5XNH
 
 | | Crystal structure of the branched-chain polyamine synthase (BpsA) in complex with spermidine | | Descriptor: | FE (III) ION, N(4)-bis(aminopropyl)spermidine synthase, SPERMIDINE | | Authors: | Mizohata, E, Tse, K.M, Fujita, J, Inoue, T. | | Deposit date: | 2017-05-22 | | Release date: | 2017-10-04 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile-specific branched-chain polyamine.
FEBS J., 284, 2017
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1C52
 | | THERMUS THERMOPHILUS CYTOCHROME-C552: A NEW HIGHLY THERMOSTABLE CYTOCHROME-C STRUCTURE OBTAINED BY MAD PHASING | | Descriptor: | CYTOCHROME-C552, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Than, M.E, Hof, P, Huber, R, Bourenkov, G.P, Bartunik, H.D, Buse, G, Soulimane, T. | | Deposit date: | 1997-06-23 | | Release date: | 1998-06-24 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.28 Å) | | Cite: | Thermus thermophilus cytochrome-c552: A new highly thermostable cytochrome-c structure obtained by MAD phasing.
J.Mol.Biol., 271, 1997
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6KX8
 | | Crystal structure of mouse Cryptochrome 2 in complex with TH301 compound | | Descriptor: | 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide, Cryptochrome-2 | | Authors: | Miller, S.A, Aikawa, Y, Hirota, T. | | Deposit date: | 2019-09-10 | | Release date: | 2020-04-01 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Isoform-selective regulation of mammalian cryptochromes.
Nat.Chem.Biol., 16, 2020
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6KX7
 | | Crystal structure of mouse Cryptochrome 1 in complex with TH301 compound | | Descriptor: | 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide, Cryptochrome-1 | | Authors: | Miller, S.A, Aikawa, Y, Hirota, T. | | Deposit date: | 2019-09-10 | | Release date: | 2020-04-01 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Isoform-selective regulation of mammalian cryptochromes.
Nat.Chem.Biol., 16, 2020
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6KX5
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6KX4
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6KX6
 | | Crystal structure of mouse Cryptochrome 1 in complex with KL101 compound | | Descriptor: | Cryptochrome-1, ~{N}-[2-(2,4-dimethylphenyl)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-3,4-dimethyl-benzamide | | Authors: | Miller, S.A, Aikawa, Y, Hirota, T. | | Deposit date: | 2019-09-10 | | Release date: | 2020-04-01 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Isoform-selective regulation of mammalian cryptochromes.
Nat.Chem.Biol., 16, 2020
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5XNC
 | | Crystal structure of the branched-chain polyamine synthase (BpsA) in complex with N4-aminopropylspermidine and 5-methylthioadenosine | | Descriptor: | 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Mizohata, E, Tse, K.M, Fujita, J, Inoue, T. | | Deposit date: | 2017-05-22 | | Release date: | 2018-08-15 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile-specific branched-chain polyamine.
FEBS J., 284, 2017
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6J27
 | | Crystal structure of the branched-chain polyamine synthase from Thermus thermophilus (Tth-BpsA) in complex with N4-aminopropylspermidine and 5'-methylthioadenosine | | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, DI(HYDROXYETHYL)ETHER, FE (III) ION, ... | | Authors: | Mizohata, E, Toyoda, M, Fujita, J, Inoue, T. | | Deposit date: | 2018-12-31 | | Release date: | 2019-06-26 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.66 Å) | | Cite: | The C-terminal flexible region of branched-chain polyamine synthase facilitates substrate specificity and catalysis.
Febs J., 286, 2019
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6J28
 | | Crystal structure of the branched-chain polyamine synthase C9 mutein from Thermus thermophilus (Tth-BpsA C9) in complex with N4-aminopropylspermidine and 5'-methylthioadenosine | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5'-DEOXY-5'-METHYLTHIOADENOSINE, FE (III) ION, ... | | Authors: | Mizohata, E, Toyoda, M, Fujita, J, Inoue, T. | | Deposit date: | 2018-12-31 | | Release date: | 2019-06-26 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The C-terminal flexible region of branched-chain polyamine synthase facilitates substrate specificity and catalysis.
Febs J., 286, 2019
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6J26
 | | Crystal structure of the branched-chain polyamine synthase from Thermococcus kodakarensis (Tk-BpsA) in complex with N4-bis(aminopropyl)spermidine and 5'-methylthioadenosine | | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, FE (III) ION, N(4)-bis(aminopropyl)spermidine synthase, ... | | Authors: | Mizohata, E, Toyoda, M, Fujita, J, Inoue, T. | | Deposit date: | 2018-12-31 | | Release date: | 2019-06-26 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The C-terminal flexible region of branched-chain polyamine synthase facilitates substrate specificity and catalysis.
Febs J., 286, 2019
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7D1C
 | | Crystal structure of mouse Cryptochrome 1 in complex with compound TH303 | | Descriptor: | Cryptochrome-1, N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-4-(phenylcarbonyl)benzamide | | Authors: | Miller, S.A, Hirota, T. | | Deposit date: | 2020-09-14 | | Release date: | 2021-01-27 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock.
J.Am.Chem.Soc., 143, 2021
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7D19
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1GC3
 | | THERMUS THERMOPHILUS ASPARTATE AMINOTRANSFERASE TETRA MUTANT 2 COMPLEXED WITH TRYPTOPHAN | | Descriptor: | ASPARTATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, TRYPTOPHAN | | Authors: | Ura, H, Nakai, T, Hirotsu, K, Kuramitsu, S. | | Deposit date: | 2000-07-18 | | Release date: | 2001-09-05 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Substrate recognition mechanism of thermophilic dual-substrate enzyme.
J.Biochem., 130, 2001
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1GC4
 | | THERMUS THERMOPHILUS ASPARTATE AMINOTRANSFERASE TETRA MUTANT 2 COMPLEXED WITH ASPARTATE | | Descriptor: | ASPARTATE AMINOTRANSFERASE, ASPARTIC ACID, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Ura, H, Nakai, T, Hirotsu, K, Kuramitsu, S. | | Deposit date: | 2000-07-19 | | Release date: | 2001-09-05 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Substrate recognition mechanism of thermophilic dual-substrate enzyme.
J.Biochem., 130, 2001
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1GCK
 | | THERMUS THERMOPHILUS ASPARTATE AMINOTRANSFERASE DOUBLE MUTANT 1 COMPLEXED WITH ASPARTATE | | Descriptor: | ASPARTATE AMINOTRANSFERASE, ASPARTIC ACID, PYRIDOXAL-5'-PHOSPHATE | | Authors: | Ura, H, Nakai, T, Hirotsu, K, Kuramitsu, S. | | Deposit date: | 2000-08-04 | | Release date: | 2001-11-14 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Substrate recognition mechanism of thermophilic dual-substrate enzyme.
J.Biochem., 130, 2001
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7F4B
 | | The crystal structure of the immature apo-enzyme of homoserine dehydrogenase from the hyperthermophilic archaeon Sulfurisphaera tokodaii. | | Descriptor: | MAGNESIUM ION, homoserine dehydrogenase | | Authors: | Kurihara, E, Kubota, T, Watanabe, K, Ogata, K, Kaneko, R, Oshima, T, Yoshimune, K, Goto, M. | | Deposit date: | 2021-06-18 | | Release date: | 2022-06-22 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Conformational changes in the catalytic region are responsible for heat-induced activation of hyperthermophilic homoserine dehydrogenase.
Commun Biol, 5, 2022
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7F4C
 | | The crystal structure of the immature holo-enzyme of homoserine dehydrogenase complexed with NADP and 1,4-butandiol from the hyperthermophilic archaeon Sulfurisphaera tokodaii. | | Descriptor: | 1,4-BUTANEDIOL, Homoserine dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Ogata, K, Kaneko, R, Kubota, T, Watanabe, K, Kurihara, E, Oshima, T, Yoshimune, K, Goto, M. | | Deposit date: | 2021-06-18 | | Release date: | 2022-06-22 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Conformational changes in the catalytic region are responsible for heat-induced activation of hyperthermophilic homoserine dehydrogenase.
Commun Biol, 5, 2022
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5XWU
 | | Crystal structure of PTPdelta Ig1-Ig3 in complex with SALM2 LRR-Ig | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Goto-Ito, S, Yamagata, A, Sato, Y, Fukai, S. | | Deposit date: | 2017-06-30 | | Release date: | 2018-06-06 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3.162 Å) | | Cite: | Structural basis of trans-synaptic interactions between PTP delta and SALMs for inducing synapse formation.
Nat Commun, 9, 2018
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4TZ4
 | | Crystal Structure of Human Cereblon in Complex with DDB1 and Lenalidomide | | Descriptor: | DNA damage-binding protein 1, Protein cereblon, S-Lenalidomide, ... | | Authors: | Chamberlain, P.P, Pagarigan, B, Delker, S, Leon, B, Riley, M. | | Deposit date: | 2014-07-09 | | Release date: | 2014-08-06 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (3.01 Å) | | Cite: | Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
To Be Published
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4TZC
 | | Crystal Structure of Murine Cereblon in Complex with Thalidomide | | Descriptor: | Protein cereblon, S-Thalidomide, SULFATE ION, ... | | Authors: | Chamberlain, P.P, Pagarigan, B, Delker, S, Leon, B. | | Deposit date: | 2014-07-10 | | Release date: | 2014-08-06 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
to be published
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4TZU
 | | Crystal Structure of Murine Cereblon in Complex with Pomalidomide | | Descriptor: | Protein cereblon, S-Pomalidomide, SULFATE ION, ... | | Authors: | Chamberlain, P.P, Pagarigan, B, Delker, S, Leon, B. | | Deposit date: | 2014-07-10 | | Release date: | 2014-08-06 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
to be published
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6LEP
 | | Crystal structure of thiosulfate transporter YeeE inactive mutant - C91A | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Sulf_transp domain-containing protein, THIOSULFATE | | Authors: | Tanaka, Y, Tsukazaki, T, Yoshikaie, K, Sugano, Y, Takeuchi, A, Uchino, S. | | Deposit date: | 2019-11-26 | | Release date: | 2020-09-02 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of a YeeE/YedE family protein engaged in thiosulfate uptake.
Sci Adv, 6, 2020
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6LEO
 | | Crystal structure of thiosulfate transporter YeeE from Spirochaeta thermophila | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Sulf_transp domain-containing protein, THIOSULFATE | | Authors: | Tanaka, Y, Tsukazaki, T, Yoshikaie, K, Takeuchi, A, Uchino, S, Sugano, Y. | | Deposit date: | 2019-11-26 | | Release date: | 2020-09-02 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | Crystal structure of a YeeE/YedE family protein engaged in thiosulfate uptake.
Sci Adv, 6, 2020
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5Z8X
 | | Crystal structure of human LRRTM2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Leucine-rich repeat transmembrane neuronal protein 2 | | Authors: | Yamagata, A, Fukai, S. | | Deposit date: | 2018-02-01 | | Release date: | 2018-10-10 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction.
Nat Commun, 9, 2018
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