4TZC
Crystal Structure of Murine Cereblon in Complex with Thalidomide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (C, A, B, D) | Protein cereblon | polymer | 108 | 12057.9 | 4 | UniProt (Q8C7D2) Pfam (PF03226) | Mus musculus (Mouse) | Protein PiL |
| 2 | E, G, K, P (C, A, B, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, J, O, T (C, A, B, D) | S-Thalidomide | non-polymer | 258.2 | 4 | Chemie (EF2) | |||
| 4 | H, I, L, M, N... (A, B, D) | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 5 | U, V, W, X (C, A, B, D) | water | water | 18.0 | 365 | Chemie (HOH) |
Sequence modifications
C, A, B, D: 321 - 427 (UniProt: Q8C7D2)
| PDB | External Database | Details |
|---|---|---|
| Ser 320 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 48231.6 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2063.1 | |
| All* | Total formula weight | 50294.7 |
