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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6QVO

Crystal structure of human MTH1 in complex with N6-methyl-dAMP

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0006152biological_processpurine nucleoside catabolic process
A0006281biological_processDNA repair
A0006979biological_processresponse to oxidative stress
A0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
A0008828molecular_functiondATP diphosphatase activity
A0016787molecular_functionhydrolase activity
A0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
A0030515molecular_functionsnoRNA binding
A0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
A0042262biological_processDNA protection
A0046872molecular_functionmetal ion binding
A0047693molecular_functionATP diphosphatase activity
A0106377molecular_function2-hydroxy-ATP hydrolase activity
A0106378molecular_function2-hydroxy-dATP hydrolase activity
A0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
A0106433molecular_functionO6-methyl-dGTP hydrolase activity
A0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0006152biological_processpurine nucleoside catabolic process
B0006281biological_processDNA repair
B0006979biological_processresponse to oxidative stress
B0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
B0008828molecular_functiondATP diphosphatase activity
B0016787molecular_functionhydrolase activity
B0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
B0030515molecular_functionsnoRNA binding
B0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
B0042262biological_processDNA protection
B0046872molecular_functionmetal ion binding
B0047693molecular_functionATP diphosphatase activity
B0106377molecular_function2-hydroxy-ATP hydrolase activity
B0106378molecular_function2-hydroxy-dATP hydrolase activity
B0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
B0106433molecular_functionO6-methyl-dGTP hydrolase activity
B0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
C0003723molecular_functionRNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005759cellular_componentmitochondrial matrix
C0005829cellular_componentcytosol
C0006152biological_processpurine nucleoside catabolic process
C0006281biological_processDNA repair
C0006979biological_processresponse to oxidative stress
C0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
C0008828molecular_functiondATP diphosphatase activity
C0016787molecular_functionhydrolase activity
C0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
C0030515molecular_functionsnoRNA binding
C0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
C0042262biological_processDNA protection
C0046872molecular_functionmetal ion binding
C0047693molecular_functionATP diphosphatase activity
C0106377molecular_function2-hydroxy-ATP hydrolase activity
C0106378molecular_function2-hydroxy-dATP hydrolase activity
C0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
C0106433molecular_functionO6-methyl-dGTP hydrolase activity
C0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
D0003723molecular_functionRNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005759cellular_componentmitochondrial matrix
D0005829cellular_componentcytosol
D0006152biological_processpurine nucleoside catabolic process
D0006281biological_processDNA repair
D0006979biological_processresponse to oxidative stress
D0008413molecular_function8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
D0008828molecular_functiondATP diphosphatase activity
D0016787molecular_functionhydrolase activity
D0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
D0030515molecular_functionsnoRNA binding
D0035539molecular_function8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
D0042262biological_processDNA protection
D0046872molecular_functionmetal ion binding
D0047693molecular_functionATP diphosphatase activity
D0106377molecular_function2-hydroxy-ATP hydrolase activity
D0106378molecular_function2-hydroxy-dATP hydrolase activity
D0106431molecular_functionN6-methyl-(d)ATP hydrolase activity
D0106433molecular_functionO6-methyl-dGTP hydrolase activity
D0140933molecular_function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue SO4 A 201
ChainResidue
AALA63
AHIS65
ATHR88
AASP89
ASER90
site_idAC2
Number of Residues4
Detailsbinding site for residue SO4 A 202
ChainResidue
ATYR136
AASP147
BLYS24
BGLU97
site_idAC3
Number of Residues3
Detailsbinding site for residue SO4 A 203
ChainResidue
ALEU64
AHIS65
ALYS66
site_idAC4
Number of Residues14
Detailsbinding site for residue 6MA A 204
ChainResidue
ATHR8
ALEU9
ALYS23
AASN33
AGLY36
AGLY37
APHE72
APHE74
AMET81
ATRP117
AASP119
AASP120
AHOH311
AHOH314
site_idAC5
Number of Residues4
Detailsbinding site for residue SO4 B 201
ChainResidue
BHIS65
BTHR88
BASP89
BSER90
site_idAC6
Number of Residues12
Detailsbinding site for residue 6MA B 202
ChainResidue
BTHR8
BLEU9
BLYS23
BPHE27
BASN33
BGLY36
BGLY37
BPHE72
BTRP117
BASP119
BASP120
BHOH305
site_idAC7
Number of Residues2
Detailsbinding site for residue GOL B 203
ChainResidue
BTYR148
CARG151
site_idAC8
Number of Residues5
Detailsbinding site for residue SO4 C 201
ChainResidue
CLEU64
CHIS65
CLYS66
CGLY76
CPRO78
site_idAC9
Number of Residues7
Detailsbinding site for residue SO4 C 202
ChainResidue
CALA63
CHIS65
CGLU77
CTHR88
CASP89
CSER90
CHOH304
site_idAD1
Number of Residues19
Detailsbinding site for residue 6MA C 203
ChainResidue
CTYR7
CTHR8
CLYS23
CPHE27
CASN33
CGLY36
CGLY37
CLYS38
CPHE72
CPHE74
CMET81
CGLU100
CTRP117
CASP119
CASP120
CPHE139
CHOH302
CHOH309
CHOH316
site_idAD2
Number of Residues13
Detailsbinding site for residue 6MA D 201
ChainResidue
DTYR7
DTHR8
DLEU9
DPHE27
DASN33
DGLY36
DGLY37
DPHE72
DPHE74
DMET81
DTRP117
DASP119
DASP120
Functional Information from PROSITE/UniProt
site_idPS00893
Number of Residues22
DetailsNUDIX_BOX Nudix box signature. GkvqegEtiedGArRELqEEsG
ChainResidueDetails
AGLY37-GLY58
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues516
DetailsDomain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues84
DetailsMotif: {"description":"Nudix box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30304478","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5OTM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"26999531","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FSK","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"26999531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28035004","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FSI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5GHI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5GHM","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q7ZWC3","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

247947

PDB entries from 2026-01-21

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