5HYC
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![BU of 5hyc by Molmil](/molmil-images/mine/5hyc) | Structure based function annotation of a hypothetical protein MGG_01005 related to the development of rice blast fungus | Descriptor: | Cytoplasmic dynein 1 intermediate chain 2, Uncharacterized protein | Authors: | Liu, J, Li, G, Huang, J, Peng, Y.-l. | Deposit date: | 2016-02-01 | Release date: | 2017-02-01 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure based function-annotation of hypothetical protein MGG_01005 from Magnaporthe oryzae reveals it is the dynein light chain orthologue of dynlt1/3. Sci Rep, 8, 2018
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4YLW
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![BU of 4ylw by Molmil](/molmil-images/mine/4ylw) | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with No.33 compound | Descriptor: | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ... | Authors: | Wu, D, Ouyang, P, Lu, W, Huang, J. | Deposit date: | 2015-03-06 | Release date: | 2016-03-09 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with No.33 compound To Be Published
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8FHD
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![BU of 8fhd by Molmil](/molmil-images/mine/8fhd) | Cryo-EM structure of human voltage-gated sodium channel Nav1.6 | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, (5E,17R,20S)-23-amino-20-hydroxy-14,20-dioxo-15,19,21-trioxa-20lambda~5~-phosphatricos-5-en-17-yl hexadecanoate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | Authors: | Fan, X, Huang, J, Yan, N. | Deposit date: | 2022-12-14 | Release date: | 2023-02-08 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM structure of human voltage-gated sodium channel Na v 1.6. Proc.Natl.Acad.Sci.USA, 120, 2023
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4U20
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![BU of 4u20 by Molmil](/molmil-images/mine/4u20) | Crystal structure of the E. coli ribosome bound to flopristin. | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Noeske, J, Huang, J, Olivier, N.B, Giacobbe, R.A, Zambrowski, M, Cate, J.H.D. | Deposit date: | 2014-07-16 | Release date: | 2014-07-30 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Synergy of streptogramin antibiotics occurs independently of their effects on translation. Antimicrob.Agents Chemother., 58, 2014
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4U27
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![BU of 4u27 by Molmil](/molmil-images/mine/4u27) | Crystal structure of the E. coli ribosome bound to flopristin and linopristin. | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | Authors: | Noeske, J, Huang, J, Olivier, N.B, Giacobbe, R.A, Zambrowski, M, Cate, J.H.D. | Deposit date: | 2014-07-16 | Release date: | 2014-07-30 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Synergy of streptogramin antibiotics occurs independently of their effects on translation. Antimicrob.Agents Chemother., 58, 2014
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5DWD
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![BU of 5dwd by Molmil](/molmil-images/mine/5dwd) | Crystal structure of esterase PE8 | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, Esterase, GLYCEROL | Authors: | Li, J, Huang, J. | Deposit date: | 2015-09-22 | Release date: | 2016-10-26 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Structure of esterase PE8 To Be Published
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3KVO
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![BU of 3kvo by Molmil](/molmil-images/mine/3kvo) | Crystal structure of the catalytic domain of human Hydroxysteroid dehydrogenase like 2 (HSDL2) | Descriptor: | Hydroxysteroid dehydrogenase-like protein 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Ugochukwu, E, Bhatia, C, Huang, J, Pilka, E, Muniz, J.R.C, Pike, A.C.W, Krojer, T, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Bountra, C, Verdin, E.M, Oppermann, U, Kavanagh, K.L, Structural Genomics Consortium (SGC) | Deposit date: | 2009-11-30 | Release date: | 2010-03-09 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Crystal structure of the catalytic domain of human Hydroxysteroid dehydrogenase like 2 (HSDL2) To be Published
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1DT0
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![BU of 1dt0 by Molmil](/molmil-images/mine/1dt0) | CLONING, SEQUENCE, AND CRYSTALLOGRAPHIC STRUCTURE OF RECOMBINANT IRON SUPEROXIDE DISMUTASE FROM PSEUDOMONAS OVALIS | Descriptor: | FE (III) ION, SUPEROXIDE DISMUTASE | Authors: | Bond, C.J, Huang, J, Hajduk, R, Flick, K, Heath, P, Stoddard, B.L. | Deposit date: | 2000-01-10 | Release date: | 2000-12-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Cloning, sequence and crystallographic structure of recombinant iron superoxide dismutase from Pseudomonas ovalis. Acta Crystallogr.,Sect.D, 56, 2000
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1EMS
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![BU of 1ems by Molmil](/molmil-images/mine/1ems) | CRYSTAL STRUCTURE OF THE C. ELEGANS NITFHIT PROTEIN | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ETHYL MERCURY ION, NIT-FRAGILE HISTIDINE TRIAD FUSION PROTEIN, ... | Authors: | Pace, H.C, Hodawadekar, S.C, Draganescu, A, Huang, J, Bieganowski, P, Pekarsky, Y, Croce, C.M, Brenner, C. | Deposit date: | 2000-03-17 | Release date: | 2000-07-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers. Curr.Biol., 10, 2000
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4CC6
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![BU of 4cc6 by Molmil](/molmil-images/mine/4cc6) | Fragment-Based Discovery of 6 Azaindazoles As Inhibitors of Bacterial DNA Ligase | Descriptor: | 2-{[2-(1H-pyrazolo[3,4-c]pyridin-3-yl)-6-(trifluoromethyl)pyridin-4-yl]amino}ethanol, DNA LIGASE, SULFATE ION | Authors: | Howard, S, Amin, N, Benowitz, A.B, Chiarparin, E, Cui, H, Deng, X, Heightman, T.D, Holmes, D.J, Hopkins, A, Huang, J, Jin, Q, Kreatsoulas, C, Martin, A.C.L, Massey, F, McCloskey, L, Mortenson, P.N, Pathuri, P, Tisi, D, Williams, P.A. | Deposit date: | 2013-10-18 | Release date: | 2014-06-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Fragment-Based Discovery of 6-Azaindazoles as Inhibitors of Bacterial DNA Ligase. Acs Med.Chem.Lett., 4, 2013
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4CC5
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![BU of 4cc5 by Molmil](/molmil-images/mine/4cc5) | Fragment-Based Discovery of 6 Azaindazoles As Inhibitors of Bacterial DNA Ligase | Descriptor: | 2-chloranyl-6-(1H-1,2,4-triazol-3-yl)pyrazine, DNA LIGASE, SULFATE ION | Authors: | Howard, S, Amin, N, Benowitz, A.B, Chiarparin, E, Cui, H, Deng, X, Heightman, T.D, Holmes, D.J, Hopkins, A, Huang, J, Jin, Q, Kreatsoulas, C, Martin, A.C.L, Massey, F, McCloskey, L, Mortenson, P.N, Pathuri, P, Tisi, D, Williams, P.A. | Deposit date: | 2013-10-18 | Release date: | 2014-06-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Fragment-Based Discovery of 6-Azaindazoles as Inhibitors of Bacterial DNA Ligase. Acs Med.Chem.Lett., 4, 2013
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4E9A
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![BU of 4e9a by Molmil](/molmil-images/mine/4e9a) | Structure of Peptide Deformylase form Helicobacter Pylori in complex with inhibitor | Descriptor: | 2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, COBALT (II) ION, ... | Authors: | Cui, K, Zhu, L, Lu, W, Huang, J. | Deposit date: | 2012-03-20 | Release date: | 2013-04-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.662 Å) | Cite: | Identification of Novel Peptide Deformylase Inhibitors from Natural Products To be Published
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4E9B
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![BU of 4e9b by Molmil](/molmil-images/mine/4e9b) | Structure of Peptide Deformylase form Helicobacter Pylori in complex with actinonin | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACTINONIN, COBALT (II) ION, ... | Authors: | Cui, K, Zhu, L, Lu, W, Huang, J. | Deposit date: | 2012-03-20 | Release date: | 2013-04-24 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Identification of Novel Peptide Deformylase Inhibitors from Natural Products To be Published
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4R7L
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![BU of 4r7l by Molmil](/molmil-images/mine/4r7l) | Structure of Human Leukotriene A4 Hydrolase in complex with inhibitor H1 | Descriptor: | ACETATE ION, GLYCEROL, IMIDAZOLE, ... | Authors: | Ouyang, P, Cui, K, Lu, W, Huang, J. | Deposit date: | 2014-08-27 | Release date: | 2015-11-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Human Leukotriene A4 Hydrolase in complex with SAHA To be Published
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4RSY
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![BU of 4rsy by Molmil](/molmil-images/mine/4rsy) | Crystal structures of the Human leukotriene A4 Hydrolase complex with a potential inhibitor H7 | Descriptor: | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, ACETIC ACID, IMIDAZOLE, ... | Authors: | Ouyang, P, Lu, W, Cui, K, Huang, J. | Deposit date: | 2014-11-12 | Release date: | 2015-12-02 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Structure of Human Leukotriene A4 Hydrolase in complex with inhibitor H1 To be Published
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4RVB
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![BU of 4rvb by Molmil](/molmil-images/mine/4rvb) | Crystal Structure Analysis of the Human Leukotriene A4 Hydrolase | Descriptor: | ACETATE ION, ACETIC ACID, GLYCEROL, ... | Authors: | Ouyang, P, Lu, W, Cui, K, Huang, J. | Deposit date: | 2014-11-25 | Release date: | 2015-12-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Crystal Structure Analysis of the Human Leukotriene A4 Hydrolase To be Published
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6LK0
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![BU of 6lk0 by Molmil](/molmil-images/mine/6lk0) | Crystal structure of human wild type TRIP13 | Descriptor: | Pachytene checkpoint protein 2 homolog | Authors: | Wang, Y, Huang, J, Li, B, Xue, H, Tricot, G, Hu, L, Xu, Z, Sun, X, Chang, S, Gao, L, Tao, Y, Xu, H, Xie, Y, Xiao, W, Yu, D, Kong, Y, Chen, G, Sun, X, Lian, F, Zhang, N, Wu, X, Mao, Z, Zhan, F, Zhu, W, Shi, J. | Deposit date: | 2019-12-17 | Release date: | 2020-01-22 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A Small-Molecule Inhibitor Targeting TRIP13 Suppresses Multiple Myeloma Progression. Cancer Res., 80, 2020
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3J1T
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![BU of 3j1t by Molmil](/molmil-images/mine/3j1t) | High affinity dynein microtubule binding domain - tubulin complex | Descriptor: | Cytoplasmic dynein 1 heavy chain 1, seryl t-RNA synthetase chimera, Tubulin alpha-1B chain, ... | Authors: | Redwine, W.B, Hernandez-Lopez, R, Zou, S, Huang, J, Reck-Peterson, S.L, Leschziner, A.E. | Deposit date: | 2012-06-25 | Release date: | 2012-09-26 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (9.7 Å) | Cite: | Structural basis for microtubule binding and release by dynein. Science, 337, 2012
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3J1U
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![BU of 3j1u by Molmil](/molmil-images/mine/3j1u) | Low affinity dynein microtubule binding domain - tubulin complex | Descriptor: | Cytoplasmic dynein 1 heavy chain 1, seryl t-RNA synthetase chimera, Tubulin alpha-1B chain, ... | Authors: | Redwine, W.B, Hernandez-Lopez, R, Zou, S, Huang, J, Reck-Peterson, S.L, Leschziner, A.E. | Deposit date: | 2012-06-25 | Release date: | 2012-09-26 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (9.7 Å) | Cite: | Structural basis for microtubule binding and release by dynein. Science, 337, 2012
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8KD5
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![BU of 8kd5 by Molmil](/molmil-images/mine/8kd5) | Rpd3S in complex with nucleosome with H3K36MLA modification and 187bp DNA, class2 | Descriptor: | 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... | Authors: | Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Chang, X, Chao, W.C.H, He, J. | Deposit date: | 2023-08-09 | Release date: | 2023-09-13 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
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8KD6
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![BU of 8kd6 by Molmil](/molmil-images/mine/8kd6) | Rpd3S in complex with nucleosome with H3K36MLA modification and 187bp DNA, class3 | Descriptor: | 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... | Authors: | Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. | Deposit date: | 2023-08-09 | Release date: | 2023-09-13 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
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8KD3
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![BU of 8kd3 by Molmil](/molmil-images/mine/8kd3) | Rpd3S in complex with nucleosome with H3K36MLA modification, H3K9Q mutation and 187bp DNA | Descriptor: | 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... | Authors: | Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. | Deposit date: | 2023-08-09 | Release date: | 2023-09-13 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
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8KD4
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![BU of 8kd4 by Molmil](/molmil-images/mine/8kd4) | Rpd3S in complex with nucleosome with H3K36MLA modification and 187bp DNA, class1 | Descriptor: | 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... | Authors: | Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. | Deposit date: | 2023-08-09 | Release date: | 2023-09-13 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
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8KC7
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![BU of 8kc7 by Molmil](/molmil-images/mine/8kc7) | Rpd3S histone deacetylase complex | Descriptor: | Chromatin modification-related protein EAF3, Histone deacetylase RPD3, Transcriptional regulatory protein RCO1, ... | Authors: | Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. | Deposit date: | 2023-08-06 | Release date: | 2023-09-13 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
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8KD2
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![BU of 8kd2 by Molmil](/molmil-images/mine/8kd2) | Rpd3S in complex with 187bp nucleosome | Descriptor: | 187bp DNA, Chromatin modification-related protein EAF3, Histone H2A, ... | Authors: | Dong, S, Li, H, Wang, M, Rasheed, N, Zou, B, Gao, X, Guan, J, Li, W, Zhang, J, Wang, C, Zhou, N, Shi, X, Li, M, Zhou, M, Huang, J, Li, H, Zhang, Y, Wong, K.H, Zhang, X, Chao, W.C.H, He, J. | Deposit date: | 2023-08-09 | Release date: | 2023-09-13 | Last modified: | 2023-10-11 | Method: | ELECTRON MICROSCOPY (3.02 Å) | Cite: | Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res., 33, 2023
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