5MZE

Crystal structure of mouse MTH1 with 8-oxo-dGTP

Summary for 5MZE

Entry DOI	10.2210/pdb5mze/pdb
Descriptor	7,8-dihydro-8-oxoguanine triphosphatase, COPPER (II) ION, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
Functional Keywords	substrate, complex, hydrolase
Biological source	Mus musculus (House Mouse)
Total number of polymer chains	4
Total formula weight	83057.89
Authors	Narwal, M.,Jemth, A.-S.,Helleday, T.,Stenmark, P. (deposition date: 2017-01-31, release date: 2018-01-10, Last modification date: 2024-01-17)
Primary citation	Narwal, M.,Jemth, A.S.,Gustafsson, R.,Almlof, I.,Warpman Berglund, U.,Helleday, T.,Stenmark, P. Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity. Biochemistry, 57:593-603, 2018 Cited by PubMed: 29281266 DOI: 10.1021/acs.biochem.7b01163 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation