Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4TZC

Crystal Structure of Murine Cereblon in Complex with Thalidomide

Summary for 4TZC
Entry DOI10.2210/pdb4tzc/pdb
DescriptorProtein cereblon, ZINC ION, S-Thalidomide, ... (5 entities in total)
Functional Keywordsubiquitin ligase, dcaf, ligase
Biological sourceMus musculus (Mouse)
Cellular locationCytoplasm : Q8C7D2
Total number of polymer chains4
Total formula weight50294.70
Authors
Chamberlain, P.P.,Pagarigan, B.,Delker, S.,Leon, B. (deposition date: 2014-07-10, release date: 2014-08-06, Last modification date: 2023-12-27)
Primary citationChamberlain, P.P.,Lopez-Girona, A.,Miller, K.,Carmel, G.,Pagarigan, B.,Leon, B.,Rychak, E.,Corral, L.,Ren, Y.,Wang, M.,Riley, M.,Delker, S.,Ito, T.,Hideki, A.,Mori, T.,Hirano, Y.,Handa, H.,Hakoshima, T.,Daniel, T.O.,Cathers, B.E.
Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
to be published,
Experimental method
X-RAY DIFFRACTION (1.88 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon