4TZC

Crystal Structure of Murine Cereblon in Complex with Thalidomide

Summary for 4TZC

DescriptorProtein cereblon, ZINC ION, S-Thalidomide, ... (5 entities in total)
Functional Keywordsubiquitin ligase, dcaf, ligase
Biological sourceMus musculus (Mouse)
Cellular locationCytoplasm  Q8C7D2
Total number of polymer chains4
Total molecular weight50294.7
Authors
Chamberlain, P.P.,Pagarigan, B.,Delker, S.,Leon, B. (deposition date: 2014-07-10, release date: 2014-08-06, Last modification date: 2017-09-27)
Primary citation
Chamberlain, P.P.,Lopez-Girona, A.,Miller, K.,Carmel, G.,Pagarigan, B.,Leon, B.,Rychak, E.,Corral, L.,Ren, Y.,Wang, M.,Riley, M.,Delker, S.,Ito, T.,Hideki, A.,Mori, T.,Hirano, Y.,Handa, H.,Hakoshima, T.,Daniel, T.O.,Cathers, B.E.
Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
to be published,
Experimental method
X-RAY DIFFRACTION (1.88 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2209 0.8% 2.0% 4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
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PDB entries from 2020-09-23