6QVO

Crystal structure of human MTH1 in complex with N6-methyl-dAMP

Summary for 6QVO

Entry DOI	10.2210/pdb6qvo/pdb
Descriptor	7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION, N6-METHYL-DEOXY-ADENOSINE-5'-MONOPHOSPHATE, ... (5 entities in total)
Functional Keywords	----, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	92223.73
Authors	Scaletti, E.,Vallin, K.S.,Brautigam, L.,Sarno, A.,Warpman Berglund, U.,Helleday, T.,Stenmark, P.,Jemth, A.S. (deposition date: 2019-03-04, release date: 2020-03-18, Last modification date: 2020-09-30)
Primary citation	Scaletti, E.R.,Vallin, K.S.,Brautigam, L.,Sarno, A.,Warpman Berglund, U.,Helleday, T.,Stenmark, P.,Jemth, A.S. MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool. J.Biol.Chem., 295:4761-4772, 2020 Cited by PubMed: 32144205 DOI: 10.1074/jbc.RA120.012636 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation