5MZG

Crystal structure of mouse MTH1 in complex with TH588

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001669	cellular_component	acrosomal vesicle
A	0003723	molecular_function	RNA binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006152	biological_process	purine nucleoside catabolic process
A	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
A	0008828	molecular_function	dATP diphosphatase activity
A	0016787	molecular_function	hydrolase activity
A	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
A	0030515	molecular_function	snoRNA binding
A	0031410	cellular_component	cytoplasmic vesicle
A	0031965	cellular_component	nuclear membrane
A	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
A	0042262	biological_process	DNA protection
A	0046872	molecular_function	metal ion binding
A	0047693	molecular_function	ATP diphosphatase activity
A	0106377	molecular_function	2-hydroxy-ATP hydrolase activity
A	0106378	molecular_function	2-hydroxy-dATP hydrolase activity
A	0106431	molecular_function	N6-methyl-(d)ATP hydrolase activity
A	0106433	molecular_function	O6-methyl-dGTP hydrolase activity
A	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
B	0001669	cellular_component	acrosomal vesicle
B	0003723	molecular_function	RNA binding
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0006152	biological_process	purine nucleoside catabolic process
B	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
B	0008828	molecular_function	dATP diphosphatase activity
B	0016787	molecular_function	hydrolase activity
B	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
B	0030515	molecular_function	snoRNA binding
B	0031410	cellular_component	cytoplasmic vesicle
B	0031965	cellular_component	nuclear membrane
B	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
B	0042262	biological_process	DNA protection
B	0046872	molecular_function	metal ion binding
B	0047693	molecular_function	ATP diphosphatase activity
B	0106377	molecular_function	2-hydroxy-ATP hydrolase activity
B	0106378	molecular_function	2-hydroxy-dATP hydrolase activity
B	0106431	molecular_function	N6-methyl-(d)ATP hydrolase activity
B	0106433	molecular_function	O6-methyl-dGTP hydrolase activity
B	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 2GE A 201

Chain	Residue
A	THR8
A	PHE139
A	SO4202
A	PHE27
A	ASN33
A	PHE72
A	PHE74
A	TRP117
A	ASP119
A	ASP120
A	TRP123

---

site_id	AC2
Number of Residues	9
Details	binding site for residue SO4 A 202

Chain	Residue
A	LEU9
A	LYS23
A	ASN33
A	GLY34
A	GLY36
A	GLU56
A	MET101
A	2GE201
A	HOH365

---

site_id	AC3
Number of Residues	4
Details	binding site for residue SCN A 203

Chain	Residue
A	LEU108
A	ASP109
A	GLN110
A	ILE111

---

site_id	AC4
Number of Residues	6
Details	binding site for residue SCN A 204

Chain	Residue
A	HIS69
A	SER71
A	GLY135
B	GLY135
B	HIS136
B	SCN205

---

site_id	AC5
Number of Residues	13
Details	binding site for residue 2GE B 201

Chain	Residue
B	TYR7
B	THR8
B	LEU9
B	PHE27
B	ASN33
B	PHE72
B	PHE74
B	TRP117
B	ASP119
B	ASP120
B	TRP123
B	PHE139
B	SO4202

---

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 B 202

Chain	Residue
B	LYS23
B	ASN33
B	GLY34
B	GLY36
B	GLU56
B	2GE201
B	HOH314

---

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 B 203

Chain	Residue
B	TYR7
B	PHE27
B	GLN140

---

site_id	AC8
Number of Residues	4
Details	binding site for residue SCN B 204

Chain	Residue
B	PRO103
B	GLN104
B	TRP105
B	HOH320

---

site_id	AC9
Number of Residues	7
Details	binding site for residue SCN B 205

Chain	Residue
A	GLY135
A	HIS136
A	SER149
A	SCN204
B	HIS69
B	SER71
B	GLY135

---

Functional Information from PROSITE/UniProt

site_id	PS00893
Number of Residues	22
Details	NUDIX_BOX Nudix box signature. GkvqegEtiedGAkRELlEEsG

Chain	Residue	Details
A	GLY37-GLY58

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	258
Details	Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	42
Details	Motif: {"description":"Nudix box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29281266","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5MZE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q7ZWC3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---