4JOD
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4JOB
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7VGG
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![BU of 7vgg by Molmil](/molmil-images/mine/7vgg) | Cryo-EM structure of Ultraviolet-B activated UVR8 in complex with COP1 | Descriptor: | E3 ubiquitin-protein ligase COP1, Ultraviolet-B receptor UVR8 | Authors: | Wang, Y.D, Wang, L.X, Guan, Z.Y, Yin, P. | Deposit date: | 2021-09-16 | Release date: | 2022-05-04 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insight into UV-B-activated UVR8 bound to COP1. Sci Adv, 8, 2022
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5XQX
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5XWV
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2I3I
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![BU of 2i3i by Molmil](/molmil-images/mine/2i3i) | Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic | Descriptor: | (3R,6R,9AR)-2,2-DIMETHYL-6-[(N-METHYL-L-ALANYL)AMINO]-N-(3-METHYL-1-PHENYL-1H-PYRAZOL-5-YL)-5-OXO-2,3,5,6,9,9A-HEXAHYDRO[1,3]THIAZOLO[3,2-A]AZEPINE-3-CARBOXAMIDE, 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | Authors: | Fairbrother, W.J, Franklin, M.C. | Deposit date: | 2006-08-18 | Release date: | 2006-09-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. Acs Chem.Biol., 1, 2006
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5YAT
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7EJV
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![BU of 7ejv by Molmil](/molmil-images/mine/7ejv) | The co-crystal structure of DYRK2 with YK-2-69 | Descriptor: | Dual specificity tyrosine-phosphorylation-regulated kinase 2, [6-[[4-[2-(dimethylamino)-1,3-benzothiazol-6-yl]-5-fluoranyl-pyrimidin-2-yl]amino]pyridin-3-yl]-(4-ethylpiperazin-1-yl)methanone | Authors: | Li, Z, Xiao, Y, Yuan, K, Kuang, W, Xiuquan, Y, Yang, P. | Deposit date: | 2021-04-02 | Release date: | 2022-04-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer. Nat Commun, 13, 2022
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5XYN
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![BU of 5xyn by Molmil](/molmil-images/mine/5xyn) | The crystal structure of Csm2-Psy3-Shu1-Shu2 complex from budding yeast | Descriptor: | Chromosome segregation in meiosis protein 2, Platinum sensitivity protein 3, Suppressor of HU sensitivity involved in recombination protein 1, ... | Authors: | Zhang, S, Zhang, T, Ding, J. | Deposit date: | 2017-07-09 | Release date: | 2017-11-08 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural basis for the functional role of the Shu complex in homologous recombination. Nucleic Acids Res., 45, 2017
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5YDR
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![BU of 5ydr by Molmil](/molmil-images/mine/5ydr) | Structure of DNMT1 RFTS domain in complex with ubiquitin | Descriptor: | DNA (cytosine-5)-methyltransferase 1, PHOSPHATE ION, Polyubiquitin-B, ... | Authors: | Qian, C. | Deposit date: | 2017-09-14 | Release date: | 2018-02-21 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.003 Å) | Cite: | Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation. Nucleic Acids Res., 46, 2018
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3SKH
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2I3H
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![BU of 2i3h by Molmil](/molmil-images/mine/2i3h) | Structure of an ML-IAP/XIAP chimera bound to a 4-mer peptide (AVPW) | Descriptor: | 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, AVPW peptide, ... | Authors: | Fairbrother, W.J, Franklin, M.C. | Deposit date: | 2006-08-18 | Release date: | 2006-09-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. Acs Chem.Biol., 1, 2006
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3SKA
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2NRW
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2NRZ
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2NRR
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2NRX
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![BU of 2nrx by Molmil](/molmil-images/mine/2nrx) | Crystal structure of the C-terminal half of UvrC, in the presence of sulfate molecules | Descriptor: | GLYCEROL, SULFATE ION, UvrABC system protein C | Authors: | Karakas, E, Truglio, J.J, Kisker, C. | Deposit date: | 2006-11-02 | Release date: | 2007-02-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure of the C-terminal half of UvrC reveals an RNase H endonuclease domain with an Argonaute-like catalytic triad. Embo J., 26, 2007
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2P2H
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![BU of 2p2h by Molmil](/molmil-images/mine/2p2h) | Crystal structure of the VEGFR2 kinase domain in complex with a pyridinyl-triazine inhibitor | Descriptor: | 4-(2-anilinopyridin-3-yl)-N-(3,4,5-trimethoxyphenyl)-1,3,5-triazin-2-amine, Vascular endothelial growth factor receptor 2 | Authors: | Whittington, D.A, Kim, J.L, Long, A.M, Rose, P, Gu, Y, Zhao, H. | Deposit date: | 2007-03-07 | Release date: | 2007-03-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Evolution of a Highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor J.Med.Chem., 50, 2007
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2P4I
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2P2I
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![BU of 2p2i by Molmil](/molmil-images/mine/2p2i) | Crystal structure of the VEGFR2 kinase domain in complex with a nicotinamide inhibitor | Descriptor: | N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide, Vascular endothelial growth factor receptor 2 | Authors: | Whittington, D.A, Kim, J.L, Long, A.M, Rose, P, Gu, Y, Zhao, H. | Deposit date: | 2007-03-07 | Release date: | 2007-03-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Evolution of a Highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor J.Med.Chem., 50, 2007
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2NRT
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2OO8
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![BU of 2oo8 by Molmil](/molmil-images/mine/2oo8) | Synthesis, Structural Analysis, and SAR Studies of Triazine Derivatives as Potent, Selective Tie-2 Inhibitors | Descriptor: | Angiopoietin-1 receptor, N-{3-[3-(DIMETHYLAMINO)PROPYL]-5-(TRIFLUOROMETHYL)PHENYL}-4-METHYL-3-[(3-PYRIMIDIN-4-YLPYRIDIN-2-YL)AMINO]BENZAMIDE | Authors: | Bellon, S.F, Kim, J. | Deposit date: | 2007-01-25 | Release date: | 2007-03-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors. Bioorg.Med.Chem.Lett., 17, 2007
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3S94
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![BU of 3s94 by Molmil](/molmil-images/mine/3s94) | Crystal structure of LRP6-E1E2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Low-density lipoprotein receptor-related protein 6 | Authors: | Cheng, Z, Xu, W. | Deposit date: | 2011-05-31 | Release date: | 2011-11-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structures of the extracellular domain of LRP6 and its complex with DKK1. Nat.Struct.Mol.Biol., 18, 2011
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2OPH
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![BU of 2oph by Molmil](/molmil-images/mine/2oph) | Human dipeptidyl peptidase IV in complex with an alpha amino acid inhibitor | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Scapin, G, Weber, A.E, Duffy, J.L. | Deposit date: | 2007-01-29 | Release date: | 2007-05-08 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | 4-Aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV. Bioorg.Med.Chem.Lett., 17, 2007
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3S8Z
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![BU of 3s8z by Molmil](/molmil-images/mine/3s8z) | Crystal structure of LRP6-E3E4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Low-density lipoprotein receptor-related protein 6 | Authors: | Cheng, Z, Xu, W. | Deposit date: | 2011-05-31 | Release date: | 2011-10-26 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structures of the extracellular domain of LRP6 and its complex with DKK1. Nat.Struct.Mol.Biol., 18, 2011
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