5MZE

Crystal structure of mouse MTH1 with 8-oxo-dGTP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001669	cellular_component	acrosomal vesicle
A	0003723	molecular_function	RNA binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006152	biological_process	purine nucleoside catabolic process
A	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
A	0008828	molecular_function	dATP diphosphatase activity
A	0016787	molecular_function	hydrolase activity
A	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
A	0030515	molecular_function	snoRNA binding
A	0031410	cellular_component	cytoplasmic vesicle
A	0031965	cellular_component	nuclear membrane
A	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
A	0042262	biological_process	DNA protection
A	0046872	molecular_function	metal ion binding
A	0047693	molecular_function	ATP diphosphatase activity
A	0106377	molecular_function	2-hydroxy-ATP hydrolase activity
A	0106378	molecular_function	2-hydroxy-dATP hydrolase activity
A	0106431	molecular_function	N6-methyl-(d)ATP hydrolase activity
A	0106433	molecular_function	O6-methyl-dGTP hydrolase activity
A	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
B	0001669	cellular_component	acrosomal vesicle
B	0003723	molecular_function	RNA binding
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0006152	biological_process	purine nucleoside catabolic process
B	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
B	0008828	molecular_function	dATP diphosphatase activity
B	0016787	molecular_function	hydrolase activity
B	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
B	0030515	molecular_function	snoRNA binding
B	0031410	cellular_component	cytoplasmic vesicle
B	0031965	cellular_component	nuclear membrane
B	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
B	0042262	biological_process	DNA protection
B	0046872	molecular_function	metal ion binding
B	0047693	molecular_function	ATP diphosphatase activity
B	0106377	molecular_function	2-hydroxy-ATP hydrolase activity
B	0106378	molecular_function	2-hydroxy-dATP hydrolase activity
B	0106431	molecular_function	N6-methyl-(d)ATP hydrolase activity
B	0106433	molecular_function	O6-methyl-dGTP hydrolase activity
B	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
C	0001669	cellular_component	acrosomal vesicle
C	0003723	molecular_function	RNA binding
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005829	cellular_component	cytosol
C	0006152	biological_process	purine nucleoside catabolic process
C	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
C	0008828	molecular_function	dATP diphosphatase activity
C	0016787	molecular_function	hydrolase activity
C	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
C	0030515	molecular_function	snoRNA binding
C	0031410	cellular_component	cytoplasmic vesicle
C	0031965	cellular_component	nuclear membrane
C	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
C	0042262	biological_process	DNA protection
C	0046872	molecular_function	metal ion binding
C	0047693	molecular_function	ATP diphosphatase activity
C	0106377	molecular_function	2-hydroxy-ATP hydrolase activity
C	0106378	molecular_function	2-hydroxy-dATP hydrolase activity
C	0106431	molecular_function	N6-methyl-(d)ATP hydrolase activity
C	0106433	molecular_function	O6-methyl-dGTP hydrolase activity
C	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
D	0001669	cellular_component	acrosomal vesicle
D	0003723	molecular_function	RNA binding
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005829	cellular_component	cytosol
D	0006152	biological_process	purine nucleoside catabolic process
D	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
D	0008828	molecular_function	dATP diphosphatase activity
D	0016787	molecular_function	hydrolase activity
D	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
D	0030515	molecular_function	snoRNA binding
D	0031410	cellular_component	cytoplasmic vesicle
D	0031965	cellular_component	nuclear membrane
D	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
D	0042262	biological_process	DNA protection
D	0046872	molecular_function	metal ion binding
D	0047693	molecular_function	ATP diphosphatase activity
D	0106377	molecular_function	2-hydroxy-ATP hydrolase activity
D	0106378	molecular_function	2-hydroxy-dATP hydrolase activity
D	0106431	molecular_function	N6-methyl-(d)ATP hydrolase activity
D	0106433	molecular_function	O6-methyl-dGTP hydrolase activity
D	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue CU A 201

Chain	Residue
A	HIS65
A	ASP89

---

site_id	AC2
Number of Residues	2
Details	binding site for residue CU A 202

Chain	Residue
A	HIS90
A	HIS92

---

site_id	AC3
Number of Residues	8
Details	binding site for residue PEG A 203

Chain	Residue
C	GLN104
C	PHE106
C	HOH315
A	ARG102
A	GLN104
A	HOH341
C	TRP32
C	ARG102

---

site_id	AC4
Number of Residues	23
Details	binding site for residue 8DG A 204

Chain	Residue
A	TYR7
A	THR8
A	LEU9
A	LYS23
A	PHE27
A	ASN33
A	GLY36
A	GLY37
A	LYS38
A	GLU52
A	GLU56
A	PHE72
A	MET81
A	GLU100
A	TRP117
A	ASP119
A	ASP120
A	TRP123
A	HOH312
A	HOH331
A	HOH339
A	HOH347
A	HOH355

---

site_id	AC5
Number of Residues	2
Details	binding site for residue CU B 201

Chain	Residue
B	HIS65
B	ASP89

---

site_id	AC6
Number of Residues	6
Details	binding site for residue GOL B 202

Chain	Residue
B	ARG17
B	TRP105
B	GLN107
D	ARG17
D	TRP105
D	GLN107

---

site_id	AC7
Number of Residues	19
Details	binding site for residue 8DG B 203

Chain	Residue
B	TYR7
B	THR8
B	LEU9
B	LYS23
B	PHE27
B	ASN33
B	GLY36
B	GLY37
B	LYS38
B	GLU52
B	PHE72
B	MET81
B	GLU100
B	TRP117
B	ASP119
B	ASP120
B	TRP123
B	HOH327
B	HOH345

---

site_id	AC8
Number of Residues	1
Details	binding site for residue CU C 201

Chain	Residue
C	ASP89

---

site_id	AC9
Number of Residues	19
Details	binding site for residue 8DG C 202

Chain	Residue
C	TYR7
C	THR8
C	LEU9
C	LYS23
C	PHE27
C	ASN33
C	GLY36
C	GLY37
C	LYS38
C	GLU52
C	PHE72
C	MET81
C	GLU100
C	TRP117
C	ASP119
C	ASP120
C	TRP123
C	HOH313
C	HOH317

---

site_id	AD1
Number of Residues	8
Details	binding site for residue PEG D 201

Chain	Residue
B	ARG102
B	GLN104
B	HOH302
D	TRP32
D	ARG102
D	GLN104
D	PHE106
D	HOH322

---

site_id	AD2
Number of Residues	20
Details	binding site for residue 8DG D 202

Chain	Residue
D	GLU52
D	GLU56
D	PHE72
D	MET81
D	GLU100
D	TRP117
D	ASP119
D	ASP120
D	TRP123
D	HOH304
D	HOH361
D	TYR7
D	THR8
D	LEU9
D	LYS23
D	PHE27
D	ASN33
D	GLY36
D	GLY37
D	LYS38

---

Functional Information from PROSITE/UniProt

site_id	PS00893
Number of Residues	22
Details	NUDIX_BOX Nudix box signature. GkvqegEtiedGAkRELlEEsG

Chain	Residue	Details
A	GLY37-GLY58

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	Motif: {"description":"Nudix box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29281266","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5MZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q7ZWC3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	258
Details	Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---