Crystal Structure of Murine Cereblon in Complex with Thalidomide

Summary for 4TZC

DescriptorProtein cereblon, ZINC ION, S-Thalidomide, ... (5 entities in total)
Functional Keywordsubiquitin ligase, dcaf, ligase
Biological sourceMus musculus (Mouse)
Cellular locationCytoplasm  Q8C7D2
Total number of polymer chains4
Total molecular weight50294.7
Chamberlain, P.P.,Pagarigan, B.,Delker, S.,Leon, B. (deposition date: 2014-07-10, release date: 2014-08-06, Last modification date: 2017-09-27)
Primary citation
Chamberlain, P.P.,Lopez-Girona, A.,Miller, K.,Carmel, G.,Pagarigan, B.,Leon, B.,Rychak, E.,Corral, L.,Ren, Y.,Wang, M.,Riley, M.,Delker, S.,Ito, T.,Hideki, A.,Mori, T.,Hirano, Y.,Handa, H.,Hakoshima, T.,Daniel, T.O.,Cathers, B.E.
Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
to be published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2209 0.8% 2.0% 4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-09-23