barkho, S, Shen, Y, Dong, M, Stenmark, P.
Deposit date:2017-11-29
Release date:2018-03-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity.
Sci Rep, 8, 2018
5NGR
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BU of 5ngr by Molmil
Crystal structure of human MTH1 in complex with fragment inhibitor 8-(methylsulfanyl)-7H-purin-6-amine
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, 8-methylsulfanyl-7~{H}-purin-6-amine, SULFATE ION
Authors:Gustafsson, R, Rudling, A, Almlof, I, Homan, E, Scobie, M, Warpman Berglund, U, Helleday, T, Carlsson, J, Stenmark, P.
Deposit date:2017-03-20
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space.
J. Med. Chem., 60, 2017
5NGS
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BU of 5ngs by Molmil
Crystal structure of human MTH1 in complex with inhibitor 6-[(2-phenylethyl)sulfanyl]-7H-purin-2-amine
Descriptor: 6-(2-phenylethylsulfanyl)-7~{H}-purin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, ACETATE ION, ...
Authors:Gustafsson, R, Rudling, A, Almlof, I, Homan, E, Scobie, M, Warpman Berglund, U, Helleday, T, Carlsson, J, Stenmark, P.
Deposit date:2017-03-20
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space.
J. Med. Chem., 60, 2017
6SQW
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BU of 6sqw by Molmil
Mouse dCTPase in complex with 5-Me-dCMP
Descriptor: 5-METHYL-2'-DEOXY-CYTIDINE-5'-MONOPHOSPHATE, MAGNESIUM ION, dCTP pyrophosphatase 1
Authors:Scaletti, E.R, Claesson, M, Helleday, H, Jemth, A.S, Stenmark, P.
Deposit date:2019-09-04
Release date:2020-01-29
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products.
J.Mol.Biol., 432, 2020
6F47
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BU of 6f47 by Molmil
Crystal structure of the catalytic domain of botulinum neurotoxin X
Descriptor: Catalytic domain of botulinum neurotoxin X, ZINC ION
Authors:Masuyer, G, Henriksson, L, Kosenina, S, Zhang, S, Barkho, S, Shen, Y, Dong, M, Stenmark, P.
Deposit date:2017-11-29
Release date:2018-03-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity.
Sci Rep, 8, 2018
5NGT
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BU of 5ngt by Molmil
Crystal structure of human MTH1 in complex with inhibitor 7-(furan-2-yl)-5-methyl-1,3-benzoxazol-2-amine
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, 7-(furan-2-yl)-5-methyl-1,3-benzoxazol-2-amine, SULFATE ION
Authors:Gustafsson, R, Rudling, A, Almlof, I, Homan, E, Scobie, M, Warpman Berglund, U, Helleday, T, Carlsson, J, Stenmark, P.
Deposit date:2017-03-20
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space.
J. Med. Chem., 60, 2017
6FL4
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BU of 6fl4 by Molmil
A. thaliana NUDT1 in complex with 8-oxo-dGTP
Descriptor: 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Nudix hydrolase 1
Authors:Jemth, A.S, Scaletti-Hutchinson, E, Carter, M, Helleday, T, Stenmark, P.
Deposit date:2018-01-25
Release date:2019-02-06
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana.
Biochemistry, 58, 2019
6SQZ
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BU of 6sqz by Molmil
Mouse dCTPase in complex with dCMPNPP
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidine, MAGNESIUM ION, dCTP pyrophosphatase 1
Authors:Scaletti, E.R, Claesson, M, Helleday, H, Jemth, A.S, Stenmark, P.
Deposit date:2019-09-04
Release date:2020-01-29
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products.
J.Mol.Biol., 432, 2020
5MZE
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BU of 5mze by Molmil
Crystal structure of mouse MTH1 with 8-oxo-dGTP
Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, 8-OXO-2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, COPPER (II) ION, ...
Authors:Narwal, M, Jemth, A.-S, Helleday, T, Stenmark, P.
Deposit date:2017-01-31
Release date:2018-01-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.
Biochemistry, 57, 2018
6FLS
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BU of 6fls by Molmil
Pentapeptide repeat family protein from Clostridium botulinum
Descriptor: GLYCEROL, Pentapeptide repeat family protein
Authors:Martinez-Carranza, M, Stenmark, P.
Deposit date:2018-01-27
Release date:2018-08-15
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Cotranslational Folding of a Pentarepeat beta-Helix Protein.
J. Mol. Biol., 430, 2018
5N0B
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BU of 5n0b by Molmil
Crystal structure of the tetanus neurotoxin in complex with GD1a
Descriptor: DI(HYDROXYETHYL)ETHER, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, Tetanus toxin, ...
Authors:Masuyer, G, Conrad, J, Stenmark, P.
Deposit date:2017-02-02
Release date:2017-06-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structure of the tetanus toxin reveals pH-mediated domain dynamics.
EMBO Rep., 18, 2017
5LV0
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BU of 5lv0 by Molmil
Structure of Human Neurolysin (E475Q) in complex with amyloid-beta 35-40 peptide product
Descriptor: CHLORIDE ION, GLY-VAL-VAL amyloid 35-40 fragment, Neurolysin, ...
Authors:Masuyer, G, Berntsson, R.P.-A, Teixeira, P.F, Kmiec, B, Glaser, E, Stenmark, P.
Deposit date:2016-09-12
Release date:2017-12-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and functional analysis of Neurolysin, a new component of the mitochondrial peptidolytic network
To Be Published
6T2T
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BU of 6t2t by Molmil
Crystal structure of Drosophila melanogaster glutathione S-transferase epsilon 14 in complex with glutathione and 2-methyl-2,4-pentanediol
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, GLUTATHIONE, Glutathione S-transferase E14
Authors:Skerlova, J, Lindstrom, H, Sjodin, B, Gonis, E, Neiers, F, Mannervik, B, Stenmark, P.
Deposit date:2019-10-09
Release date:2020-01-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure and steroid isomerase activity of Drosophila glutathione transferase E14 essential for ecdysteroid biosynthesis.
Febs Lett., 594, 2020

221051

數據於2024-06-12公開中

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