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5HPK
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BU of 5hpk by Molmil
System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: NEDD4L and UbV NL.1
Descriptor: E3 ubiquitin-protein ligase NEDD4-like, Ubiquitin variant NL.1
Authors:Wu, K.-P, Mukherjee, M, Mercredi, P.Y, Schulman, B.A.
Deposit date:2016-01-20
Release date:2016-03-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.431 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5HPT
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BU of 5hpt by Molmil
System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: WWP1, Ubv P2.3 and UBCH7
Descriptor: NEDD4-like E3 ubiquitin-protein ligase WWP1, Ubiquitin variant P2.3, Ubiquitin-conjugating enzyme E2 L3
Authors:Wu, K.-P, Schulman, B.A.
Deposit date:2016-01-20
Release date:2016-03-16
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5HPL
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BU of 5hpl by Molmil
System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: Rsp5 and UbV R5.4
Descriptor: Rsp5, Ubiquitin variant R5.4
Authors:Wu, K.-P, Kamadurai, H.B, Schulman, B.A.
Deposit date:2016-01-20
Release date:2016-03-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
5HPS
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BU of 5hps by Molmil
System-wide modulation of HECT E3 ligases with selective ubiquitin variant probes: WWP1 and UbV P1.1
Descriptor: Ubiquitin variant P1.1, WWP1 HECT
Authors:Wu, K.-P, Mercredi, P.Y, Schulman, B.A.
Deposit date:2016-01-20
Release date:2016-03-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.
Mol.Cell, 62, 2016
6NXL
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BU of 6nxl by Molmil
Ubiquitin binding variants
Descriptor: Polyubiquitin-B
Authors:Miller, D.J, Watson, E.R.
Deposit date:2019-02-08
Release date:2020-01-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.
Proc.Natl.Acad.Sci.USA, 116, 2019
6NJG
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BU of 6njg by Molmil
Ubiquitin Variant in Complex with Ubiquitin Interacting Motif
Descriptor: Polyubiquitin-B, Vacuolar protein sorting-associated protein 27
Authors:Manczyk, N, Sicheri, F.
Deposit date:2019-01-03
Release date:2019-03-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Dimerization of a ubiquitin variant leads to high affinity interactions with a ubiquitin interacting motif.
Protein Sci., 28, 2019
5IBK
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BU of 5ibk by Molmil
Skp1-F-box in complex with a ubiquitin variant
Descriptor: F-box/WD repeat-containing protein 7, Polyubiquitin-B, S-phase kinase-associated protein 1,S-phase kinase-associated protein 1
Authors:Orlicky, S, Sicheri, F.
Deposit date:2016-02-22
Release date:2016-03-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface.
Proc.Natl.Acad.Sci.USA, 113, 2016
6O3A
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BU of 6o3a by Molmil
Crystal structure of Frizzled 7 CRD in complex with F7.B Fab
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, ...
Authors:Raman, S, Beilschmidt, M, Fransson, J, Julien, J.P.
Deposit date:2019-02-26
Release date:2019-04-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6O3B
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BU of 6o3b by Molmil
Crystal structure of Frizzled 7 CRD in complex with F6 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab F6, Heavy chain, ...
Authors:Raman, S, Beilschmidt, M, Fransson, J, Julien, J.P.
Deposit date:2019-02-26
Release date:2019-04-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6O39
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BU of 6o39 by Molmil
Crystal structure of Frizzled 5 CRD in complex with F2.I Fab
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ...
Authors:Raman, S, Beilschmidt, M, Fransson, J, Julien, J.P.
Deposit date:2019-02-26
Release date:2019-04-03
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6NXK
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BU of 6nxk by Molmil
Ubiquitin binding variants
Descriptor: Anaphase-promoting complex subunit 2, Polyubiquitin-C
Authors:Miller, D.J, Watson, E.R.
Deposit date:2019-02-08
Release date:2020-01-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.
Proc.Natl.Acad.Sci.USA, 116, 2019
5V6A
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BU of 5v6a by Molmil
Crystal structure of the Middle East respiratory syndrome coronavirus papain-like protease bound to ubiquitin variant ME.2
Descriptor: CHLORIDE ION, CITRATE ANION, ME.2, ...
Authors:Bailey-Elkin, B.A, Mark, B.L.
Deposit date:2017-03-16
Release date:2017-05-10
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants.
PLoS Pathog., 13, 2017
5V5H
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BU of 5v5h by Molmil
OTU protease of Crimean Congo Hemorrhagic Fever Virus bound to ubiquitin variant CC.2
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, RNA-directed RNA polymerase L, SODIUM ION, ...
Authors:Khare, B, Mark, B.L.
Deposit date:2017-03-14
Release date:2017-05-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants.
PLoS Pathog., 13, 2017
5V69
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BU of 5v69 by Molmil
Crystal structure of the Middle East respiratory syndrome coronavirus papain-like protease bound to ubiquitin variant ME.4
Descriptor: CHLORIDE ION, ME.4, MERS-CoV PLpro, ...
Authors:Bailey-Elkin, B.A, Mark, B.L.
Deposit date:2017-03-16
Release date:2017-05-10
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants.
PLoS Pathog., 13, 2017
5V5G
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BU of 5v5g by Molmil
OTU protease of Crimean Congo Hemorrhagic Fever Virus bound to ubiquitin variant CC.4
Descriptor: 1,2-ETHANEDIOL, RNA-directed RNA polymerase L, SODIUM ION, ...
Authors:Khare, B, Mark, B.L.
Deposit date:2017-03-14
Release date:2017-05-10
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants.
PLoS Pathog., 13, 2017
5V5I
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BU of 5v5i by Molmil
OTU protease of Crimean Congo Hemorrhagic Fever Virus bound to ubiquitin variant CC.1
Descriptor: RNA-directed RNA polymerase L, Ubiquitin variant CC.1
Authors:Khare, B, Mark, B.L.
Deposit date:2017-03-14
Release date:2017-05-10
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:OTU protease of Crimean Congo Hemorrhagic Fever Virus bound to ubiquitin variant CC.1
To be published
1PMX
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BU of 1pmx by Molmil
INSULIN-LIKE GROWTH FACTOR-I BOUND TO A PHAGE-DERIVED PEPTIDE
Descriptor: IGF-1 ANTAGONIST F1-1, Insulin-like growth factor IB
Authors:Skelton, N.J.
Deposit date:2003-06-11
Release date:2003-10-21
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Complex with a Phage Display-Derived Peptide Provides Insight into the Function of Insulin-like Growth Factor I
Biochemistry, 42, 2003
6C16
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BU of 6c16 by Molmil
Ubiquitin variant (UbV.Fbl10.1) bound to a human Skp1-Fbl11 fragment complex.
Descriptor: Lysine-specific demethylase 2A, Polyubiquitin-B, S-phase kinase-associated protein 1
Authors:Manczyk, N, Sicheri, F.
Deposit date:2018-01-04
Release date:2018-07-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.27 Å)
Cite:A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases.
Structure, 26, 2018
3CC0
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BU of 3cc0 by Molmil
The Dvl2 PDZ Domain in Complex with the N3 Inhibitory Peptide
Descriptor: Dishevelled-2
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2008-02-23
Release date:2009-03-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Inhibition of Wnt signaling by Dishevelled PDZ peptides
Nat.Chem.Biol., 5, 2009
3CBX
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BU of 3cbx by Molmil
The Dvl2 PDZ Domain in Complex with the C1 Inhibitory Peptide
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Dishevelled-2
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2008-02-23
Release date:2009-03-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Inhibition of Wnt signaling by Dishevelled PDZ peptides
Nat.Chem.Biol., 5, 2009
3CBY
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BU of 3cby by Molmil
The Dvl2 PDZ Domain in Complex with the N1 Inhibitory Peptide
Descriptor: 1,2-ETHANEDIOL, Dishevelled-2
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2008-02-23
Release date:2009-03-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Inhibition of Wnt signaling by Dishevelled PDZ peptides
Nat.Chem.Biol., 5, 2009
3CBZ
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BU of 3cbz by Molmil
The Dvl2 PDZ Domain in Complex with the N2 Inhibitory Peptide
Descriptor: 1,2-ETHANEDIOL, Dishevelled-2, PHOSPHATE ION
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2008-02-23
Release date:2009-03-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Inhibition of Wnt signaling by Dishevelled PDZ peptides
Nat.Chem.Biol., 5, 2009
6DGF
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BU of 6dgf by Molmil
Ubiquitin Variant bound to USP2
Descriptor: Polyubiquitin-B, SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 2, ...
Authors:Manczyk, N, Sicheri, F.
Deposit date:2018-05-17
Release date:2019-02-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases.
J. Mol. Biol., 431, 2019
3DVG
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BU of 3dvg by Molmil
Crystal structure of K63-specific fab Apu.3A8 bound to K63-linked di-ubiquitin
Descriptor: Human IgG1 fab fragment heavy chain, Human IgG1 fab fragment light chain, Ubiquitin, ...
Authors:Hymowitz, S.G.
Deposit date:2008-07-18
Release date:2008-09-30
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies.
Cell(Cambridge,Mass.), 134, 2008
3CSB
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BU of 3csb by Molmil
Crystal Structure of Monobody YSX1/Maltose Binding Protein Fusion Complex
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, ...
Authors:Gilbreth, R.N, Koide, S.
Deposit date:2008-04-09
Release date:2008-07-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:A Dominant Conformational Role for Amino Acid Diversity in Minimalist Protein-Protein Interfaces
J.Mol.Biol., 381, 2008

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數據於2024-11-06公開中

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