5MZG

Crystal structure of mouse MTH1 in complex with TH588

Summary for 5MZG

• Entry DOI: 10.2210/pdb5mzg/pdb
• Related: 5MZG
• Descriptor: 7,8-dihydro-8-oxoguanine triphosphatase, N~4~-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine, SULFATE ION, ... (5 entities in total)
• Functional Keywords: inhibitor, complex, hydrolase
• Biological source: Mus musculus (House Mouse)
• Cellular location: Cytoplasm: P53368
• Total number of polymer chains: 2
• Total formula weight: 41314.18

Authors

Narwal, M.,Jemth, A.-S.,Helleday, T.,Stenmark, P. (deposition date: 2017-01-31, release date: 2018-01-10, Last modification date: 2024-01-17)

• Primary citation: Narwal, M.,Jemth, A.S.,Gustafsson, R.,Almlof, I.,Warpman Berglund, U.,Helleday, T.,Stenmark, P.; Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity.; Biochemistry, 57:593-603, 2018; PubMed: 29281266; DOI: 10.1021/acs.biochem.7b01163

Experimental method

X-RAY DIFFRACTION (1.85 Å)