6KX8

Crystal structure of mouse Cryptochrome 2 in complex with TH301 compound

Summary for 6KX8

Entry DOI	10.2210/pdb6kx8/pdb
Descriptor	Cryptochrome-2, 1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]cyclopentane-1-carboxamide (3 entities in total)
Functional Keywords	circadian clock protein
Biological source	Mus musculus (Mouse)
Total number of polymer chains	2
Total formula weight	118666.36
Authors	Miller, S.A.,Aikawa, Y.,Hirota, T. (deposition date: 2019-09-10, release date: 2020-04-01, Last modification date: 2023-11-22)
Primary citation	Miller, S.,Son, Y.L.,Aikawa, Y.,Makino, E.,Nagai, Y.,Srivastava, A.,Oshima, T.,Sugiyama, A.,Hara, A.,Abe, K.,Hirata, K.,Oishi, S.,Hagihara, S.,Sato, A.,Tama, F.,Itami, K.,Kay, S.A.,Hatori, M.,Hirota, T. Isoform-selective regulation of mammalian cryptochromes. Nat.Chem.Biol., 16:676-685, 2020 Cited by PubMed: 32231341 DOI: 10.1038/s41589-020-0505-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation