6O39

Crystal structure of Frizzled 5 CRD in complex with F2.I Fab

Summary for 6O39

Entry DOI	10.2210/pdb6o39/pdb
Descriptor	Antibody F2.I Fab, Light chain, Antibody F2.I Fab, Heavy chain, Frizzled-5, ... (7 entities in total)
Functional Keywords	receptor, wnt, frizzled, crd, antibody, signaling protein
Biological source	Homo sapiens More
Total number of polymer chains	3
Total formula weight	61757.36
Authors	Raman, S.,Beilschmidt, M.,Fransson, J.,Julien, J.P. (deposition date: 2019-02-26, release date: 2019-04-03, Last modification date: 2023-10-11)
Primary citation	Raman, S.,Beilschmidt, M.,To, M.,Lin, K.,Lui, F.,Jmeian, Y.,Ng, M.,Fernandez, M.,Fu, Y.,Mascall, K.,Duque, A.,Wang, X.,Pan, G.,Angers, S.,Moffat, J.,Sidhu, S.S.,Magram, J.,Sinclair, A.M.,Fransson, J.,Julien, J.P. Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. Proc. Natl. Acad. Sci. U.S.A., 116:6812-6817, 2019 Cited by PubMed: 30894493 DOI: 10.1073/pnas.1817246116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation