7F4C

The crystal structure of the immature holo-enzyme of homoserine dehydrogenase complexed with NADP and 1,4-butandiol from the hyperthermophilic archaeon Sulfurisphaera tokodaii.

Summary for 7F4C

• Entry DOI: 10.2210/pdb7f4c/pdb
• Related: 7F4B
• Descriptor: Homoserine dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1,4-BUTANEDIOL, ... (4 entities in total)
• Functional Keywords: heat-induced activation, oxidoreductase
• Biological source: Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii)
• Total number of polymer chains: 2
• Total formula weight: 68490.04

Authors

Ogata, K.,Kaneko, R.,Kubota, T.,Watanabe, K.,Kurihara, E.,Oshima, T.,Yoshimune, K.,Goto, M. (deposition date: 2021-06-18, release date: 2022-06-22, Last modification date: 2023-11-29)

• Primary citation: Kubota, T.,Kurihara, E.,Watanabe, K.,Ogata, K.,Kaneko, R.,Goto, M.,Ohshima, T.,Yoshimune, K.; Conformational changes in the catalytic region are responsible for heat-induced activation of hyperthermophilic homoserine dehydrogenase.; Commun Biol, 5:704-704, 2022; PubMed: 35835834; DOI: 10.1038/s42003-022-03656-7

Experimental method

X-RAY DIFFRACTION (1.9 Å)