7AOM

Structure of NUDT15 in complex with Ganciclovir triphosphate

Summary for 7AOM

Entry DOI	10.2210/pdb7aom/pdb
Descriptor	Nucleotide triphosphate diphosphatase NUDT15, Ganciclovir triphosphate, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	nudix hydrolase, antiviral, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	38308.95
Authors	Rehling, D.,Zhang, S.M.,Helleday, T.,Stenmark, P. (deposition date: 2020-10-14, release date: 2021-06-02, Last modification date: 2024-01-31)
Primary citation	Zhang, S.M.,Rehling, D.,Jemth, A.S.,Throup, A.,Landazuri, N.,Almlof, I.,Gottmann, M.,Valerie, N.C.K.,Borhade, S.R.,Wakchaure, P.,Page, B.D.G.,Desroses, M.,Homan, E.J.,Scobie, M.,Rudd, S.G.,Berglund, U.W.,Soderberg-Naucler, C.,Stenmark, P.,Helleday, T. NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir. Cell Chem Biol, 28:1693-1702.e6, 2021 Cited by PubMed: 34192523 DOI: 10.1016/j.chembiol.2021.06.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation